slc11a2

Summary

Gene Symbol: slc11a2
Description: solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Alias: DMT1, cb426, fa07b10, wu:fa07b10, zgc:136699, natural resistance-associated macrophage protein 2, cdy, chardonnay, nramp, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Species: zebrafish
Products:     slc11a2

Top Publications

  1. Donovan A, Brownlie A, Dorschner M, Zhou Y, Pratt S, Paw B, et al. The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood. 2002;100:4655-9 pubmed
    ..Here we characterized the phenotype of chardonnay (cdy), a zebrafish mutant with hypochromic, microcytic anemia, and positioned the mutant gene on linkage group ..
  2. Craig P, Galus M, Wood C, McClelland G. Dietary iron alters waterborne copper-induced gene expression in soft water acclimated zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009;296:R362-73 pubmed publisher
    ..This study shows that high dietary Fe can significantly alter the genetic expression pattern of Cu transporters at the level of the gill, liver, and gastrointestinal tract...
  3. Cooper C, Handy R, Bury N. The effects of dietary iron concentration on gastrointestinal and branchial assimilation of both iron and cadmium in zebrafish (Danio rerio). Aquat Toxicol. 2006;79:167-75 pubmed
    ..Carcass metal content and transcript levels of the iron importer, Divalent Metal Transporter 1 (DMT1) and an iron exporter, ferroportin1, in both the gastrointestinal tract and gill were also measured...
  4. Duan Z, Xing Y, Feng Z, Zhang H, Li C, Gong Z, et al. Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio. Environ Pollut. 2017;224:706-713 pubmed publisher
    ..Based on the determination of Cd bioaccumulation in fish and the complexing stability constant (?) of Cd-BTR complex in solution, the detoxification mechanism of co-existing 1H-BTR on Cd to the zebrafish was discussed. ..
  5. Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, et al. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development. 1996;123:311-9 pubmed
    ..Mutations in another seven genes, chardonnay, chianti, grenache, sauternes, weiflherbst and zinfandel, and two additional mutations result in hypochromic ..
  6. Boyle D, Hogstrand C, Bury N. Physiological response to a metal-contaminated invertebrate diet in zebrafish: importance of metal speciation and regulation of metal transport pathways. Aquat Toxicol. 2011;105:21-8 pubmed publisher
    ..were also taken for mRNA expression analysis of copper transporter 1 (ctr1), divalent metal transporter 1 (dmt1) and metallothionein 2 (mt2)...
  7. Tang S, Allagadda V, Chibli H, Nadeau J, Mayer G. Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate, zinc sulfate and quantum dots. Metallomics. 2013;5:1411-22 pubmed publisher
    ..This implies that ZnS shells reduce QD toxicity attributed to the release of Cd(2+), but do not eliminate toxic effects caused by the nanoparticles themselves. ..
  8. Komjarova I, Bury N. Evidence of common cadmium and copper uptake routes in zebrafish Danio rerio. Environ Sci Technol. 2014;48:12946-51 pubmed publisher
    ..levels of genes involved in the transport of Cu (CTR1 and ATP7A), Na (NHE-2), Ca (ECaC), divalent metals (DMT1), and Zn (ZIP8) were also compared between treatments at 24 and 48 h...
  9. Tuschl K, Meyer E, Valdivia L, Zhao N, Dadswell C, Abdul Sada A, et al. Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nat Commun. 2016;7:11601 pubmed publisher
    ..Chelation with disodium calcium edetate lowers blood manganese levels in patients and can lead to striking clinical improvement. Our results demonstrate that SLC39A14 functions as a pivotal manganese transporter in vertebrates. ..

More Information

Publications12

  1. Grillo A, SantaMaria A, Kafina M, Cioffi A, Huston N, Han M, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017;356:608-616 pubmed publisher
    ..The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- and mitoferrin-deficient ..
  2. White R, Collins J, Sealy I, Wali N, Dooley C, Digby Z, et al. A high-resolution mRNA expression time course of embryonic development in zebrafish. elife. 2017;6: pubmed publisher
    ..To make this dataset a useful baseline reference, the data can be browsed and downloaded at Expression Atlas and Ensembl. ..
  3. Hamilton J, Hatef A, Imran ul haq M, Nair N, Unniappan S, Kizhakkedathu J. Clinically approved iron chelators influence zebrafish mortality, hatching morphology and cardiac function. PLoS ONE. 2014;9:e109880 pubmed publisher
    ..5 mM. This study provides first evidence on iron chelator toxicity in early development and will help to guide our approach on better understanding the mechanism of iron chelator toxicity. ..