Gene Symbol: smc3
Description: structural maintenance of chromosomes 3
Alias: cspg6, im:7142991, wu:fb22e01, wu:fc30d07, structural maintenance of chromosomes protein 3, chondroitin sulfate proteoglycan 6 (bamacan)
Ghiselli G. SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer. 2006;5:52 pubmed
The structural maintenance of chromosome 3 (SMC3) protein is a constituent of a number of nuclear multimeric protein complexes that are involved in DNA recombination and repair in addition to chromosomal segregation...
Horsfield J, Anagnostou S, Hu J, Cho K, Geisler R, Lieschke G, et al
. Cohesin-dependent regulation of Runx genes. Development. 2007;134:2639-49 pubmed
..Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development...
Ruuskanen J, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan Y, et al
. Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol Biol Evol. 2004;21:14-28 pubmed
Mönnich M, Banks S, Eccles M, Dickinson E, Horsfield J. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene Expr Patterns. 2009;9:586-94 pubmed publisher
..Cohesin genes smc1a, rad21, pds5b and smc3 were expressed in the forebrain ventricular zone, the tectum, the mid-hindbrain boundary, the fourth ventricle, ..
Xu B, Sowa N, Cardenas M, Gerton J. L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Hum Mol Genet. 2015;24:1540-55 pubmed publisher
..show that phosphorylation of RPS6 as well as 4E-binding protein 1 (4EBP1) was reduced in nipbla/b, rad21 and smc3-morphant embryos, a pattern indicating reduced translation...
Lorent K, Gong W, Koo K, Waisbourd Zinman O, Karjoo S, Zhao X, et al
. Identification of a plant isoflavonoid that causes biliary atresia. Sci Transl Med. 2015;7:286ra67 pubmed publisher
..Together, these findings provide direct evidence that BA could be initiated by perinatal exposure to an environmental toxin. ..
Kuo M, Postlethwait J, Lee W, Lou S, Chan W, Chung B. Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. Biochem J. 2005;389:19-26 pubmed
..Thus we have characterized the phylogenetic relationships, expression patterns and chromosomal locations of these Ftz-F1 genes, and have demonstrated their identities as NR5A genes in relation to the orthologous genes in other species. ..