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Genomes and Genes
| smoSummaryGene Symbol: smo Description: smoothened homolog (Drosophila) Alias: CHUNP6862, smoh, wu:fb70b01, wu:fc39h03, slow muscle omitted, smoothened homolog, smu Species: zebrafish Top Publications
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Publications
Intra-endodermal interactions are required for pancreatic beta cell inductionWon Suk Chung
Department of Biochemistry and Biophysics, and the Diabetes Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Dev Cell 14:582-93. 2008....
Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryoS Roy
MRC Intercellular Signalling Group, Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, S10 2TN, Sheffield, United Kingdom
Curr Biol 11:1358-63. 2001..Our results suggest that Hh proteins influence pancreas specification via inductive interactions from the axial midline rather than through their localized expression in the endodermal cells themselves...
Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layersCecilia Lanny Winata
Department of Biological Sciences, National University of Singapore, Singapore
Dev Biol 331:222-36. 2009..Furthermore, time-specific Hh inhibition by cyclopamine revealed different requirements of Hh signaling in the formation and organization of all three tissue layers of swimbladder...- The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identityM J Barresi
Biology Department, Wesleyan University, Middletown, CT 06459, USA
Development 127:2189-99. 2000..We report here that mutations in the zebrafish slow-muscle-omitted (smu) gene disrupt many developmental processes involving Hedgehog signaling... - Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without ciliaPeng Huang
Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 136:3089-98. 2009..As in mouse, zebrafish cilia are required to mediate the activities of Hh, Ptc, Smo and PKA... - Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesisClarissa A Henry
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 USA
Dev Cell 7:917-23. 2004..Thus, the medial to lateral migration of slow muscle fibers through the somite creates a morphogenetic signal that patterns fast muscle fiber elongation in its wake... - Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedMiao Hsueh Chen
Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 23:1910-28. 2009..In contrast, fly Smo is unable to translocate to the primary cilium and activate the mammalian Hh pathway... - The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafishIan G Woods
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 3:e66. 2005..Our positional cloning and functional studies demonstrate that You is a novel extracellular component of the Hedgehog pathway in vertebrates... - Vertebrate Smoothened functions at the primary ciliumKevin C Corbit
Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
Nature 437:1018-21. 2005..Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium... - The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesisAndrew M Glazer
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Dev Biol 337:148-56. 2010..Our results indicate that a critical and broadly conserved function for Iguana is in ciliogenesis and that this function has come to be required for Hedgehog signaling in vertebrates... - Zebrafish smoothened functions in ventral neural tube specification and axon tract formationZ M Varga
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
Development 128:3497-509. 2001..To examine the role of Hedgehog signaling in zebrafish, we have characterized slow muscle omitted (smu) mutants. We show that smu encodes a zebrafish ortholog of Smoothened that transduces Hedgehog signals... - Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skullNaoyuki Wada
Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
Development 132:3977-88. 2005.... - The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signalingPia Aanstad
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
Curr Biol 19:1034-9. 2009..The seven-transmembrane domain (7TM) protein Smoothened (Smo) is essential for the activation of all levels of Hh signaling... - Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellumKaren A McFarland
Department of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232, USA
Dev Biol 318:162-71. 2008..Specifically, we propose that Hedgehog limits the range of Wnt signaling, which is necessary for olig2(+) neuron development... - Wnt signaling is required for early development of zebrafish swimbladderAo Yin
Department of Biological Sciences, National University of Singapore, Singapore, Singapore
PLoS ONE 6:e18431. 2011..To investigate the potential conservation of signaling events in early development of the lung and swimbladder, we wish to address the question whether Wnt signaling plays a role in swimbladder development... - Zebrafish Sox7 and Sox18 function together to control arterial-venous identityHelene Pendeville
GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
Dev Biol 317:405-16. 2008..The striking similarities between the phenotype of Sox7/Sox18 morphants and Gridlock mutants strongly suggest that Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression... - Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independentJohn K Mich
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Biol 328:342-54. 2009..PGC migration in the Drosophila embryo and that downstream signaling proteins such as Patched (Ptc) and Smoothened (Smo) are required for PGC localization to somatic gonadal precursors... - Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesisChristopher W Wilson
Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Nature 459:98-102. 2009..Our results delineate a new pathway for central pair apparatus assembly, identify common regulators of Hh signalling and motile ciliogenesis, and provide insights into the evolution of the Hh cascade... - Hedgehog signalling is required for cloacal development in the zebrafish embryoCaroline A Parkin
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, U K
Int J Dev Biol 53:45-57. 2009..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes... - Zebrafish cardiac development requires a conserved secondary heart fieldDanyal Hami
Department of Pediatrics, Duke University, Durham, NC 27710, USA
Development 138:2389-98. 2011.... - Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinaseMelanie Philipp
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Mol Biol Cell 19:5478-89. 2008..Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development... - Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreasSeung Woo Park
Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Gastroenterology 134:2080-90. 2008..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos... - Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potentialNatalie A Thomas
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Development 135:3789-99. 2008..Thus, Hh signaling plays an essential early role in defining the optimal number of cardiomyocytes, making it an attractive target for manipulation of multipotent progenitor cells... - Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate developmentTomoya Kotani
Laboratory of Reproductive and Developmental Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060 0810, Japan
J Biol Chem 285:5106-16. 2010.... - Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterningKatherine L Hammond
MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
Gene Expr Patterns 9:391-6. 2009..Hip-mediated inhibition of Hh signalling may therefore be important in restricting the effects of Hh to posterior regions of the developing inner ear... - Sonic hedgehog is a polarized signal for motor neuron regeneration in adult zebrafishMichell M Reimer
Centre for Neuroregeneration, School of Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
J Neurosci 29:15073-82. 2009.... - Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expressionNicholas A Sanek
Department of Zoology and Anatomy, University of Wisconsin, Madison, WI 53706, USA
Development 136:3791-800. 2009..These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE... - Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fateCharles Williams
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Dev Biol 341:196-204. 2010..endothelial progenitor cells) during arterial-venous specification utilizing zebrafish mutations in Smoothened (Smo), a G protein-coupled receptor essential for Hh signaling... - Muscle contractions guide rohon-beard peripheral sensory axonsJeremiah D Paulus
Departments of Zoology and Anatomy and Cell and Molecular Biology Training Program, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 29:13190-201. 2009..This work suggests that the mechanical forces generated by muscle contractions are necessary for proper sensory axon pathfinding in vivo... - miR-145 directs intestinal maturation in zebrafishLei Zeng
Biochemistry and Molecular Biology, and Smooth Muscle Research Group, University of Calgary, Calgary, AB, Canada T2N 4N1
Proc Natl Acad Sci U S A 106:17793-8. 2009..miR-145 therefore plays a critical role in promoting the maturation of both layers of the gut during development through regulation of gata6... - Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafishHyejeong Rosemary Kim
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
BMC Biol 8:65. 2010.... - Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesisMichael J F Barresi
Biological Sciences, Smith College, Northampton, Massachusetts 01063, USA
Dev Dyn 239:2603-18. 2010..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS... - Cdkn1c drives muscle differentiation through a positive feedback loop with MyodDaniel P S Osborn
King s College London, Randall Division for Cell and Molecular Biophysics, London, UK
Dev Biol 350:464-75. 2011..Cdkn1c co-operates with Myod to drive differentiation of several early zebrafish muscle fibre types. Myod in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation... - Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancerNelson S Yee
Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Dis Model Mech 4:240-54. 2011..Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg(2+)-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis... - Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafishBensheng Ju
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Mol Cancer 8:40. 2009..These results suggest that co-activation of the hedgehog and AKT pathways promote tumorigenesis, and that the binary transgenic approach is a useful tool for studying interaction of oncogenes and oncogenic pathways in zebrafish... - Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopmentZhiyuan Ke
Department of Biological Sciences, National University of Singapore, Singapore
Mol Cell Neurosci 37:388-401. 2008..Gli2b acts in cell proliferation and plays an early role in the hindbrain within a regulatory cascade involving Notch and Ngn1, as well as a role as specific activator in rhombomere 4... - Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafishYavor Hadzhiev
Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
BMC Dev Biol 7:75. 2007..However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown... - A screen for genetic defects of the zebrafish earAndria Schibler
Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Mech Dev 124:592-604. 2007..As it proved to be the case in past screening efforts of this type, these mutant lines represent an asset in the studies of molecular mechanisms that regulate vertebrate ear development... - The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identityK B Rohr
Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
Neuron 29:341-51. 2001..Thus, the Nodal pathway regulates ventral forebrain patterning through both Hedgehog signaling-dependent and -independent mechanisms... - gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafishSarah E Cheesman
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Gene Expr Patterns 5:107-12. 2004..These data suggest gsh1 may play a role in patterning cell types generated in these domains... - Hedgehog signaling is required for commitment but not initial induction of slow muscle precursorsEstelle Hirsinger
Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
Dev Biol 275:143-57. 2004.... - Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryosH Teraoka
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
J Neurobiol 60:275-88. 2004..Our results show that the pathways involved in induction of hindbrain serotonergic neurons are likely to be conserved in all vertebrates and help establish the zebrafish as a model system to study this important neuronal class... - Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neuronsJosette M Ungos
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420 USA
Development 130:5351-62. 2003..These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors... - Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plateAlexandra Tallafuss
Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Munich, Germany
Dev Dyn 227:524-35. 2003..1/no-isthmus and smoothened/slow muscle omitted mutants, where identities adjacent to the six3 cluster are altered; however, in these mutants, the .. - Multiple roles for Hedgehog signaling in zebrafish pituitary developmentJennifer L Sbrogna
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
Dev Biol 254:19-35. 2003..These defects, ranging from a complete loss of the adenohypophysis (smu/smo and yot/gli2 mutants) to more subtle patterning defects (dtr/gli1 mutants), may correlate to human Hh signaling .. - Cyclops-independent floor plate differentiation in zebrafish embryosStephanie Albert
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
Dev Dyn 226:59-66. 2003..This finding suggests that the correct temporal development of the MFP is required for the distinction of LFP and MFP cells in wild-type embryos... - Making the connection: retinal axon guidance in the zebrafishJames Culverwell
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
Semin Cell Dev Biol 13:497-506. 2002..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain... - Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1Nicolas B David
Groupe Danio, Institut National de la Santé et de la Recherche Médicale U368, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris, France
Proc Natl Acad Sci U S A 99:16297-302. 2002..We conclude that both the formation and the innervation of this system depend on the SDF1-CXCR4 system, which has also been implicated in several migration events in humans, including metastasis formation and lymphocyte homing... - olig2 is required for zebrafish primary motor neuron and oligodendrocyte developmentHae Chul Park
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Dev Biol 248:356-68. 2002..One possibility consistent with these data is that Hedgehog signaling, partly by inducing olig2 expression, specifies neural precursor cells that have potential for primary motor neuron or oligodendrocyte fate... - Sonic hedgehog is required early in pancreatic islet developmentPhilip J diIorio
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Dev Biol 244:75-84. 2002..The early action of Shh may be part of a more general process allowing neuroendocrine cells to originate in nonneuroectodermally derived tissues... - pitx3 defines an equivalence domain for lens and anterior pituitary placodeSunit Dutta
Department of Developmental Biology, University Freiburg, Germany
Development 132:1579-90. 2005..During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types... - The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturationIchiro Masai
Masai Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, Hirosawa, Saitama, Japan
Development 132:1539-53. 2005..This dual requirement of Hh signalling in RGC differentiation implies that the regulation of a neurogenic wave is more complex in the zebrafish retina than in the Drosophila eye... - Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expressionHiroki Teraoka
Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
Aquat Toxicol 78:103-13. 2006..TCDD may impair jaw growth through other pathway(s) in addition to Hh signaling... - Scube2 mediates Hedgehog signalling in the zebrafish embryoGeorgina E Hollway
Muscle Development Laboratory, The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
Dev Biol 294:104-18. 2006..Epistatic and molecular analyses position Scube2 function upstream of Smoothened (Smoh), the signalling component of the HH receptor complex, suggesting that Scube2 may act during HH signal transduction .. - Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of SmoothenedHaruki Ochi
Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
Dev Biol 297:127-40. 2006..These data support a model in which Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened... - Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesisMasanari Takamiya
Institute of Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Cologne, Germany
Dev Dyn 235:978-97. 2006..Such differences seem to be created in part by regional effector signalling; the effects of high Hh-signalling on medial neurogenesis can be reversed in accordance to medial Tri/Stbm level, in a polarity independent manner... - Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoterHaiyan Wan
Department of Biological Sciences, National University of Singapore, Singapore
Exp Cell Res 312:1526-39. 2006..By transferring the elaA:gfp transgene into slow muscle omitted mutant that is deficient in receiving Hedgehog signals, we further showed that Hedgehog signaling is .. - Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial developmentJohann K Eberhart
Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
Development 133:1069-77. 2006..We observe that in mutants for the Hh co-receptor smoothened (smo) the condensation of this specific subset of crest cells fails, and expression of several genes is lost in the .. - Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiationXuesong Feng
Department of Biology, Wesleyan University, Middletown, CT 06459, USA
Dev Biol 300:736-46. 2006..We propose that Hedgehog signaling acts at multiple times on different lineages, through different downstream pathways, to promote myogenic differentiation... - The genetics of hearing and balance in zebrafishTeresa Nicolson
Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Annu Rev Genet 39:9-22. 2005..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish... - sox4b is a key player of pancreatic alpha cell differentiation in zebrafishAnastasia Mavropoulos
Laboratoire de Biologie Moléculaire et de Génie Génétique, Center of Biomedical Integrative Genoproteomics CBIG, Universite de Liege, Institut de Chimie, Batiment B6, 4000 Liege Sart Tilman, Belgium
Dev Biol 285:211-23. 2005..Taken together, these data demonstrate that, in zebrafish, sox4b is expressed transiently during endocrine cell differentiation and plays a crucial role in the generation of alpha endocrine cells... - Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retinaJeremy N Kay
Department of Physiology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Development 132:2573-85. 2005.... - Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activityMasaya Take-Uchi
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
Development 130:955-68. 2003..Taking all these results together, we present a model of the partitioning of the optic vesicle along its proximo-distal axis... - FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9Virginie Esain
INSERM, U784, Laboratoire de Génétique Moléculaire du Développement, 46 rue d Ulm, 75230 Paris Cedex 05, France
Development 137:33-42. 2010..Overall, for the first time in vivo, our results reveal a mechanism of FGF in the control of neural cell diversity... - Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicleKatherine L Hammond
Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Western Bank, Sheffield S10 2TN, UK
Development 130:1403-17. 2003..We demonstrate that two strong Hedgehog pathway mutants, chameleon (con(tf18b)) and slow muscle omitted (smu(b641)) exhibit a striking partial mirror image duplication of anterior otic structures, concomitant .. - olig1 Expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signalingMichael Schebesta
Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
Dev Dyn 238:887-98. 2009..Lastly, knockdown of Olig1 in an Olig2-sensitized background did result in defects in CNS myelination, indicating a functional overlap between Olig1 and Olig2 proteins... - Converse conformational control of smoothened activity by structurally related small moleculesHongbo Yang
College of Life Sciences, Peking University, Beijing 100871, China
J Biol Chem 284:20876-84. 2009The seven-pass transmembrane protein Smoothened (Smo) is an essential component of the Hedgehog (Hh) signaling pathway that is critically involved in normal animal development as well as pathological malignancies... - Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathwayAlyson M Wilbanks
Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Science and Policy, Duke University Medical Center, Durham, NC 27710, USA
Science 306:2264-7. 2004..These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development...
Research Grants
- Bacterial regulation of GI tract cell proliferationSarah Cheeseman; Fiscal Year: 2007..The details of this interaction are relevant to human health, as the activities of the Gl microbiota are implicated in several hyperproliferative diseases of the Gl tract, including irritable bowel syndrome and colorectal cancer. ..
- Genetic Hierarchies and Cellular Behaviors during Zebrafish PalatogenesisJohann Eberhart; Fiscal Year: 2007..Additionally, two genes I propose to analyze, pitx2 and ephrin-B1, are known to be human craniofacial disease genes. Therefore, my analyses of these genes will provide direct insight into the cause of human disease. ..
- Developmental Compartments of the Zebrafish NeurocraniumJohann Eberhart; Fiscal Year: 2005..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
- Axon guidance in the developing zebrafish brainMICHAEL BARRESI; Fiscal Year: 2004..This research will lead to a better understanding of events critical to establishing neural connections across the midline in the vertebrate brain. ..
- Genetic and molecular dissection of hair-cell functionTeresa Nicolson; Fiscal Year: 2009..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..