Gene Symbol: serpine1
Description: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Alias: PAI, PAI-1, PAI1, PLANH1, si:ch211-138a11.1, plasminogen activator inhibitor 1, chemokine CCL-C25s
Cui S, Leyva Vega M, Tsai E, Eauclaire S, Glessner J, Hakonarson H, et al
. Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology. 2013;144:1107-1115.e3 pubmed publisher
..Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene. These findings also support a role for Hedgehog signaling in the pathogenesis of BA. ..
Bager R, Johansen J, Jensen J, Stensballe A, Jendroszek A, Buxbom L, et al
. Protein conformational change delayed by steric hindrance from an N-linked glycan. J Mol Biol. 2013;425:2867-77 pubmed publisher
..We demonstrate that plasminogen activator inhibitor-1 (PAI-1) from zebrafish converts to the latent state about 5-fold slower than human PAI-1...
Venkateswaran A, Sekhar K, Levic D, Melville D, Clark T, Rybski W, et al
. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Res. 2014;74:38-43 pubmed publisher
..Thus, our current findings, coupled with previous research, support the hypothesis that ENOX1 represents a potential cancer therapy target, one that combines molecular targeting with cytotoxic sensitization. ..
Sasaki T, Lian S, Qi J, Bayliss P, Carr C, Johnson J, et al
. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS Genet. 2014;10:e1004409 pubmed publisher
..Thus, these results provide evidence that Spns1 operates during autophagy and senescence differentially with Beclin 1 and p53. ..
Estepa A, Coll J. Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish. Fish Shellfish Immunol. 2015;47:264-70 pubmed publisher
..we discovered that most serpin (serine protease inhibitor) gene transcripts were upregulated, except those of serpine1. Surprisingly, only SERPINe1-derived 14-mer peptide and low molecular weight drugs targeting SERPINe1 (i.e...
Liu X, Cai X, Hu B, Mei Z, Zhang D, Ouyang G, et al
. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). J Biol Chem. 2016;291:25692-25705 pubmed
..In conclusion, our findings suggest that, by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress. ..