six4b

Summary

Gene Symbol: six4b
Description: SIX homeobox 4b
Alias: six4.1, six4a, six8, wu:fj32d01, SIX homeobox 4b, etID17314.20, sine oculis homeobox homolog 4.1, sine oculis homeobox homolog 4a, sine oculis homeobox homolog 4b, sine oculis homeobox homolog 8
Species: zebrafish
Products:     six4b

Top Publications

  1. Kobayashi M, Osanai H, Kawakami K, Yamamoto M. Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites. Mech Dev. 2000;98:151-5 pubmed
    ..six4.2 is expressed in the presomitic mesoderm, somites and pectoral fin bud. six4.3 appears to be a unique member of the Six4 proteins and is expressed ubiquitously at gastrulation and later in the tectum. ..
  2. Kwon H, Riley B. Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue. Dev Dyn. 2009;238:1582-94 pubmed publisher
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc. ..
  3. Esterberg R, Fritz A. dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity. Dev Biol. 2009;325:189-99 pubmed publisher
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction. ..
  4. Phillips B, Kwon H, Melton C, Houghtaling P, Fritz A, Riley B. Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Dev Biol. 2006;294:376-90 pubmed
    ..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border. ..
  5. Glavic A, Maris Honoré S, Gloria Feijóo C, Bastidas F, Allende M, Mayor R. Role of BMP signaling and the homeoprotein Iroquois in the specification of the cranial placodal field. Dev Biol. 2004;272:89-103 pubmed
  6. Feijóo C, Saldias M, De la Paz J, Gomez Skarmeta J, Allende M. Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Mol Cell Neurosci. 2009;40:328-37 pubmed publisher
    ..Our results point to irx4a as a critical gene for numerous developmental processes and highlight its role in the formation of placodal derivatives in vertebrates. ..
  7. Reichert S, Randall R, Hill C. A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Development. 2013;140:4435-44 pubmed publisher
    ..Taken together, our data define a BMP regulatory network that controls cell fate decisions at the neural plate border. ..
  8. Whitlock K, Smith K, Kim H, Harden M. A role for foxd3 and sox10 in the differentiation of gonadotropin-releasing hormone (GnRH) cells in the zebrafish Danio rerio. Development. 2005;132:5491-502 pubmed
  9. Omata Y, Nojima Y, Nakayama S, Okamoto H, Nakamura H, Funahashi J. Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development. Dev Growth Differ. 2007;49:711-9 pubmed
    ..Furthermore, the protrusions in gallery treated with Noggin were partially rescued. These data indicate that BMP4 plays an important role in the development of protrusions to form semicircular canals. ..

More Information

Publications19

  1. Van Hellemont R, Blomme T, Van de Peer Y, Marchal K. Divergence of regulatory sequences in duplicated fish genes. Genome Dyn. 2007;3:81-100 pubmed publisher
    ..In this study we used in silico motif detection to show how alterations in the composition of regulatory motifs between paralogous genes in zebrafish and Tetraodon might reflect the functional divergence of duplicates. ..
  2. Bebenek I, Gates R, Morris J, Hartenstein V, Jacobs D. sine oculis in basal Metazoa. Dev Genes Evol. 2004;214:342-51 pubmed
  3. Seo H, Drivenes O, Fjose A. A zebrafish Six4 homologue with early expression in head mesoderm. Biochim Biophys Acta. 1998;1442:427-31 pubmed
    ..We have identified a zebrafish (Danio rerio) gene, six8, which shows the greatest similarity to murine Six4...
  4. Dutta S, Dawid I. Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output. Development. 2010;137:3013-8 pubmed publisher
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range...
  5. Kwon H, Bhat N, Sweet E, Cornell R, Riley B. Identification of early requirements for preplacodal ectoderm and sensory organ development. PLoS Genet. 2010;6:e1001133 pubmed publisher
  6. Bhat N, Kwon H, Riley B. A gene network that coordinates preplacodal competence and neural crest specification in zebrafish. Dev Biol. 2013;373:107-17 pubmed publisher
    ..Thus, we have identified a gene regulatory network that coordinates development of NC, PPE and individual placodes in zebrafish. ..
  7. Langenberg T, Kahana A, Wszalek J, Halloran M. The eye organizes neural crest cell migration. Dev Dyn. 2008;237:1645-52 pubmed publisher
    ..We show that, in chokh mutants, dorsal anterior NCC migration is severely disorganized. Time-lapse analysis shows that NCCs have significantly reduced migration rates and directionality in chokh mutants. ..
  8. Harden M, Pereiro L, Ramialison M, Wittbrodt J, Prasad M, McCallion A, et al. Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing. Dev Dyn. 2012;241:1143-54 pubmed publisher
    ..We generated a six4b:mCherry line (OP precursors) that, with a sox10:EGFP line (CNCCs), was used to follow cell migration...
  9. Miyasaka N, Wanner A, Li J, Mack Bucher J, Genoud C, Yoshihara Y, et al. Functional development of the olfactory system in zebrafish. Mech Dev. 2013;130:336-46 pubmed publisher
  10. Yao D, Zhao F, Wu Y, Wang J, Dong W, Zhao J, et al. Dissecting the differentiation process of the preplacodal ectoderm in zebrafish. Dev Dyn. 2014;243:1338-51 pubmed publisher