Gene Symbol: six1b
Description: SIX homeobox 1b
Alias: six1, zgc:77345, homeobox protein six1b, homeobox protein six1a, homeodomain transcription factor six1, sine oculis homeobox homolog 1, sine oculis homeobox homolog 1a, sine oculis homeobox homolog 1b, six1a
Species: zebrafish

Top Publications

  1. Bessarab D, Chong S, Korzh V. Expression of zebrafish six1 during sensory organ development and myogenesis. Dev Dyn. 2004;230:781-6 pubmed
    ..In this study, we describe the cloning and expression of a zebrafish homolog of sine oculis, six1. The reverse transcription-polymerase chain reaction demonstrated accumulation of six1 transcripts at mid-gastrula, ..
  2. Lin C, Chen W, Lee H, Yang P, Yang H, Tsai H. The transcription factor Six1a plays an essential role in the craniofacial myogenesis of zebrafish. Dev Biol. 2009;331:152-66 pubmed publisher
    Transcription factor Six1a plays important roles in morphogenesis, organogenesis, and cell differentiation. However, the role of Six1a during zebrafish cranial muscle development is still unclear...
  3. Bessarab D, Chong S, Srinivas B, Korzh V. Six1a is required for the onset of fast muscle differentiation in zebrafish. Dev Biol. 2008;323:216-28 pubmed publisher
    ..In zebrafish, there are two close homologs of Six1: six1a (known earlier as six1) and six1b identified in this study...
  4. Henshall T, Tucker B, Lumsden A, Nornes S, Lardelli M, Richards R. Selective neuronal requirement for huntingtin in the developing zebrafish. Hum Mol Genet. 2009;18:4830-42 pubmed publisher
    ..These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types. ..
  5. Miyasaka N, Wanner A, Li J, Mack Bucher J, Genoud C, Yoshihara Y, et al. Functional development of the olfactory system in zebrafish. Mech Dev. 2013;130:336-46 pubmed publisher
  6. Pogoda H, Hammerschmidt M. How to make a teleost adenohypophysis: molecular pathways of pituitary development in zebrafish. Mol Cell Endocrinol. 2009;312:2-13 pubmed publisher
    ..most recent findings, including some thus far unpublished data from our own laboratory on the transcription factor Six1. In addition, zebrafish data will be discussed in comparison with current understanding of adenohypophysis ..
  7. Mizoguchi T, Togawa S, Kawakami K, Itoh M. Neuron and sensory epithelial cell fate is sequentially determined by Notch signaling in zebrafish lateral line development. J Neurosci. 2011;31:15522-30 pubmed publisher
    ..Since Notch signaling also affects hair cell fate determination at a later stage, our study suggests that Notch signaling has dual, time-dependent roles in specifying multiple cell types during pLL development. ..
  8. Lin C, Chen J, Loo M, Hsiao C, Chang W, Tsai H. MicroRNA-3906 regulates fast muscle differentiation through modulating the target gene homer-1b in zebrafish embryos. PLoS ONE. 2013;8:e70187 pubmed publisher
    ..These results indicate that miR-3906 controls [Ca(2+)]i homeostasis in fast muscle through fine tuning homer-1b expression during differentiation to maintain normal muscle development. ..
  9. Talbot J, Amacher S. A streamlined CRISPR pipeline to reliably generate zebrafish frameshifting alleles. Zebrafish. 2014;11:583-5 pubmed publisher

More Information


  1. Bricaud O, Collazo A. The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. J Neurosci. 2006;26:10438-51 pubmed
    ..We cloned zebrafish six1 and studied its function in inner ear development...
  2. Nord H, Nygård Skalman L, Von Hofsten J. Six1 regulates proliferation of Pax7-positive muscle progenitors in zebrafish. J Cell Sci. 2013;126:1868-80 pubmed publisher
    ..In this study, we show that two genes, belonging to the sine oculus class 1 (six1) genes (six1a and six1b), are both essential for the regulation of Pax7(+) cell proliferation and, consequently, in their ..
  3. O Brien J, Hernandez Lagunas L, Artinger K, Ford H. MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1. J Cell Sci. 2014;127:2291-301 pubmed publisher
    ..In zebrafish somites, we show that miR30a and six1a and six1b (hereafter six1a/b) are expressed in an inverse temporal pattern...
  4. Graf M, Teo Qi Wen E, Sarusie M, Rajaei F, Winkler C. Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Mol Endocrinol. 2015;29:187-99 pubmed publisher
    ..Intriguingly, its effect on gonadotrope numbers defines a first nongonadal role for a dmrt family member that appears crucial for the activity of the reproductive system. ..
  5. Nica G, Herzog W, Sonntag C, Nowak M, Schwarz H, Zapata A, et al. Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Dev Biol. 2006;292:189-204 pubmed
    The homeodomain transcription factor Six1 and its modulator, the protein phosphatase Eya1, cooperate to promote cell differentiation and survival during mouse organ development...