Gene Symbol: smyd1b
Description: SET and MYND domain containing 1b
Alias: sth, symd1, SET and MYND domain-containing protein 1, fla, flatline, histone methyltransferase SmyD1
Species: zebrafish

Top Publications

  1. Bernick E, Zhang P, Du S. Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos. BMC Cell Biol. 2010;11:70 pubmed publisher
    ..Collectively, these studies indicate that the expression levels of Unc-45b must be precisely regulated to ensure normal myofibril organization. Loss or overexpression of Unc-45b leads to defective myofibril organization. ..
  2. Tan X, Rotllant J, Li H, De Deyne P, DeDeyne P, Du S. SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos. Proc Natl Acad Sci U S A. 2006;103:2713-8 pubmed
    ..Here we report that SmyD1a and SmyD1b, generated by alternative splicing of SmyD1 gene, are histone methyltransferases that play a key role in skeletal ..
  3. Du S, Rotllant J, Tan X. Muscle-specific expression of the smyd1 gene is controlled by its 5.3-kb promoter and 5'-flanking sequence in zebrafish embryos. Dev Dyn. 2006;235:3306-15 pubmed
    ..Together, these data indicate that smyd1 is specifically expressed in most, if not all, striated muscles, and the muscle specificity is controlled by the 5.3-kb promoter and flanking sequences. ..
  4. Just S, Meder B, Berger I, Etard C, Trano N, Patzel E, et al. The myosin-interacting protein SMYD1 is essential for sarcomere organization. J Cell Sci. 2011;124:3127-36 pubmed publisher
    ..However, the molecules that mediate these processes are largely unknown. Here, we isolated the zebrafish mutant flatline (fla), which shows disturbed sarcomere assembly exclusively in heart and fast-twitch skeletal muscle...
  5. Li H, Xu J, Bian Y, Rotllant P, Shen T, Chu W, et al. Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers. PLoS ONE. 2011;6:e28524 pubmed publisher
    b>Smyd1b is a member of the Smyd family that plays a key role in sarcomere assembly during myofibrillogenesis...
  6. Xu J, Gao J, Li J, Xue L, Clark K, Ekker S, et al. Functional analysis of slow myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles. J Genet Genomics. 2012;39:69-80 pubmed publisher
    ..Together, these studies indicate that myosin thick filaments are required for M-line organization and M-line localization of myomesin-3. In contrast, myomesin-3 is dispensable for sarcomere organization in slow muscles...
  7. Li H, Zhong Y, Wang Z, Gao J, Xu J, Chu W, et al. Smyd1b is required for skeletal and cardiac muscle function in zebrafish. Mol Biol Cell. 2013;24:3511-21 pubmed publisher
    b>Smyd1b is a member of the Smyd family that is specifically expressed in skeletal and cardiac muscles. Smyd1b plays a key role in thick filament assembly during myofibrillogenesis in skeletal muscles of zebrafish embryos...
  8. Prill K, Windsor Reid P, Wohlgemuth S, Pilgrim D. Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly. PLoS ONE. 2015;10:e0142528 pubmed publisher
    ..The cognate gene for the mutant was shown to be smyd1b and the still heart mutation results in an early nonsense codon...
  9. Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden F, et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development. 1996;123:293-302 pubmed
    ..The mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis. ..

More Information


  1. Wang Q, Tan X, Jiao S, You F, Zhang P. Analyzing cold tolerance mechanism in transgenic zebrafish (Danio rerio). PLoS ONE. 2014;9:e102492 pubmed publisher
    ..These results are clues to understanding the mechanisms underlying temperature acclimation in fish. ..
  2. He Q, Liu K, Tian Z, Du S. The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization. PLoS ONE. 2015;10:e0142573 pubmed publisher
  3. Etard C, Armant O, Roostalu U, Gourain V, Ferg M, Strähle U. Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome Biol. 2015;16:267 pubmed publisher
    Mutations in myosin chaperones Unc45b and Hsp90aa1.1 as well as in the Unc45b-binding protein Smyd1b impair formation of myofibrils in skeletal muscle and lead to the accumulation of misfolded myosin...
  4. Rudeck S, Etard C, Khan M, Rottbauer W, Rudolf R, Strahle U, et al. A compact unc45b-promoter drives muscle-specific expression in zebrafish and mouse. Genesis. 2016;54:431-8 pubmed publisher
    ..fragment is able to rescue the embryonically lethal heart and skeletal muscle defects in smyd1b-deficient flatline mutant zebrafish...
  5. Hinits Y, Pan L, Walker C, Dowd J, Moens C, Hughes S. Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Dev Biol. 2012;369:199-210 pubmed publisher
    ..hand2 but results in a dramatic loss of expression of sarcomeric genes and myocardial markers such as bmp4, nppa, smyd1b and late nkx2.5 mRNA...
  6. Gao J, Li J, Li B, Yagil E, Zhang J, Du S. Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles. PLoS ONE. 2014;9:e86808 pubmed publisher
    ..Bioinformatic analysis revealed that zebrafish genome contains two highly related smyd1 genes, smyd1a and smyd1b. Although Smyd1b function is well characterized in skeletal and cardiac muscles, the function of Smyd1a is, ..