Gene Symbol: slc25a37
Description: solute carrier family 25 (mitochondrial iron transporter), member 37
Alias: fc73c03, frs, mfrn, mfrn1, wu:fc73c03, mitoferrin-1, erythroid-specific mitochondrial mitoferrin, frascati, mfrn 1, mitochondrial iron transporter 1, mitoferrin, protein frascati, solute carrier family 25, member 37
Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al
. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed
..mutated in the frs mutant is a member of the vertebrate mitochondrial solute carrier family (SLC25) that we call mitoferrin (mfrn). mfrn is highly expressed in fetal and adult haematopoietic tissues of zebrafish and mouse...
Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, et al
. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development. 1996;123:311-9 pubmed
..Mutations in five genes, chablis, frascati, merlot, retsina, thunderbird and two possibly unique mutations cause a progressive decrease in the number of ..
Metzendorf C, Wu W, Lind M. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Biochem J. 2009;421:463-71 pubmed publisher
..In the present study we identified a single mitoferrin gene (dmfrn) in the genome of Drosophila melanogaster, which is probably an orthologue of mfrn2...
Wang Y, Langer N, Shaw G, Yang G, Li L, Kaplan J, et al
. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Exp Hematol. 2011;39:784-94 pubmed publisher
..The major focus was mitoferrin-1 (MFRN1), the mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, ..
Chen Y, Chao C, Liu F, Hsu P, Chen H, Peng S, et al
. Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study. PLoS ONE. 2013;8:e72483 pubmed publisher
..Such global, inter-species evidence of virulence-immune and iron competition dynamics during C. albicans infection could be crucial in understanding control fungal pathogenesis...
Kardon J, Yien Y, Huston N, Branco D, Hildick Smith G, Rhee K, et al
. Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. Cell. 2015;161:858-67 pubmed publisher
..mtClpX, therefore, is a widely conserved stimulator of an essential biosynthetic pathway and uses a previously unrecognized mechanism for AAA+ unfoldases. ..
Zhou X, Zhang T, Ren L, Wu J, Wang W, Liu J. Copper elevated embryonic hemoglobin through reactive oxygen species during zebrafish erythrogenesis. Aquat Toxicol. 2016;175:1-11 pubmed publisher
..Moreover, we revealed that copper homeostasis was broken by its induced ROS and ROS helped with copper overloading in the body, which could be applied as a novel therapy target for copper-caused diseases. ..
Amigo J, Ackermann G, Cope J, Yu M, Cooney J, Ma D, et al
. The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 2009;114:4654-63 pubmed publisher
..One of these enhancers contains functional GATA-binding sites, indicating the potential for a regulatory loop in which GATA factors control the expression of their partner protein FOG-1. ..