Gene Symbol: slc32a1
Description: solute carrier family 32 (GABA vesicular transporter), member 1
Alias: zgc:158324, vesicular inhibitory amino acid transporter, viaat
Hirata H, Ogino K, Yamada K, Leacock S, Harvey R. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. J Neurosci. 2013;33:14638-44 pubmed publisher
..To our knowledge, this is the first identification of pathologically relevant substrates for an RNA helicase...
Roy N, Arpie B, Lugo J, Linney E, Levin E, Cerutti D. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicol Teratol. 2012;34:587-91 pubmed publisher
..Taken together, these data show that a short embryonic exposure to a neurotoxicant can alter development of neural synapses and lead to changes in adult behavior. ..
Ganser L, Yan Q, James V, Kozol R, Topf M, Harvey R, et al
. Distinct phenotypes in zebrafish models of human startle disease. Neurobiol Dis. 2013;60:139-51 pubmed publisher
..Based on our findings, future studies that aim to model candidate startle disease genes in zebrafish should include measures of spasticity and synaptic development...
JuÃ¡rez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al
. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
..These results significantly increase our understanding of the mechanisms of neuronal specification and the genetic networks involved in these processes. ..
Xia Z, Wei J, Li Y, Wang J, Li W, Wang K, et al
. Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. PLoS Genet. 2017;13:e1006892 pubmed publisher
..These findings suggest that either activating ATP2C1 or restoring the Mn-induced trafficking of ATP2C1 can reduce Mn accumulation, providing a possible target for treating HMDPC. ..
Klaassen L, Sun Z, Steijaert M, Bolte P, Fahrenfort I, Sjoerdsma T, et al
. Synaptic transmission from horizontal cells to cones is impaired by loss of connexin hemichannels. PLoS Biol. 2011;9:e1001107 pubmed publisher
..This is an important step in resolving a long-standing debate about the unusual form of (ephaptic) synaptic transmission between horizontal cells and cones in the vertebrate retina. ..
Hilinski W, Bostrom J, England S, Juárez Morales J, De Jager S, Armant O, et al
. Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Dev. 2016;11:16 pubmed publisher
..Taken together, our data significantly enhance our understanding of how spinal cord neurotransmitter fates are regulated. ..
Kimura Y, Okamura Y, Higashijima S. alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. J Neurosci. 2006;26:5684-97 pubmed
..Collectively, our data demonstrate that alx marks ipsilateral descending neurons that are involved in the regulation of motoneuron activity during forms of locomotion, such as escape and swimming. ..
Sarty K, Cowie A, Martyniuk C. The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2017;194:37-47 pubmed publisher
..This is an important consideration when incorporating transcriptomics into embryo testing as expression levels can change with removal of the chorion prior to exposure. ..