slc17a7a

Summary

Gene Symbol: slc17a7a
Description: solute carrier family 17 (vesicular glutamate transporter), member 7a
Alias: slc17a7, vglut1, vesicular glutamate transporter 1, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, solute carrier family 17 (vesicular glutamate transporter), member 7
Species: zebrafish

Top Publications

  1. Higashijima S, Mandel G, Fetcho J. Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol. 2004;480:1-18 pubmed
    ..The differences in the distribution of excitatory and inhibitory neurons in spinal cord versus hindbrain may be tied to differences in their patterns of development and functional organization. ..
  2. Volkmann K, Rieger S, Babaryka A, Köster R. The zebrafish cerebellar rhombic lip is spatially patterned in producing granule cell populations of different functional compartments. Dev Biol. 2008;313:167-80 pubmed
    ..Thus, our findings offer an explanation for how specific functional cerebellar circuitries are laid down by spatio-temporal patterning of cerebellar germinal zones during early brain development. ..
  3. Kyöstilä K, Syrjä P, Jagannathan V, Chandrasekar G, Jokinen T, Seppälä E, et al. A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease. PLoS Genet. 2015;11:e1005169 pubmed publisher
    ..Furthermore, our results reveal a novel candidate gene for human neurodegeneration and enable the development of a genetic test for veterinary diagnostic and breeding purposes. ..
  4. Van Ryswyk L, Simonson L, Eisen J. The role of inab in axon morphology of an identified zebrafish motoneuron. PLoS ONE. 2014;9:e88631 pubmed publisher
    ..We show that inab is necessary for proper axon morphology of a specific motoneuron subtype. ..
  5. Seredick S, Van Ryswyk L, Hutchinson S, Eisen J. Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Dev. 2012;7:35 pubmed publisher
    ..This is, to our knowledge, the first report of transcription factors that act to distinguish CaP and MiP subtype identities. Our results also suggest that MiP motoneurons are more similar to V2 interneurons than are CaP motoneurons. ..
  6. Zhang C, Ojiaku P, Cole G. Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function. Birth Defects Res A Clin Mol Teratol. 2013;97:8-27 pubmed publisher
  7. Furlan G, Cuccioli V, Vuillemin N, Dirian L, Muntasell A, Coolen M, et al. Life-Long Neurogenic Activity of Individual Neural Stem Cells and Continuous Growth Establish an Outside-In Architecture in the Teleost Pallium. Curr Biol. 2017;27:3288-3301.e3 pubmed publisher
  8. Obholzer N, Wolfson S, Trapani J, Mo W, Nechiporuk A, Busch Nentwich E, et al. Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci. 2008;28:2110-8 pubmed publisher
    ..A second transporter gene, vglut1, is also expressed in zebrafish hair cells, but the level of vglut1 mRNA is not increased in the absence of Vglut3...
  9. Liu J, Merkle F, Gandhi A, Gagnon J, Woods I, Chiu C, et al. Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development. 2015;142:1113-24 pubmed publisher
    ..Our results elucidate an evolutionarily conserved role for Lhx9 in Hcrt neuron specification that improves our understanding of Hcrt neuron development. ..

More Information

Publications19

  1. Rieger S, Senghaas N, Walch A, Köster R. Cadherin-2 controls directional chain migration of cerebellar granule neurons. PLoS Biol. 2009;7:e1000240 pubmed publisher
  2. Villar Cerviño V, Rocancourt C, Menuet A, Da Silva C, Wincker P, Anadón R, et al. A vesicular glutamate transporter in lampreys: cDNA cloning and early expression in the nervous system. J Chem Neuroanat. 2010;40:71-81 pubmed publisher
    ..Comparison of the early expression of VGluT genes between the lamprey and some anamniotan gnathostomes (frog, zebrafish) reveals a conserved expression pattern, likely to reflect ancestral vertebrate characteristics...
  3. Aoki T, Kinoshita M, Aoki R, Agetsuma M, Aizawa H, Yamazaki M, et al. Imaging of neural ensemble for the retrieval of a learned behavioral program. Neuron. 2013;78:881-94 pubmed publisher
    ..Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning. ..
  4. Sundvik M, Kudo H, Toivonen P, Rozov S, Chen Y, Panula P. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB J. 2011;25:4338-47 pubmed publisher
    ..development via histamine receptor H1 in zebrafish...
  5. Appelbaum L, Wang G, Maro G, Mori R, Tovin A, Marin W, et al. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. Proc Natl Acad Sci U S A. 2009;106:21942-7 pubmed publisher
    ..These results demonstrate the existence of a functional HCRT neurons-pineal gland circuit able to modulate melatonin production and sleep consolidation. ..
  6. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, et al. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol. 2007;5:e277 pubmed
    ..Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates. ..
  7. Bae Y, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y, et al. Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol. 2009;330:406-26 pubmed publisher
    ..The glutamatergic neurons are vglut1(+) granule cells and vglut2(high) cells, which receive Purkinje cell inputs; some vglut2(high) cells are ..
  8. Vaithianathan T, Henry D, Akmentin W, Matthews G. Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone. elife. 2016;5: pubmed publisher
    ..The combination of these functions allows the ribbon-type CAZ to achieve the continuous transmitter release required by synapses of neurons that carry tonic, graded visual signals in the retina. ..
  9. Chen S, Reichert S, Singh C, Oikonomou G, Rihel J, Prober D. Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 2017;95:153-168.e6 pubmed publisher
    ..These results suggest that Prok2 antagonizes the direct wake-promoting effect of light in zebrafish, in part through the induction of galn expression in the hypothalamus. ..
  10. Smear M, Tao H, Staub W, Orger M, Gosse N, Liu Y, et al. Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish. Neuron. 2007;53:65-77 pubmed
    ..Our studies successfully link the disruption of a synaptic protein to complex changes in neural circuitry and behavior. ..