Gene Symbol: slc6a9
Description: solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Alias: glyt1, sodium- and chloride-dependent glycine transporter 1, Sho, shocked, solute carrier family 6 member 9
Higashijima S, Mandel G, Fetcho J. Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol. 2004;480:1-18 pubmed
..The differences in the distribution of excitatory and inhibitory neurons in spinal cord versus hindbrain may be tied to differences in their patterns of development and functional organization. ..
Cui W, Low S, Hirata H, Saint Amant L, Geisler R, Hume R, et al
. The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS. J Neurosci. 2005;25:6610-20 pubmed
b>shocked (sho) is a zebrafish mutation that causes motor deficits attributable to CNS defects during the first2dof development...
Roy N, Arpie B, Lugo J, Linney E, Levin E, Cerutti D. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicol Teratol. 2012;34:587-91 pubmed publisher
..Taken together, these data show that a short embryonic exposure to a neurotoxicant can alter development of neural synapses and lead to changes in adult behavior. ..
Kullander K. Genetics moving to neuronal networks. Trends Neurosci. 2005;28:239-47 pubmed
Mongeon R, Gleason M, Masino M, Fetcho J, Mandel G, Brehm P, et al
. Synaptic homeostasis in a zebrafish glial glycine transporter mutant. J Neurophysiol. 2008;100:1716-23 pubmed publisher
Truncated escape responses characteristic of the zebrafish shocked mutant result from a defective glial glycine transporter (GlyT1)...
Hirata H, Ogino K, Yamada K, Leacock S, Harvey R. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. J Neurosci. 2013;33:14638-44 pubmed publisher
..To our knowledge, this is the first identification of pathologically relevant substrates for an RNA helicase...
Seredick S, Van Ryswyk L, Hutchinson S, Eisen J. Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Dev. 2012;7:35 pubmed publisher
..This is, to our knowledge, the first report of transcription factors that act to distinguish CaP and MiP subtype identities. Our results also suggest that MiP motoneurons are more similar to V2 interneurons than are CaP motoneurons. ..
Kondrychyn I, Teh C, Sin M, Korzh V. Stretching morphogenesis of the roof plate and formation of the central canal. PLoS ONE. 2013;8:e56219 pubmed publisher
..The resistance of the roof plate cytoskeleton attenuates ventral displacement of the central canal in illustration of the novel mechanical role of the roof plate during development of the body axis. ..
Ganser L, Yan Q, James V, Kozol R, Topf M, Harvey R, et al
. Distinct phenotypes in zebrafish models of human startle disease. Neurobiol Dis. 2013;60:139-51 pubmed publisher
..Based on our findings, future studies that aim to model candidate startle disease genes in zebrafish should include measures of spasticity and synaptic development...