Gene Symbol: slit1a
Description: slit homolog 1a (Drosophila)
Alias: slit homolog 1 protein
Species: zebrafish
Products:     slit1a

Top Publications

  1. Xiao T, Staub W, Robles E, Gosse N, Cole G, Baier H. Assembly of lamina-specific neuronal connections by slit bound to type IV collagen. Cell. 2011;146:164-76 pubmed publisher
    ..We propose that Slit1 signaling, perhaps in the form of a superficial-to-deep gradient, presents laminar positional cues to ingrowing retinal axons. ..
  2. Barresi M, Hutson L, Chien C, Karlstrom R. Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development. 2005;132:3643-56 pubmed
    ..form in regions devoid of the guidance molecules slit2 and slit3, although a subset of these glial cells express slit1a. We show that Hh signaling is required for commissure formation, glial bridge formation, and the restricted ..
  3. Wyatt C, Ebert A, Reimer M, Rasband K, Hardy M, Chien C, et al. Analysis of the astray/robo2 zebrafish mutant reveals that degenerating tracts do not provide strong guidance cues for regenerating optic axons. J Neurosci. 2010;30:13838-49 pubmed publisher
  4. Campbell D, Stringham S, Timm A, Xiao T, Law M, Baier H, et al. Slit1a inhibits retinal ganglion cell arborization and synaptogenesis via Robo2-dependent and -independent pathways. Neuron. 2007;55:231-45 pubmed
    ..ast (robo2) mutant and slit1a morphant arbors had more branch tips and greater arbor area and complexity compared to wild-type and concomitantly ..
  5. Zhang C, Gao J, Zhang H, Sun L, Peng G. Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts. J Neurosci. 2012;32:12589-602 pubmed publisher
    ..These findings demonstrate how Robo2-Slit and Dcc-Netrin coordinate the axonal projection choices of the developing neurons in the vertebrate forebrain. ..
  6. Förster D, Arnold Ammer I, Laurell E, Barker A, Fernandes A, Finger Baier K, et al. Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools. Sci Rep. 2017;7:5230 pubmed publisher
    ..Taken together, our study offers new tools for functional studies of specific neural circuits in zebrafish. ..
  7. Chalasani S, Sabol A, Xu H, Gyda M, Rasband K, Granato M, et al. Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. J Neurosci. 2007;27:973-80 pubmed
    ..These results demonstrate that endogenous levels of SDF1 antagonize the repellent effects of slit/robo signaling in vivo and that this antagonism is important during axonal pathfinding. ..
  8. Bergeron S, Tyurina O, Miller E, Bagas A, Karlstrom R. Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development. 2011;138:75-85 pubmed publisher
    ..This study reveals a role for Boc in ventral CNS cells that receive high levels of Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis. ..
  9. Hofmeister W, Devine C, Rothnagel J, Key B. Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon. Mech Dev. 2012;129:109-24 pubmed publisher
    ..In the absence of this platform of glia, commissural axons fail to cross the rostral midline of the forebrain. ..

More Information


  1. Campbell D, Okamoto H. Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization. J Cell Biol. 2013;203:657-72 pubmed publisher
    ..Genetic analysis showed that Caspase-3, Caspase-9, and p38 MAPK interacted with Slit1a-Robo2 signaling, suggesting that localized activation of caspases lie downstream of a ligand receptor system, ..
  2. Zecca A, Dyballa S, Voltes A, Bradley R, Pujades C. The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain. J Neurosci. 2015;35:7475-86 pubmed publisher
  3. Isaacman Beck J, Schneider V, Franzini Armstrong C, Granato M. The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration. Neuron. 2015;88:691-703 pubmed publisher
    ..probing inappropriate trajectories to ensure target-selective regeneration, possibly through the axonal repellant slit1a. Our results demonstrate that selective ECM components match subpopulations of regenerating axons with their ..
  4. Hutson L, Jurynec M, Yeo S, Okamoto H, Chien C. Two divergent slit1 genes in zebrafish. Dev Dyn. 2003;228:358-69 pubmed
    ..Here, we describe the cloning of full-length cDNAs for two zebrafish slit orthologs, slit1a and slit1b. Both predicted proteins contain the conserved motifs that characterize other vertebrate Slits...
  5. Devine C, Key B. Robo-Slit interactions regulate longitudinal axon pathfinding in the embryonic vertebrate brain. Dev Biol. 2008;313:371-83 pubmed
    ..Robo2 acted initially to split the TPOC into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon...
  6. Miyasaka N, Sato Y, Yeo S, Hutson L, Chien C, Okamoto H, et al. Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system. Development. 2005;132:1283-93 pubmed
    ..These data provide functional evidence for Robo2/Slit signaling in the establishment of olfactory neural circuitry in zebrafish. ..
  7. Takeuchi M, Yamaguchi S, Yonemura S, Kakiguchi K, Sato Y, Higashiyama T, et al. Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. PLoS Genet. 2015;11:e1005587 pubmed publisher
    ..These results collectively suggest that type IV collagen controls GC axon formation by regulating the integrity of the BM, which provides axons with the correct path to their targets. ..
  8. Kastenhuber E, Kern U, Bonkowsky J, Chien C, Driever W, Schweitzer J. Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. J Neurosci. 2009;29:8914-26 pubmed publisher
    ..Simultaneous integrations of repulsive and attractive long-range cues from the midline act in a concerted manner to define lateral positions of DA longitudinal axon tracts. ..
  9. Pan Y, Choy M, Prober D, Schier A. Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development. 2012;139:591-600 pubmed publisher
    ..In the absence of Robo2, Isl1SS afferents acquire many of the characteristics of Trpa1b afferents. These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system. ..
  10. Yeo S, Miyashita T, Fricke C, Little M, Yamada T, Kuwada J, et al. Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish. Mech Dev. 2004;121:315-24 pubmed
  11. Schweitzer J, Löhr H, Bonkowsky J, Hübscher K, Driever W. Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development. 2013;140:93-106 pubmed publisher
    ..Therefore, Sim1a and Arnt2 contribute to control of lateral positioning of longitudinal hypothalamic-spinal axons by negative regulation of robo3a.1 expression, which in turn attenuates the repulsive activity of Robo2. ..
  12. Paulus J, Halloran M. Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects. Dev Dyn. 2006;235:213-24 pubmed
    ..In contrast to CNS axons, most peripheral axons appear normal in bal mutants. Our results, thus, reveal important and diverse functions for laminin-alpha1 in guiding developing axons in vivo. ..
  13. Samuel A, Rubinstein A, Azar T, Ben Moshe Livne Z, Kim S, Inbal A. Six3 regulates optic nerve development via multiple mechanisms. Sci Rep. 2016;6:20267 pubmed publisher
    ..Hence, the new zebrafish model for Six3 loss of function furthers our understanding of the mechanisms governing optic nerve development and Six3-mediated eye and forebrain malformations. ..