Gene Symbol: slc4a1b
Description: solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
Alias: solute carrier family 4 (anion exchanger), member 1b (Diego blood group), pers, solute carrier family 4 anion exchanger member 1b, zAE1b
Hwang P. Ion uptake and acid secretion in zebrafish (Danio rerio). J Exp Biol. 2009;212:1745-52 pubmed publisher
Hailey D, Roberts B, Owens K, Stewart A, Linbo T, Pujol R, et al
. Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone. PLoS Genet. 2012;8:e1002971 pubmed publisher
..The mutation in persephone maps to the chloride/bicarbonate exchanger slc4a1b and introduces a single Ser-to-Phe substitution in zSlc4a1b...
Lee Y, Yan J, Cruz S, Horng J, Hwang P. Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. Am J Physiol Cell Physiol. 2011;300:C295-307 pubmed publisher
..in the zebrafish(z) slc4 family, and the full-length cDNAs of two novel isoforms, zslc4a1b (anion exchanger, zAE1b) and zslc4a4b (Na(+)/HCO(3)(-) cotransporter, zNBCe1b), were sequenced...
Guh Y, Tseng Y, Yang C, Hwang P. Endothelin-1 regulates H?-ATPase-dependent transepithelial H? secretion in zebrafish. Endocrinology. 2014;155:1728-37 pubmed publisher
..These findings provide evidence that EDN1 signaling is involved in acid-base regulation in zebrafish and enhance our understanding of EDN1 regulation of transepithelial H? secretion in vertebrates. ..
Shmukler B, Reimold F, Heneghan J, Chen C, Zhao T, Paw B, et al
. Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Pflugers Arch. 2014;466:1605-18 pubmed publisher
..We conclude that multiple repeat elements have disrupted the 5'-end of the zebrafish ae3 gene, associated with N-terminal truncation of the protein and reduced anion transport activity. ..
Lin Y, Hung G, Wu L, Chen S, Lin L, Horng J. Anion exchanger 1b in stereocilia is required for the functioning of mechanotransducer channels in lateral-line hair cells of zebrafish. PLoS ONE. 2015;10:e0117041 pubmed publisher
..Elevating external Ca2+ (0.2 to 2 mM) neutralized the inhibition of DIDS. Taken together, this study provides solid evidence to show that AE1b in stereocilia is required for the proper functioning of MET channels. ..
Lin C, Shih T, Liu S, Hsu H, Hwang P. Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos. Front Physiol. 2015;6:328 pubmed publisher
Guh Y, Yang C, Liu S, Huang C, Hwang P. Oestrogen-related receptor Î± is required for transepithelial H+ secretion in zebrafish. Proc Biol Sci. 2016;283:20152582 pubmed publisher
..These results demonstrate, for the first time, that ERRÎ± is required for transepithelial H(+) secretion for systemic acid-base homeostasis. ..