Gene Symbol: slc2a2
Description: solute carrier family 2 (facilitated glucose transporter), member 2
Alias: glut2, wu:fb62h10, solute carrier family 2, facilitated glucose transporter member 2, zglut2
Castillo J, Crespo D, Capilla E, Diaz M, Chauvigné F, Cerdà J, et al
. Evolutionary structural and functional conservation of an ortholog of the GLUT2 glucose transporter gene (SLC2A2) in zebrafish. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1570-81 pubmed publisher
In mammals, GLUT2 plays an essential role in glucose homeostasis. From an evolutionary perspective, relatively little is known about the biology of GLUT2, or other GLUTs, in nonmammalian vertebrates...
Ngan A, Wang Y. Tissue-specific transcriptional regulation of monocarboxylate transporters (MCTs) during short-term hypoxia in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:396-405 pubmed publisher
..This study has shown that fish utilize tissue-specific transcriptional regulation of MCTs along with other metabolic genes during hypoxia. ..
Michel M, Page McCaw P, Chen W, Cone R. Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proc Natl Acad Sci U S A. 2016;113:3084-9 pubmed publisher
Meng X, Chen B, Zhang J. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. Int J Biol Sci. 2017;13:985-995 pubmed publisher
Tseng Y, Chen R, Lee J, Liu S, Lee S, Hwang P. Specific expression and regulation of glucose transporters in zebrafish ionocytes. Am J Physiol Regul Integr Comp Physiol. 2009;297:R275-90 pubmed publisher
..Taken together, zGLUT1a, -6, and 13.1, the specific transporters in NaR/NCC cells, GR cells, and HR cells, may absorb glucose into the respective cells to fulfill different physiological demands. ..
Liu L, Fox C, North T, Goessling W. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Dis Model Mech. 2013;6:1271-8 pubmed publisher
..decreased expression of hepatic progenitor cells, whereas knockdown of eight genes (pnpla3, cpn1, trib1, fads2, slc2a2, pklr, mapk10 and samm50) decreased cell-specific hepatocyte expression...
MarÃn Juez R, Rovira M, Crespo D, van der Vaart M, Spaink H, Planas J. GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish. J Cereb Blood Flow Metab. 2015;35:74-85 pubmed publisher
Glucose transporter 2 (GLUT2; gene name SLC2A2) has a key role in the regulation of glucose dynamics in organs central to metabolism...
Karanth S, Zinkhan E, Hill J, Yost H, Schlegel A. FOXN3 Regulates Hepatic Glucose Utilization. Cell Rep. 2016;15:2745-55 pubmed publisher
..Human FOXN3 binds DNA sequences in the human MYC and zebrafish mycb loci. We conclude that the rs8004664 risk allele drives excessive expression of FOXN3 during fasting and that FOXN3 regulates fasting blood glucose. ..