smo

Summary

Gene Symbol: smo
Description: smoothened homolog (Drosophila)
Alias: CHUNP6862, smoh, wu:fb70b01, wu:fc39h03, slow muscle omitted, smoothened homolog, smu
Species: zebrafish

Top Publications

  1. pmc Intra-endodermal interactions are required for pancreatic beta cell induction
    Won Suk Chung
    Department of Biochemistry and Biophysics, and the Diabetes Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 14:582-93. 2008
  2. pmc The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish
    Ian G Woods
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 3:e66. 2005
  3. ncbi Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis
    Clarissa A Henry
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 USA
    Dev Cell 7:917-23. 2004
  4. doi Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers
    Cecilia Lanny Winata
    Department of Biological Sciences, National University of Singapore, Singapore
    Dev Biol 331:222-36. 2009
  5. pmc The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
    Pia Aanstad
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
    Curr Biol 19:1034-9. 2009
  6. ncbi Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
    S Roy
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, S10 2TN, Sheffield, United Kingdom
    Curr Biol 11:1358-63. 2001
  7. ncbi Zebrafish smoothened functions in ventral neural tube specification and axon tract formation
    Z M Varga
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Development 128:3497-509. 2001
  8. ncbi Vertebrate Smoothened functions at the primary cilium
    Kevin C Corbit
    Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
    Nature 437:1018-21. 2005
  9. ncbi The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
    M J Barresi
    Biology Department, Wesleyan University, Middletown, CT 06459, USA
    Development 127:2189-99. 2000
  10. pmc The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis
    Andrew M Glazer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Dev Biol 337:148-56. 2010

Scientific Experts

  • Hiroki Teraoka
  • John K Mich
  • Peng Huang
  • Bensheng Ju
  • Tomoya Kotani
  • Nelson S Yee
  • Yavor Hadzhiev
  • MICHAEL J BARRESI
  • Masanari Takamiya
  • Johann K Eberhart
  • Jeremy N Kay
  • Z M Varga
  • Masaya Take uchi
  • TERESA A NICOLSON
  • SARAH E CHEESEMAN
  • Ichiro Masai
  • S W Wilson
  • Pia Aanstad
  • Vladimir Korzh
  • Zhiyuan Gong
  • Katherine L Hammond
  • Melanie Philipp
  • Christopher W Wilson
  • Miao Hsueh Chen
  • Pao Tien Chuang
  • Marc G Caron
  • Didier Y R Stainier
  • Rolf O Karlstrom
  • Kevin C Corbit
  • Ami Ketley
  • Monte Westerfield
  • Tom Stückemann
  • Cornelia Stacher Hörndli
  • Kuan Shen Wong
  • Daniel P S Osborn
  • Tama Evron
  • Ao Yin
  • Danyal Hami
  • Virginie Esain
  • Charles Williams
  • Andrew M Glazer
  • Hyejeong Rosemary Kim
  • Alison R Meloni
  • Wei Chen
  • Philip W Ingham
  • Jennifer L Sbrogna
  • Cecilia Lanny Winata
  • Caroline A Parkin
  • Michell M Reimer
  • Lei Zeng
  • Jeremiah D Paulus
  • Nicholas A Sanek
  • Michael Schebesta
  • Hongbo Yang
  • Rhodora Gacayan
  • Svitlana Korzh
  • Seung Woo Park
  • Won Suk Chung
  • Helene Pendeville
  • Zhiyuan Ke
  • Karen A McFarland
  • Natalie A Thomas
  • Shuo Lin
  • Margaret L Kirby
  • Andria Schibler
  • Jeremy F Reiter
  • Joseph A Martial
  • Patrick Motte
  • Bernard Peers
  • Gregory B Fralish
  • Haruki Ochi
  • Georgina E Hollway
  • Tanya T Whitfield
  • Xuesong Feng
  • Haiyan Wan
  • Naoyuki Wada
  • Bruce Appel
  • Ian G Woods
  • Stephen H Devoto
  • Sunit Dutta
  • Anastasia Mavropoulos
  • Sarah E Cheesman
  • Alyson M Wilbanks
  • Estelle Hirsinger
  • Clarissa A Henry
  • Josette M Ungos
  • Stephanie Albert
  • Masaya Take-Uchi
  • Alexandra Tallafuss
  • Nicolas B David

Detail Information

Publications75

  1. pmc Intra-endodermal interactions are required for pancreatic beta cell induction
    Won Suk Chung
    Department of Biochemistry and Biophysics, and the Diabetes Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 14:582-93. 2008
    ....
  2. pmc The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish
    Ian G Woods
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 3:e66. 2005
    ..Our positional cloning and functional studies demonstrate that You is a novel extracellular component of the Hedgehog pathway in vertebrates...
  3. ncbi Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis
    Clarissa A Henry
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 USA
    Dev Cell 7:917-23. 2004
    ..Thus, the medial to lateral migration of slow muscle fibers through the somite creates a morphogenetic signal that patterns fast muscle fiber elongation in its wake...
  4. doi Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers
    Cecilia Lanny Winata
    Department of Biological Sciences, National University of Singapore, Singapore
    Dev Biol 331:222-36. 2009
    ..Furthermore, time-specific Hh inhibition by cyclopamine revealed different requirements of Hh signaling in the formation and organization of all three tissue layers of swimbladder...
  5. pmc The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
    Pia Aanstad
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
    Curr Biol 19:1034-9. 2009
    ..The seven-transmembrane domain (7TM) protein Smoothened (Smo) is essential for the activation of all levels of Hh signaling...
  6. ncbi Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
    S Roy
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, S10 2TN, Sheffield, United Kingdom
    Curr Biol 11:1358-63. 2001
    ..Our results suggest that Hh proteins influence pancreas specification via inductive interactions from the axial midline rather than through their localized expression in the endodermal cells themselves...
  7. ncbi Zebrafish smoothened functions in ventral neural tube specification and axon tract formation
    Z M Varga
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Development 128:3497-509. 2001
    ..To examine the role of Hedgehog signaling in zebrafish, we have characterized slow muscle omitted (smu) mutants. We show that smu encodes a zebrafish ortholog of Smoothened that transduces Hedgehog signals...
  8. ncbi Vertebrate Smoothened functions at the primary cilium
    Kevin C Corbit
    Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
    Nature 437:1018-21. 2005
    ..Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium...
  9. ncbi The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
    M J Barresi
    Biology Department, Wesleyan University, Middletown, CT 06459, USA
    Development 127:2189-99. 2000
    ..We report here that mutations in the zebrafish slow-muscle-omitted (smu) gene disrupt many developmental processes involving Hedgehog signaling...
  10. pmc The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis
    Andrew M Glazer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Dev Biol 337:148-56. 2010
    ..Our results indicate that a critical and broadly conserved function for Iguana is in ciliogenesis and that this function has come to be required for Hedgehog signaling in vertebrates...
  11. pmc The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development
    Ami Ketley
    Centre for Genetics and Genomics, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 8:e65170. 2013
    ..Our results indicate that fine coordination of smoothened activity by the miR-30 family allows the correct specification and differentiation of distinct muscle cell types during zebrafish embryonic development...
  12. doi Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling
    Tom Stückemann
    Institute of Molecular Biology, University of Innsbruck, Technikerstrasse 25, Innsbruck, Austria
    Development 139:2711-20. 2012
    ....
  13. pmc Sonic hedgehog is indirectly required for intraretinal axon pathfinding by regulating chemokine expression in the optic stalk
    Cornelia Stacher Hörndli
    Program in Neuroscience, Department of Neurobiology and Anatomy, University of Utah Medical Center, 20 North 1900 East, Salt Lake City, UT 84132, USA
    Development 139:2604-13. 2012
    ..Together, our results support a model in which Shh acts in RGC axon pathfinding indirectly by regulating axon guidance cues at the optic disc through patterning of the optic stalk...
  14. pmc Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    Miao Hsueh Chen
    Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 23:1910-28. 2009
    ..In contrast, fly Smo is unable to translocate to the primary cilium and activate the mammalian Hh pathway...
  15. doi Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish
    Kuan Shen Wong
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, USA
    Dev Biol 361:377-91. 2012
    ..Simultaneous knockdown of the two zebrafish sonic hedgehog homologs, shh and twhh or Hh co-receptor smoothened (smo) resulted in similar defects in endocardial morphogenesis...
  16. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
    ..As in mouse, zebrafish cilia are required to mediate the activities of Hh, Ptc, Smo and PKA...
  17. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ....
  18. doi Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish
    John K Mich
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:5113-9. 2011
    ..We also provide evidence that RA pathway activation can modulate Gli function in a Hh ligand-independent manner. These findings support a model in which Hh and RA signaling cooperate to promote PMN cell fates in zebrafish...
  19. pmc Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling
    Tama Evron
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:27676-86. 2011
    The G protein-coupled receptor (GPCR)-like molecule Smoothened (Smo) undergoes dynamic intracellular trafficking modulated by the microtubule associated kinase GRK2 and recruitment of β-arrestin...
  20. pmc Muscle contractions guide rohon-beard peripheral sensory axons
    Jeremiah D Paulus
    Departments of Zoology and Anatomy and Cell and Molecular Biology Training Program, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 29:13190-201. 2009
    ..This work suggests that the mechanical forces generated by muscle contractions are necessary for proper sensory axon pathfinding in vivo...
  21. pmc Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer
    Nelson S Yee
    Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dis Model Mech 4:240-54. 2011
    ..Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg(2+)-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis...
  22. pmc Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent
    John K Mich
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 328:342-54. 2009
    ..PGC migration in the Drosophila embryo and that downstream signaling proteins such as Patched (Ptc) and Smoothened (Smo) are required for PGC localization to somatic gonadal precursors...
  23. pmc Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis
    Christopher W Wilson
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Nature 459:98-102. 2009
    ..Our results delineate a new pathway for central pair apparatus assembly, identify common regulators of Hh signalling and motile ciliogenesis, and provide insights into the evolution of the Hh cascade...
  24. doi Hedgehog signalling is required for cloacal development in the zebrafish embryo
    Caroline A Parkin
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, U K
    Int J Dev Biol 53:45-57. 2009
    ..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes...
  25. doi Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
    Natalie A Thomas
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 135:3789-99. 2008
    ..Thus, Hh signaling plays an essential early role in defining the optimal number of cardiomyocytes, making it an attractive target for manipulation of multipotent progenitor cells...
  26. pmc Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase
    Melanie Philipp
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 19:5478-89. 2008
    ..Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development...
  27. pmc Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    Seung Woo Park
    Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 134:2080-90. 2008
    ..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos...
  28. pmc Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum
    Karen A McFarland
    Department of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232, USA
    Dev Biol 318:162-71. 2008
    ..Specifically, we propose that Hedgehog limits the range of Wnt signaling, which is necessary for olig2(+) neuron development...
  29. pmc Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis
    Michael J F Barresi
    Biological Sciences, Smith College, Northampton, Massachusetts 01063, USA
    Dev Dyn 239:2603-18. 2010
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS...
  30. ncbi Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning
    Katherine L Hammond
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Gene Expr Patterns 9:391-6. 2009
    ..Hip-mediated inhibition of Hh signalling may therefore be important in restricting the effects of Hh to posterior regions of the developing inner ear...
  31. pmc Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression
    Nicholas A Sanek
    Department of Zoology and Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 136:3791-800. 2009
    ..These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE...
  32. pmc Zebrafish cardiac development requires a conserved secondary heart field
    Danyal Hami
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    Development 138:2389-98. 2011
    ....
  33. pmc miR-145 directs intestinal maturation in zebrafish
    Lei Zeng
    Biochemistry and Molecular Biology, and Smooth Muscle Research Group, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 106:17793-8. 2009
    ..miR-145 therefore plays a critical role in promoting the maturation of both layers of the gut during development through regulation of gata6...
  34. pmc Sonic hedgehog is a polarized signal for motor neuron regeneration in adult zebrafish
    Michell M Reimer
    Centre for Neuroregeneration, School of Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 29:15073-82. 2009
    ....
  35. pmc Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development
    Tomoya Kotani
    Laboratory of Reproductive and Developmental Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060 0810, Japan
    J Biol Chem 285:5106-16. 2010
    ....
  36. pmc Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate
    Charles Williams
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Dev Biol 341:196-204. 2010
    ..endothelial progenitor cells) during arterial-venous specification utilizing zebrafish mutations in Smoothened (Smo), a G protein-coupled receptor essential for Hh signaling...
  37. pmc Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
    Hyejeong Rosemary Kim
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
    BMC Biol 8:65. 2010
    ....
  38. pmc Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish
    Bensheng Ju
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Mol Cancer 8:40. 2009
    ..These results suggest that co-activation of the hedgehog and AKT pathways promote tumorigenesis, and that the binary transgenic approach is a useful tool for studying interaction of oncogenes and oncogenic pathways in zebrafish...
  39. pmc Wnt signaling is required for early development of zebrafish swimbladder
    Ao Yin
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    PLoS ONE 6:e18431. 2011
    ..To investigate the potential conservation of signaling events in early development of the lung and swimbladder, we wish to address the question whether Wnt signaling plays a role in swimbladder development...
  40. doi Zebrafish Sox7 and Sox18 function together to control arterial-venous identity
    Helene Pendeville
    GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
    Dev Biol 317:405-16. 2008
    ..The striking similarities between the phenotype of Sox7/Sox18 morphants and Gridlock mutants strongly suggest that Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression...
  41. ncbi pitx3 defines an equivalence domain for lens and anterior pituitary placode
    Sunit Dutta
    Department of Developmental Biology, University Freiburg, Germany
    Development 132:1579-90. 2005
    ..During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types...
  42. ncbi gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish
    Sarah E Cheesman
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Gene Expr Patterns 5:107-12. 2004
    ..These data suggest gsh1 may play a role in patterning cell types generated in these domains...
  43. ncbi Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors
    Estelle Hirsinger
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Dev Biol 275:143-57. 2004
    ....
  44. pmc Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos
    H Teraoka
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurobiol 60:275-88. 2004
    ..Our results show that the pathways involved in induction of hindbrain serotonergic neurons are likely to be conserved in all vertebrates and help establish the zebrafish as a model system to study this important neuronal class...
  45. ncbi Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons
    Josette M Ungos
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420 USA
    Development 130:5351-62. 2003
    ..These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors...
  46. ncbi Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plate
    Alexandra Tallafuss
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Munich, Germany
    Dev Dyn 227:524-35. 2003
    ..1/no-isthmus and smoothened/slow muscle omitted mutants, where identities adjacent to the six3 cluster are altered; however, in these mutants, the ..
  47. ncbi Multiple roles for Hedgehog signaling in zebrafish pituitary development
    Jennifer L Sbrogna
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Dev Biol 254:19-35. 2003
    ..These defects, ranging from a complete loss of the adenohypophysis (smu/smo and yot/gli2 mutants) to more subtle patterning defects (dtr/gli1 mutants), may correlate to human Hh signaling ..
  48. pmc Cdkn1c drives muscle differentiation through a positive feedback loop with Myod
    Daniel P S Osborn
    King s College London, Randall Division for Cell and Molecular Biophysics, London, UK
    Dev Biol 350:464-75. 2011
    ..Cdkn1c co-operates with Myod to drive differentiation of several early zebrafish muscle fibre types. Myod in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation...
  49. ncbi Cyclops-independent floor plate differentiation in zebrafish embryos
    Stephanie Albert
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
    Dev Dyn 226:59-66. 2003
    ..This finding suggests that the correct temporal development of the MFP is required for the distinction of LFP and MFP cells in wild-type embryos...
  50. ncbi Making the connection: retinal axon guidance in the zebrafish
    James Culverwell
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Semin Cell Dev Biol 13:497-506. 2002
    ..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain...
  51. pmc Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1
    Nicolas B David
    Groupe Danio, Institut National de la Santé et de la Recherche Médicale U368, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris, France
    Proc Natl Acad Sci U S A 99:16297-302. 2002
    ..We conclude that both the formation and the innervation of this system depend on the SDF1-CXCR4 system, which has also been implicated in several migration events in humans, including metastasis formation and lymphocyte homing...
  52. ncbi olig2 is required for zebrafish primary motor neuron and oligodendrocyte development
    Hae Chul Park
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Dev Biol 248:356-68. 2002
    ..One possibility consistent with these data is that Hedgehog signaling, partly by inducing olig2 expression, specifies neural precursor cells that have potential for primary motor neuron or oligodendrocyte fate...
  53. ncbi Sonic hedgehog is required early in pancreatic islet development
    Philip J diIorio
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 244:75-84. 2002
    ..The early action of Shh may be part of a more general process allowing neuroendocrine cells to originate in nonneuroectodermally derived tissues...
  54. ncbi The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation
    Ichiro Masai
    Masai Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, Hirosawa, Saitama, Japan
    Development 132:1539-53. 2005
    ..This dual requirement of Hh signalling in RGC differentiation implies that the regulation of a neurogenic wave is more complex in the zebrafish retina than in the Drosophila eye...
  55. ncbi sox4b is a key player of pancreatic alpha cell differentiation in zebrafish
    Anastasia Mavropoulos
    Laboratoire de Biologie Moléculaire et de Génie Génétique, Center of Biomedical Integrative Genoproteomics CBIG, Universite de Liege, Institut de Chimie, Batiment B6, 4000 Liege Sart Tilman, Belgium
    Dev Biol 285:211-23. 2005
    ..Taken together, these data demonstrate that, in zebrafish, sox4b is expressed transiently during endocrine cell differentiation and plays a crucial role in the generation of alpha endocrine cells...
  56. ncbi The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity
    K B Rohr
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 29:341-51. 2001
    ..Thus, the Nodal pathway regulates ventral forebrain patterning through both Hedgehog signaling-dependent and -independent mechanisms...
  57. ncbi Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened
    Haruki Ochi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Dev Biol 297:127-40. 2006
    ..These data support a model in which Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened...
  58. ncbi Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation
    Xuesong Feng
    Department of Biology, Wesleyan University, Middletown, CT 06459, USA
    Dev Biol 300:736-46. 2006
    ..We propose that Hedgehog signaling acts at multiple times on different lineages, through different downstream pathways, to promote myogenic differentiation...
  59. ncbi A screen for genetic defects of the zebrafish ear
    Andria Schibler
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Mech Dev 124:592-604. 2007
    ..As it proved to be the case in past screening efforts of this type, these mutant lines represent an asset in the studies of molecular mechanisms that regulate vertebrate ear development...
  60. ncbi Scube2 mediates Hedgehog signalling in the zebrafish embryo
    Georgina E Hollway
    Muscle Development Laboratory, The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
    Dev Biol 294:104-18. 2006
    ..Epistatic and molecular analyses position Scube2 function upstream of Smoothened (Smoh), the signalling component of the HH receptor complex, suggesting that Scube2 may act during HH signal transduction ..
  61. ncbi Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression
    Hiroki Teraoka
    Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    Aquat Toxicol 78:103-13. 2006
    ..TCDD may impair jaw growth through other pathway(s) in addition to Hh signaling...
  62. pmc Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
    Yavor Hadzhiev
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
    BMC Dev Biol 7:75. 2007
    ..However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown...
  63. ncbi Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis
    Masanari Takamiya
    Institute of Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Cologne, Germany
    Dev Dyn 235:978-97. 2006
    ..Such differences seem to be created in part by regional effector signalling; the effects of high Hh-signalling on medial neurogenesis can be reversed in accordance to medial Tri/Stbm level, in a polarity independent manner...
  64. ncbi Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter
    Haiyan Wan
    Department of Biological Sciences, National University of Singapore, Singapore
    Exp Cell Res 312:1526-39. 2006
    ..By transferring the elaA:gfp transgene into slow muscle omitted mutant that is deficient in receiving Hedgehog signals, we further showed that Hedgehog signaling is ..
  65. ncbi Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment
    Zhiyuan Ke
    Department of Biological Sciences, National University of Singapore, Singapore
    Mol Cell Neurosci 37:388-401. 2008
    ..Gli2b acts in cell proliferation and plays an early role in the hindbrain within a regulatory cascade involving Notch and Ngn1, as well as a role as specific activator in rhombomere 4...
  66. ncbi Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development
    Johann K Eberhart
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Development 133:1069-77. 2006
    ..We observe that in mutants for the Hh co-receptor smoothened (smo) the condensation of this specific subset of crest cells fails, and expression of several genes is lost in the ..
  67. ncbi The genetics of hearing and balance in zebrafish
    Teresa Nicolson
    Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Annu Rev Genet 39:9-22. 2005
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish...
  68. doi olig1 Expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling
    Michael Schebesta
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    Dev Dyn 238:887-98. 2009
    ..Lastly, knockdown of Olig1 in an Olig2-sensitized background did result in defects in CNS myelination, indicating a functional overlap between Olig1 and Olig2 proteins...
  69. ncbi Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle
    Katherine L Hammond
    Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Western Bank, Sheffield S10 2TN, UK
    Development 130:1403-17. 2003
    ..We demonstrate that two strong Hedgehog pathway mutants, chameleon (con(tf18b)) and slow muscle omitted (smu(b641)) exhibit a striking partial mirror image duplication of anterior otic structures, concomitant ..
  70. ncbi Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity
    Masaya Take-Uchi
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Development 130:955-68. 2003
    ..Taking all these results together, we present a model of the partitioning of the optic vesicle along its proximo-distal axis...
  71. pmc Converse conformational control of smoothened activity by structurally related small molecules
    Hongbo Yang
    College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 284:20876-84. 2009
    The seven-pass transmembrane protein Smoothened (Smo) is an essential component of the Hedgehog (Hh) signaling pathway that is critically involved in normal animal development as well as pathological malignancies...
  72. pmc FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9
    Virginie Esain
    INSERM, U784, Laboratoire de Génétique Moléculaire du Développement, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 137:33-42. 2010
    ..Overall, for the first time in vivo, our results reveal a mechanism of FGF in the control of neural cell diversity...
  73. ncbi Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
    Alyson M Wilbanks
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Science and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Science 306:2264-7. 2004
    ..These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development...
  74. ncbi Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina
    Jeremy N Kay
    Department of Physiology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Development 132:2573-85. 2005
    ....

Research Grants11

  1. Bacterial regulation of GI tract cell proliferation
    Sarah Cheeseman; Fiscal Year: 2007
    ..The details of this interaction are relevant to human health, as the activities of the Gl microbiota are implicated in several hyperproliferative diseases of the Gl tract, including irritable bowel syndrome and colorectal cancer. ..
  2. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2007
    ..Additionally, two genes I propose to analyze, pitx2 and ephrin-B1, are known to be human craniofacial disease genes. Therefore, my analyses of these genes will provide direct insight into the cause of human disease. ..
  3. Developmental Compartments of the Zebrafish Neurocranium
    Johann Eberhart; Fiscal Year: 2005
    ..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
  4. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
    ..This research will lead to a better understanding of events critical to establishing neural connections across the midline in the vertebrate brain. ..
  5. Genetic and molecular dissection of hair-cell function
    Teresa Nicolson; Fiscal Year: 2009
    ..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..