slc5a5

Summary

Gene Symbol: slc5a5
Description: solute carrier family 5 (sodium/iodide cotransporter), member 5
Alias: si:ch211-200a16.4, sodium/iodide cotransporter, NIS, solute carrier family 5 (sodium iodide symporter), member 5
Species: zebrafish

Top Publications

  1. Liu Y, Wang J, Fang X, Zhang H, Dai J. The thyroid-disrupting effects of long-term perfluorononanoate exposure on zebrafish (Danio rerio). Ecotoxicology. 2011;20:47-55 pubmed publisher
    ..Our results provide the first evidence for the thyroid-disrupting effects of long-term PFNA exposure in zebrafish. ..
  2. Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae. Aquat Toxicol. 2010;97:226-33 pubmed publisher
    ..The transcription of genes involved in the synthesis of TH proteins, sodium/iodide symporter (Slc5a5), and thyroglobulin (TG) and the transcription of marker genes associated with early thyroid development (Pax8 and ..
  3. Thienpont B, Tingaud Sequeira A, Prats E, Barata C, Babin P, Raldua D. Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis. Environ Sci Technol. 2011;45:7525-32 pubmed publisher
    ..relevance of T4-intrafollicular content was clearly higher than regulation at the transcriptional level of tg or slc5a5. Moreover, concentration-response analysis provided information about the thyroid disrupting potency and hazard of ..
  4. Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C, et al. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquat Toxicol. 2013;126:207-13 pubmed publisher
    ..with TDCPP also significantly increased transcription of genes involved in thyroid hormone synthesis (tsh?, slc5a5 and tg) and thyroid development (hhex, nkx2...
  5. Alt B, Reibe S, Feitosa N, Elsalini O, Wendl T, Rohr K. Analysis of origin and growth of the thyroid gland in zebrafish. Dev Dyn. 2006;235:1872-83 pubmed
    ..Mosaic analysis suggests that the first thyroid follicle differentiating at 55 hours postfertilization corresponds later to the most anterior follicle and that new follicles are added caudally. ..
  6. Yu L, Chen M, Liu Y, Gui W, Zhu G. Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole. Aquat Toxicol. 2013;138-139:35-42 pubmed publisher
    ..e., corticotrophin-releasing hormone (CRH), thyroid-stimulating hormone (TSH?), sodium/iodide symporter (NIS), transthyretin (TTR), uridine diphosphate glucuronosyltransferase (UGT1ab), thyronine deiodinase (Dio1 and Dio2), ..
  7. Liang X, Yu L, Gui W, Zhu G. Exposure to difenoconazole causes changes of thyroid hormone and gene expression levels in zebrafish larvae. Environ Toxicol Pharmacol. 2015;40:983-7 pubmed publisher
    ..HPT axis were significantly up-regulated, but the transcriptions of thyroglobulin (tg), sodium/iodide symporter (nis) and thyroid hormone receptors trβ were not changed...
  8. Han Z, Li Y, Zhang S, Song N, Xu H, Dang Y, et al. Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring. Aquat Toxicol. 2017;190:46-52 pubmed publisher
    ..These results suggest that exposure of parent zebrafish to BDE-209 can cause developmental toxicity in offspring and disruption of the thyroid endocrine system of offspring. ..
  9. Kwon B, Kho Y, Kim P, Ji K. Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole. Environ Toxicol Pharmacol. 2016;48:168-174 pubmed publisher
    ..The present study indicated that BPAF exposure alone alters transcription of genes associated with the thyroid endocrine system, and combination with SMX could increase the endocrine disrupting effect of BPAF. ..

More Information

Publications35

  1. Zheng X, Zhu Y, Liu C, Liu H, Giesy J, Hecker M, et al. Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis. Environ Sci Technol. 2012;46:12943-51 pubmed publisher
    ..hormone receptor (TSHR), thyroid hormone receptors (TRs, including TR? and TR?), sodium/iodide symporter (NIS), and transthyretin (TTR) while up-regulating expression of thyroglobulin (TG) and thyrotropin-releasing hormone (..
  2. Zhai W, Huang Z, Chen L, Feng C, Li B, Li T. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP). PLoS ONE. 2014;9:e92465 pubmed publisher
    ..1 and Pax8) and thyroid hormone synthesis (TSH?, NIS and TG)...
  3. Tang T, Yang Y, Chen Y, Tang W, Wang F, Diao X. Thyroid Disruption in Zebrafish Larvae by Short-Term Exposure to Bisphenol AF. Int J Environ Res Public Health. 2015;12:13069-84 pubmed publisher
    ..However, slc5a5 gene transcription was significantly down-regulated at 50 μg/L and 500 μg/L BPAF exposure...
  4. Chen Q, Yu L, Yang L, Zhou B. Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae. Aquat Toxicol. 2012;110-111:141-8 pubmed publisher
    ..Genes involved in thyroid development (Pax8 and Nkx2.1) and synthesis (sodium/iodide symporter, NIS, thyroglobulin, TG) were also transcriptionally up-regulated...
  5. Zhao X, Wang S, Li D, You H, Ren X. Effects of perchlorate on BDE-47-induced alteration thyroid hormone and gene expression of in the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Environ Toxicol Pharmacol. 2013;36:1176-85 pubmed publisher
    ..5 mg/L) significantly up-regulated the expression of genes involved in TH synthesis (NIS and Nkx2...
  6. Huang G, Tian X, Fang X, Ji F. Waterborne exposure to bisphenol F causes thyroid endocrine disruption in zebrafish larvae. Chemosphere. 2016;147:188-94 pubmed publisher
    ..BPF also significantly increased transcription of genes involved in thyroid hormone regulation (crh) and synthesis (nis and tg) as a compensatory mechanism for the decrease of T4 contents...
  7. Kim S, Jung J, Lee I, Jung D, Youn H, Choi K. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat Toxicol. 2015;160:188-96 pubmed publisher
    ..In the FRTL-5 cells, the expression of the nis and tpo genes was significantly up-regulated, suggesting that TPP stimulates thyroid hormone synthesis in the ..
  8. Liu C, Yu H, Zhang X. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 2013;93:2327-32 pubmed publisher
    ..Exposure to PTU increased mRNA expression of sodium iodide symporter (nis) and thyroglobulin (tg) involved in HPT axis, and MET treatment up-regulated all the mRNA expression tested ..
  9. Jia P, Ma Y, Lu C, Mirza Z, Zhang W, Jia Y, et al. The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP. PLoS ONE. 2016;11:e0155762 pubmed publisher
    ..1 and pax8) and thyroid synthesis (sodium/iodide symporter, nis, thyroglobulin, tg) were also measured. The transcripts of nkx2...
  10. Shi X, Liu C, Wu G, Zhou B. Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2009;77:1010-8 pubmed publisher
    ..e., corticotropin-releasing factor (CRF), thyroid-stimulating hormone (TSH), sodium/iodide symporter (NIS), thyroglobulin (TG), thyroid peroxidase (TPO), transthyretin (TTR), iodothyronine deiodinases (Dio1 and Dio2) and ..
  11. Usenko C, Hopkins D, Trumble S, Bruce E. Hydroxylated PBDEs induce developmental arrest in zebrafish. Toxicol Appl Pharmacol. 2012;262:43-51 pubmed publisher
    ..This study suggests that hydroxylated PBDEs disrupt development, and may induce oxidative stress and potentially disrupt the cholinergic system and thyroid hormone homeostasis. ..
  12. Cheng H, Yan W, Wu Q, Liu C, Gong X, Hung T, et al. Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity. Environ Pollut. 2017;230:981-988 pubmed publisher
    ..We regard these adverse effects as a parental transgenerational toxicity of MCLR. ..
  13. Liang X, Li J, Martyniuk C, Wang J, Mao Y, Lu H, et al. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos. Chemosphere. 2017;182:22-30 pubmed publisher
    ..Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. ..
  14. Tu W, Xu C, Jin Y, Lu B, Lin C, Wu Y, et al. Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence. Aquat Toxicol. 2016;175:39-46 pubmed publisher
    ..Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish. This study provides a rapid and cost-effective approach for identifying THDCs and the underlying mechanisms. ..
  15. Liang Y, Huang G, Ying G, Liu S, Jiang Y, Liu S. Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:101-7 pubmed publisher
    ..However, a strong induction of Nis mRNA by P4 and NGT was observed in zebrafish embryos-larvae...
  16. Opitz R, Maquet E, Zoenen M, Dadhich R, Costagliola S. TSH receptor function is required for normal thyroid differentiation in zebrafish. Mol Endocrinol. 2011;25:1579-99 pubmed publisher
    ..A comparison of our results with phenotypes observed in mouse models of defective TSHR and cAMP signaling highlights the value of zebrafish as a model to enhance the understanding of functional differentiation in the vertebrate thyroid. ..
  17. Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, et al. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17 pubmed publisher
    ..Therefore, our morphants recapitulate the RTHα and RTHβ key manifestations representing new models in which the functional consequences of human TR mutations can be rapidly and faithfully evaluated. ..
  18. Fetter E, Baldauf L, Da Fonte D, Ortmann J, Scholz S. Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos. Reprod Toxicol. 2015;57:10-20 pubmed publisher
    ..We propose the tg(tg:mCherry) bioassay as a sensitive tool in medium scale screening of goitrogens, given the minimal effort for sample preparation and analysis of gene expression. ..
  19. Porazzi P, Marelli F, Benato F, de Filippis T, Calebiro D, Argenton F, et al. Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish. Endocrinology. 2012;153:5645-58 pubmed publisher
    ..Thus, genetic alterations affecting the Notch pathway may confer susceptibility for thyroid dysgenesis. ..
  20. Zhang D, Zhou E, Yang Z. Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS ONE. 2017;12:e0176927 pubmed publisher
    ..The transcription of genes involved in thyroid development (pax8) and synthesis (sodium/iodide symporter, slc5a5) were also significantly increased in the 30 ?g/L of BPS treatment group...
  21. Wendl T, Adzic D, Schoenebeck J, Scholpp S, Brand M, Yelon D, et al. Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development. 2007;134:2871-9 pubmed
    ..FGF-soaked beads can restore thyroid development in han mutants, showing that FGFs act downstream of or in parallel to han. These data suggest that loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects. ..
  22. Jianjie C, Wenjuan X, Jinling C, Jie S, Ruhui J, Meiyan L. Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio). Aquat Toxicol. 2016;171:48-58 pubmed publisher
    ..hormone (CRH), thyroid-stimulating hormone (TSH), thyroglobulin (TG), sodium iodide symporter (NIS), iodothyronine I (DIO1), and thyroid hormone receptor alpha (TRα) were also elevated in all fluoride-exposed ..
  23. Pappalardo A, Porreca I, Caputi L, De Felice E, Schulte Merker S, Zannini M, et al. Thyroid development in zebrafish lacking Taz. Mech Dev. 2015;138 Pt 3:268-78 pubmed publisher
    ..These findings indicate that the zebrafish Taz protein is needed for the normal differentiation of the thyroid and are the first to suggest that Taz confers growth advantage to the endocrine gland. ..
  24. Yan W, Zhou Y, Yang J, Li S, Hu D, Wang J, et al. Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2012;87:1301-7 pubmed publisher
    ..e., corticotropin-releasing factor (CRF), thyroid-stimulating hormone (TSH), sodium/iodide symporter (NIS), thyroglobulin (TG), thyroid receptors (TR? and TR?) and iodothyronine deiodinases (Dio1 and Dio2) was examined ..
  25. de Filippis T, Marelli F, Nebbia G, Porazzi P, Corbetta S, Fugazzola L, et al. JAG1 Loss-Of-Function Variations as a Novel Predisposing Event in the Pathogenesis of Congenital Thyroid Defects. J Clin Endocrinol Metab. 2016;101:861-70 pubmed publisher
  26. Du J, Wang S, You H, Liu Z. Effects of ZnO nanoparticles on perfluorooctane sulfonate induced thyroid-disrupting on zebrafish larvae. J Environ Sci (China). 2016;47:153-164 pubmed publisher
    ..Our results also provide insight into the mechanism of disruption of the thyroid status by PFOS and nano-ZnO. ..