Gene Symbol: serpine1
Description: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Alias: PAI, PAI-1, PAI1, PLANH1, si:ch211-138a11.1, plasminogen activator inhibitor 1, chemokine CCL-C25s
Species: zebrafish
Products:     serpine1

Top Publications

  1. Cui S, Leyva Vega M, Tsai E, Eauclaire S, Glessner J, Hakonarson H, et al. Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology. 2013;144:1107-1115.e3 pubmed publisher
    ..Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene. These findings also support a role for Hedgehog signaling in the pathogenesis of BA. ..
  2. Bager R, Johansen J, Jensen J, Stensballe A, Jendroszek A, Buxbom L, et al. Protein conformational change delayed by steric hindrance from an N-linked glycan. J Mol Biol. 2013;425:2867-77 pubmed publisher
    ..We demonstrate that plasminogen activator inhibitor-1 (PAI-1) from zebrafish converts to the latent state about 5-fold slower than human PAI-1...
  3. Venkateswaran A, Sekhar K, Levic D, Melville D, Clark T, Rybski W, et al. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Res. 2014;74:38-43 pubmed publisher
    ..Thus, our current findings, coupled with previous research, support the hypothesis that ENOX1 represents a potential cancer therapy target, one that combines molecular targeting with cytotoxic sensitization. ..
  4. Sasaki T, Lian S, Qi J, Bayliss P, Carr C, Johnson J, et al. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS Genet. 2014;10:e1004409 pubmed publisher
    ..Thus, these results provide evidence that Spns1 operates during autophagy and senescence differentially with Beclin 1 and p53. ..
  5. Estepa A, Coll J. Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish. Fish Shellfish Immunol. 2015;47:264-70 pubmed publisher
    ..we discovered that most serpin (serine protease inhibitor) gene transcripts were upregulated, except those of serpine1. Surprisingly, only SERPINe1-derived 14-mer peptide and low molecular weight drugs targeting SERPINe1 (i.e...
  6. Liu X, Cai X, Hu B, Mei Z, Zhang D, Ouyang G, et al. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). J Biol Chem. 2016;291:25692-25705 pubmed
    ..In conclusion, our findings suggest that, by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress. ..