slc17a6b

Summary

Gene Symbol: slc17a6b
Description: solute carrier family 17 (vesicular glutamate transporter), member 6b
Alias: VGLUT2.1, blu, si:packt73.2, si:packt90.2, si:xx-packt73.2, slc17a6, vglut2a, vesicular glutamate transporter 2.1, blumenkohl, protein blumenkohl, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b, solute carrier family 17 member 6 A, solute carrier family 17 member 6-B, vesicular glutamate transporter 2-A
Species: zebrafish

Top Publications

  1. Satou C, Kimura Y, Higashijima S. Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. J Neurosci. 2012;32:1771-83 pubmed publisher
    ..These results suggest that multiple types of V0 neurons are produced by two distinct mechanisms; from heterogeneous p0 progenitors and from the same p0 progenitor, but in a time-dependent manner. ..
  2. Seredick S, Van Ryswyk L, Hutchinson S, Eisen J. Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Dev. 2012;7:35 pubmed publisher
    ..This is, to our knowledge, the first report of transcription factors that act to distinguish CaP and MiP subtype identities. Our results also suggest that MiP motoneurons are more similar to V2 interneurons than are CaP motoneurons. ..
  3. Yang L, Rastegar S, Strahle U. Regulatory interactions specifying Kolmer-Agduhr interneurons. Development. 2010;137:2713-22 pubmed publisher
    ..Instead, olig2 and gata3 are required for the differentiation of gad67-expressing KA' cells. This suggests that the layout of regulatory networks is crucially dependent on the lineage that differs between KA' and KA' cells. ..
  4. Higashijima S, Mandel G, Fetcho J. Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol. 2004;480:1-18 pubmed
    ..The differences in the distribution of excitatory and inhibitory neurons in spinal cord versus hindbrain may be tied to differences in their patterns of development and functional organization. ..
  5. Higashijima S, Schaefer M, Fetcho J. Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. J Comp Neurol. 2004;480:19-37 pubmed
    ..Our approach allowed us to define the likely transmitter phenotypes of most of the known classes of spinal interneurons. These data provide a foundation for understanding the functional organization of the spinal networks in zebrafish. ..
  6. Kimura Y, Okamura Y, Higashijima S. alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. J Neurosci. 2006;26:5684-97 pubmed
    ..Collectively, our data demonstrate that alx marks ipsilateral descending neurons that are involved in the regulation of motoneuron activity during forms of locomotion, such as escape and swimming. ..
  7. Scholpp S, Delogu A, Gilthorpe J, Peukert D, Schindler S, Lumsden A. Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proc Natl Acad Sci U S A. 2009;106:19895-900 pubmed publisher
    ..Thus, the presence or absence of a single upstream regulator of proneural gene expression, Her6, leads to the establishment of discrete neuronal domains in the thalamus. ..
  8. Bae Y, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y, et al. Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol. 2009;330:406-26 pubmed publisher
    ..Our data provide a platform for future studies of zebrafish cerebellar development. ..
  9. Satou C, Kimura Y, Hirata H, Suster M, Kawakami K, Higashijima S. Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development. 2013;140:3927-31 pubmed publisher

More Information

Publications47

  1. Batista M, Jacobstein J, Lewis K. Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. Dev Biol. 2008;322:263-75 pubmed publisher
    ..In addition, we demonstrate that Notch signalling is required for V2 cells to develop into V2b cells. In the absence of Notch signalling, all V2b cells develop as V2a cells. ..
  2. Amo R, Fredes F, Kinoshita M, Aoki R, Aizawa H, Agetsuma M, et al. The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Neuron. 2014;84:1034-48 pubmed publisher
    ..Thus, vHb-MR circuit is essential for representing the level of expected danger and behavioral programming to adaptively avoid potential hazard. ..
  3. Volkmann K, Chen Y, Harris M, Wullimann M, Köster R. The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. J Comp Neurol. 2010;518:2794-817 pubmed publisher
  4. Furlan G, Cuccioli V, Vuillemin N, Dirian L, Muntasell A, Coolen M, et al. Life-Long Neurogenic Activity of Individual Neural Stem Cells and Continuous Growth Establish an Outside-In Architecture in the Teleost Pallium. Curr Biol. 2017;27:3288-3301.e3 pubmed publisher
  5. Koyama M, Kinkhabwala A, Satou C, Higashijima S, FETCHO J. Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proc Natl Acad Sci U S A. 2011;108:1170-5 pubmed publisher
    ..Many different specialized hindbrain networks may arise similarly from a simple early patterning. ..
  6. Coppola E, D Autréaux F, Nomaksteinsky M, Brunet J. Phox2b expression in the taste centers of fish. J Comp Neurol. 2012;520:3633-49 pubmed publisher
  7. Gabriel J, Trivedi C, Maurer C, Ryu S, Bollmann J. Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum. Neuron. 2012;76:1147-60 pubmed publisher
    ..Hence, different directions are represented in different layers, which suggests a simple mechanism for how tectal neurons acquire directional tuning in a nascent circuit. ..
  8. Moly P, Ikenaga T, Kamihagi C, Islam A, Hatta K. Identification of initially appearing glycine-immunoreactive neurons in the embryonic zebrafish brain. Dev Neurobiol. 2014;74:616-32 pubmed publisher
    ..These results provide evidence of identifiable glycinergic (Gly-ir/glyt2-positive) neurons in vertebrate embryos, and they can be used in further studies of the neurons' development and function at the single-cell level...
  9. Filippi A, Mueller T, Driever W. vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain. J Comp Neurol. 2014;522:2019-37 pubmed publisher
  10. Van Ryswyk L, Simonson L, Eisen J. The role of inab in axon morphology of an identified zebrafish motoneuron. PLoS ONE. 2014;9:e88631 pubmed publisher
    ..We show that inab is necessary for proper axon morphology of a specific motoneuron subtype. ..
  11. Kimura Y, Hisano Y, Kawahara A, Higashijima S. Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Sci Rep. 2014;4:6545 pubmed publisher
    ..Due to its simplicity, design flexibility, and high efficiency, we propose that CRISPR/Cas9-mediated knock-in will become a standard method for the generation transgenic zebrafish. ..
  12. May M, Hwang K, MILES J, Williams C, Niranjan T, Kahler S, et al. ZC4H2, an XLID gene, is required for the generation of a specific subset of CNS interneurons. Hum Mol Genet. 2015;24:4848-61 pubmed publisher
    ..Our findings clearly support ZC4H2 as a novel XLID gene with a required function in interneuron development. Loss of function of ZC4H2 thus likely results in altered connectivity of many brain and spinal circuits. ..
  13. Nathan F, Ogawa S, Parhar I. Neuronal connectivity between habenular glutamate-kisspeptin1 co-expressing neurons and the raphe 5-HT system. J Neurochem. 2015;135:814-29 pubmed publisher
  14. Baier H, Klostermann S, Trowe T, Karlstrom R, Nusslein Volhard C, Bonhoeffer F. Genetic dissection of the retinotectal projection. Development. 1996;123:415-25 pubmed
    ..The results of this screen show that a large-scale genetic approach can be applied to relatively late and circumscribed developmental processes in the vertebrate brain. ..
  15. Culverwell J, Karlstrom R. Making the connection: retinal axon guidance in the zebrafish. Semin Cell Dev Biol. 2002;13:497-506 pubmed
    ..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain. ..
  16. Smear M, Tao H, Staub W, Orger M, Gosse N, Liu Y, et al. Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish. Neuron. 2007;53:65-77 pubmed
    ..We show here that zebrafish blumenkohl (blu) mutants are impaired in resolving rapid movements and fine spatial detail...
  17. Mione M, Baldessari D, Deflorian G, Nappo G, Santoriello C. How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish. Dev Neurosci. 2008;30:65-81 pubmed
    ..These examples reinforce the concept that migratory events contribute to the distribution of cell types with diverse identities through the CNS and that zebrafish transgenic lines represent excellent tools to study these events. ..
  18. Villar Cerviño V, Rocancourt C, Menuet A, Da Silva C, Wincker P, Anadón R, et al. A vesicular glutamate transporter in lampreys: cDNA cloning and early expression in the nervous system. J Chem Neuroanat. 2010;40:71-81 pubmed publisher
    ..Comparison of the early expression of VGluT genes between the lamprey and some anamniotan gnathostomes (frog, zebrafish) reveals a conserved expression pattern, likely to reflect ancestral vertebrate characteristics...
  19. Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development. 1996;123:1-36 pubmed
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish. ..
  20. Hilinski W, Bostrom J, England S, Juárez Morales J, De Jager S, Armant O, et al. Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Dev. 2016;11:16 pubmed publisher
    ..Taken together, our data significantly enhance our understanding of how spinal cord neurotransmitter fates are regulated. ..
  21. Chen A, Chiu C, Mosser E, Kahn S, Spence R, Prober D. QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish. J Neurosci. 2016;36:1823-40 pubmed publisher
    ..We also show that QRFP overexpression reduces locomotor activity, whereas animals that lack QRFP signaling are more active and sleep less. These results suggest that QRFP signaling participates in the hypothalamic regulation of sleep. ..
  22. Neuhauss S, Biehlmaier O, Seeliger M, Das T, Kohler K, Harris W, et al. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci. 1999;19:8603-15 pubmed
    ..malfunction (noir, dropje, and possibly steifftier), and disruption of retinotectal impulse activity (macho and blumenkohl)...
  23. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, et al. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol. 2007;5:e277 pubmed
    ..Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates. ..
  24. Obholzer N, Wolfson S, Trapani J, Mo W, Nechiporuk A, Busch Nentwich E, et al. Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci. 2008;28:2110-8 pubmed publisher
    ..Lack of postsynaptic action currents in the mutants suggests that the remaining hair-cell synaptic vesicles contain insufficient levels of glutamate for generation of action potentials in first-order neurons. ..
  25. Appelbaum L, Wang G, Maro G, Mori R, Tovin A, Marin W, et al. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. Proc Natl Acad Sci U S A. 2009;106:21942-7 pubmed publisher
    ..These results demonstrate the existence of a functional HCRT neurons-pineal gland circuit able to modulate melatonin production and sleep consolidation. ..
  26. Ito Y, Tanaka H, Okamoto H, Ohshima T. Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum. Dev Biol. 2010;342:26-38 pubmed publisher
    ..These results demonstrate that the proliferating cells in the PGZ contribute to neuronal and glial lineages to maintain the structure of the optic tectum in adult zebrafish. ..
  27. Kani S, Bae Y, Shimizu T, Tanabe K, Satou C, Parsons M, et al. Proneural gene-linked neurogenesis in zebrafish cerebellum. Dev Biol. 2010;343:1-17 pubmed publisher
    ..Our data indicate that proneural gene-linked neurogenesis is evolutionarily conserved in the cerebellum among vertebrates, and that the continuously generated neurons help remodel neural circuits in the adult zebrafish cerebellum. ..
  28. Aoki T, Kinoshita M, Aoki R, Agetsuma M, Aizawa H, Yamazaki M, et al. Imaging of neural ensemble for the retrieval of a learned behavioral program. Neuron. 2013;78:881-94 pubmed publisher
    ..Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning. ..
  29. Roy N, Arpie B, Lugo J, Linney E, Levin E, Cerutti D. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicol Teratol. 2012;34:587-91 pubmed publisher
    ..Taken together, these data show that a short embryonic exposure to a neurotoxicant can alter development of neural synapses and lead to changes in adult behavior. ..
  30. Lee G, Sung S, Chang W, Kao T, Du H, Hsiao T, et al. Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. Dis Model Mech. 2012;5:785-95 pubmed publisher
    ..In conclusion, our data suggests that this ginkgotoxin-induced seizure in zebrafish larvae could serve as an in vivo model for epileptic seizure research and potential AED screening. ..
  31. Miyasaka N, Morimoto K, Tsubokawa T, Higashijima S, Okamoto H, Yoshihara Y. From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. J Neurosci. 2009;29:4756-67 pubmed publisher
    ..Moreover, our finding of asymmetric bulbo-habenular projection renders the olfactory system an attractive model for the studies of brain asymmetry and lateralized behaviors. ..
  32. Trowe T, Klostermann S, Baier H, Granato M, Crawford A, Grunewald B, et al. Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development. 1996;123:439-50 pubmed
    ..In 27 mutants belonging to six complementation groups, retinal axons do not form normal termination fields. Some implications for models concerning the formation of topographic projections are discussed. ..
  33. Sundvik M, Kudo H, Toivonen P, Rozov S, Chen Y, Panula P. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB J. 2011;25:4338-47 pubmed publisher
    ..development via histamine receptor H1 in zebrafish...
  34. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..These results significantly increase our understanding of the mechanisms of neuronal specification and the genetic networks involved in these processes. ..
  35. Fernandes A, Beddows E, Filippi A, Driever W. Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish. PLoS ONE. 2013;8:e75002 pubmed publisher
    ..Otp may thus be crucial for defined neuronal cell types also in the hindbrain. ..
  36. Batista M, Lewis K. Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Dev Biol. 2008;323:88-97 pubmed publisher
  37. Neuhauss S. Behavioral genetic approaches to visual system development and function in zebrafish. J Neurobiol. 2003;54:148-60 pubmed
    ..Here, I summarize visually mediated behaviors of both larval and adult zebrafish and their applicability for genetic screens, and present, the approaches and results of visual behavior carried out to date. ..
  38. Moreno R, Ribera A. Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability. Neural Dev. 2014;9:19 pubmed publisher