Gene Symbol: sigmar1
Description: sigma non-opioid intracellular receptor 1
Alias: oprs1, zgc:56378, sigma non-opioid intracellular receptor 1, opioid receptor, sigma 1, sigma 1-type opioid receptor, sigma1-receptor, sigma1R
Species: zebrafish

Top Publications

  1. Chen S, Zeng M, Sun H, Deng W, Lu Y, Tao D, et al. Zebrafish Dnd protein binds to 3'UTR of geminin mRNA and regulates its expression. BMB Rep. 2010;43:438-44 pubmed
    ..Taken together, the identification of target mRNA for ZDnd will be helpful to further explore the biological function of Dnd in zebrafish germ-line development as well as in cancer cells. ..
  2. Moritz C, Berardi F, Abate C, Peri F. Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries. Neurosci Lett. 2015;591:13-8 pubmed publisher
    ..This indicates that pharmacological manipulation of σ1 receptor modulates microglial responses providing new approaches to reduce the devastating impact that microglia have in neurodegenerative diseases. ..
  3. Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher
    ..Thus, pharmacological and genetic interrogation of the freezing response revealed ?1 as a mediator of threat responses in vertebrates. ..