Gene Symbol: sid4
Description: secreted immunoglobulin domain 4
Alias: secreted immunoglobulin domain 4
diIorio P, Runko A, Farrell C, Roy N. Sid4: A secreted vertebrate immunoglobulin protein with roles in zebrafish embryogenesis. Dev Biol. 2005;282:55-69 pubmed
..an ongoing in situ hybridization analysis of expressed sequence tags in zebrafish we identified secreted immunoglobulin domain 4 (sid4), a gene encoding a soluble vertebrate protein composed solely of four immunoglobulin domains...
diIorio P, Alexa K, Choe S, Etheridge L, SAGERSTROM C. TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm. Dev Biol. 2007;304:221-31 pubmed
..Our data indicate that meis3 and pbx4 regulate shh expression in anterior endoderm, thereby influencing patterning and growth of the foregut. ..
Alexa K, Choe S, Hirsch N, Etheridge L, Laver E, SAGERSTROM C. Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish. PLoS ONE. 2009;4:e8261 pubmed publisher
..is less affected in the mutant, with varying degrees of residual expression observed for pdx1, carbA, hhex, prox1, sid4, transferrin and ifabp. In addition, mutant embryos display a swollen pericardium and lack fin buds...
Encinas P, Rodriguez Milla M, Novoa B, Estepa A, Figueras A, Coll J. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 2010;11:518 pubmed publisher
Cox A, Saunders D, Kelsey P, Conway A, Tesmenitsky Y, Marchini J, et al
. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014;6:56-69 pubmed publisher
..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury...
Liu L, Alexa K, Cortes M, Schatzman Bone S, Kim A, Mukhopadhyay B, et al
. Cannabinoid receptor signaling regulates liver development and metabolism. Development. 2016;143:609-22 pubmed publisher
..Our work describes a novel developmental role for EC signaling, whereby Cnr-mediated regulation of Srebfs and methionine metabolism impacts liver development and function. ..