Gene Symbol: slc35b2
Description: solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
Alias: papst1, pic, zgc:64182, zgc:77349, adenosine 3'-phospho 5'-phosphosulfate transporter 1, pinscher, solute carrier family 35, member B2
Clément A, Wiweger M, von der Hardt S, Rusch M, Selleck S, Chien C, et al
. Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher. PLoS Genet. 2008;4:e1000136 pubmed publisher
..Here we show that two zebrafish mutants, dackel (dak) and pinscher (pic), have cartilage defects that strongly resemble those seen in HME patients...
Baier H, Klostermann S, Trowe T, Karlstrom R, Nusslein Volhard C, Bonhoeffer F. Genetic dissection of the retinotectal projection. Development. 1996;123:415-25 pubmed
..The results of this screen show that a large-scale genetic approach can be applied to relatively late and circumscribed developmental processes in the vertebrate brain. ..
Culverwell J, Karlstrom R. Making the connection: retinal axon guidance in the zebrafish. Semin Cell Dev Biol. 2002;13:497-506 pubmed
..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain. ..
Wiweger M, Avramut C, de Andrea C, Prins F, Koster A, Ravelli R, et al
. Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders. J Pathol. 2011;223:531-42 pubmed publisher
..in proteoglycan synthesis: dackel (dak/ext2), lacking heparan sulphate; hi307 (?3gat3), deficient for most GAGs; pinscher (pic/slc35b2), presenting defective sulphation of GAGs and other molecules; hi954 (uxs1), lacking Notch and most ..
de Andrea C, Prins F, Wiweger M, Hogendoorn P. Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. J Pathol. 2011;224:160-8 pubmed publisher
..identified as a model for human multiple osteochondromas; hi307 (?3gat3), deficient for most glycosaminoglycans; pinscher (pic/slc35b2), presenting with defective sulphation of glycosaminoglycans; hi954 (uxs1), lacking most ..
Wiweger M, Zhao Z, van Merkesteyn R, Roehl H, Hogendoorn P. HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas. PLoS ONE. 2012;7:e29734 pubmed publisher
..The presence of the malformed and/or displaced teeth with abnormal enamel was declared by half of the respondents indicating that MO might indeed be also associated with dental problems. ..
Karlstrom R, Trowe T, Klostermann S, Baier H, Brand M, Crawford A, et al
. Zebrafish mutations affecting retinotectal axon pathfinding. Development. 1996;123:427-38 pubmed
..Class IV mutant larvae (boxer, dackel, pinscher) have defects in axon sorting after the midline and retinal axons occasionally make further pathfinding errors ..
Neuhauss S. Behavioral genetic approaches to visual system development and function in zebrafish. J Neurobiol. 2003;54:148-60 pubmed
..Here, I summarize visually mediated behaviors of both larval and adult zebrafish and their applicability for genetic screens, and present, the approaches and results of visual behavior carried out to date. ..