Gene Symbol: slc40a1
Description: solute carrier family 40 (iron-regulated transporter), member 1
Alias: FPN1, slc39a1, weh, solute carrier family 40 member 1, ferroportin-1, ferroportin1, iron-regulated transporter, solute carrier family 39 (iron-regulated transporter), member 1, weissherbst
Species: zebrafish

Top Publications

  1. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt S, Moynihan J, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-81 pubmed
    ..The gene, ferroportin1, encodes a multiple-transmembrane domain protein, expressed in the yolk sac, that is a candidate for the ..
  2. Fraenkel P, Traver D, Donovan A, Zahrieh D, Zon L. Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest. 2005;115:1532-41 pubmed
    Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst (weh(Tp85c-/-)) and in patients with type 4 ..
  3. Craig P, Galus M, Wood C, McClelland G. Dietary iron alters waterborne copper-induced gene expression in soft water acclimated zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009;296:R362-73 pubmed publisher
    ..This study shows that high dietary Fe can significantly alter the genetic expression pattern of Cu transporters at the level of the gill, liver, and gastrointestinal tract...
  4. Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, et al. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development. 1996;123:311-9 pubmed
    ..The analysis of these mutants provides a powerful approach towards defining the molecular mechanisms involved in vertebrate hematopoietic development. ..
  5. Griffiths W, Cox T. Haemochromatosis: novel gene discovery and the molecular pathophysiology of iron metabolism. Hum Mol Genet. 2000;9:2377-82 pubmed the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants...
  6. De Domenico I, Vaughn M, Yoon D, Kushner J, Ward D, Kaplan J. Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations. Blood. 2007;110:3780-3 pubmed
    ..Expression of wild-type ferroportin or hepcidin-resistant ferroportin (N144H) does not affect erythropoiesis. Zebrafish provides a facile way of identifying which ferroportin mutants may lead to macrophage iron loading. ..
  7. Tao T, Shi H, Huang D, Peng J. Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. PLoS ONE. 2013;8:e58858 pubmed publisher
    ..These results demonstrate that Def functions in a cell autonomous manner during early liver development and aberrant Def protein expression might lead to disruption of the structural integrity of a normal adult liver. ..
  8. Bo L, Liu Z, Zhong Y, Huang J, Chen B, Wang H, et al. Iron deficiency anemia's effect on bone formation in zebrafish mutant. Biochem Biophys Res Commun. 2016;475:271-6 pubmed publisher
    ..But the correlation between iron deficiency and bone metabolism remains unclear. Ferroportin 1 is identified as a cellular iron exporter and required for normal iron cycling...
  9. Jiang X, Liu Z, Lin A, Xiang L, Shao J. Coordination of Bactericidal and Iron Regulatory Functions of Hepcidin in Innate Antimicrobial Immunity in a Zebrafish Model. Sci Rep. 2017;7:4265 pubmed publisher
    ..Results indicate that the induction of hepcidin leads to the decrease of iron in circulation, which eventually limits iron availability to invading microorganisms, thus contributing to host defence. ..

More Information


  1. Cooper C, Handy R, Bury N. The effects of dietary iron concentration on gastrointestinal and branchial assimilation of both iron and cadmium in zebrafish (Danio rerio). Aquat Toxicol. 2006;79:167-75 pubmed
    ..content and transcript levels of the iron importer, Divalent Metal Transporter 1 (DMT1) and an iron exporter, ferroportin1, in both the gastrointestinal tract and gill were also measured...
  2. Rafiee A, Fatemi S, Jamili S, Ajdari S, Riazi Rad F, Memarnejadian A, et al. Cloning, Expression and Characterization of Zebra Fish Ferroportin in Hek 293T Cell Line. Iran J Public Health. 2012;41:79-86 pubmed
    ..Therefore this construct can be used in future iron studies. ..
  3. Hamilton J, Hatef A, Imran ul haq M, Nair N, Unniappan S, Kizhakkedathu J. Clinically approved iron chelators influence zebrafish mortality, hatching morphology and cardiac function. PLoS ONE. 2014;9:e109880 pubmed publisher
    ..5 mM. This study provides first evidence on iron chelator toxicity in early development and will help to guide our approach on better understanding the mechanism of iron chelator toxicity. ..
  4. Li X, Rhee D, Malhotra R, Mayeur C, Hurst L, Ager E, et al. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 2016;126:389-401 pubmed publisher
    ..These studies have identified drug candidates and potential therapeutic targets for the treatment of diseases of abnormal iron metabolism. ..
  5. Jiang Y, Yan Y, Wang X, Zhu G, Xu Y. Hepcidin inhibition on the effect of osteogenesis in zebrafish. Biochem Biophys Res Commun. 2016;476:1-6 pubmed publisher
    ..Most importantly, we revealed that hepcidin was capable of removing whole-body iron which facilitated larval recovery from the reductions in bone formation and osteogenesis induced by iron overload. ..
  6. Holowiecki A, O Shields B, Jenny M. Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicol Appl Pharmacol. 2016;311:74-87 pubmed publisher
    ..These results demonstrate distinct mechanisms of hmox and bvr transcriptional regulation in zebrafish, providing initial evidence of the partitioning of function of the hmox paralogs. ..