Gene Symbol: sema3d
Description: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Alias: sema2, semaZ2, semaphorin-3D, sema Z2, semaphorin 3d, semaphorin-2, semaphorin-Z2
Species: zebrafish

Top Publications

  1. Shanmugalingam S, Houart C, Picker A, Reifers F, Macdonald R, Barth A, et al. Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development. 2000;127:2549-61 pubmed
    ..However, as ace mutant neural plate cells still retain at least some inductive activity, then other signals must also be produced by the anterior margin of the neural plate. ..
  2. Liu Y, Halloran M. Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1. J Neurosci. 2005;25:10556-63 pubmed
    ..We show that a semaphorin expressed at the dorsal spinal cord midline, Semaphorin3D (Sema3D), may act to repel the peripheral axons out of the spinal cord...
  3. Ton Q, Kathryn Iovine M. Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration. Dev Biol. 2012;366:195-203 pubmed publisher
    ..Here we demonstrate that semaphorin3d (sema3d) functions downstream of Cx43...
  4. Seth A, Culverwell J, Walkowicz M, Toro S, Rick J, Neuhauss S, et al. belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain. Development. 2006;133:725-35 pubmed
    ..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis. ..
  5. Govindan J, Tun K, Iovine M. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS ONE. 2016;11:e0148202 pubmed publisher
    ..Moreover, we provide evidence that the Hapln1a-ECM stabilizes the secreted growth factor Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration...
  6. Miyake A, Mekata Y, Fujibayashi H, Nakanishi K, Konishi M, Itoh N. Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. PLoS ONE. 2017;12:e0176036 pubmed publisher
    ..The present results suggest that Brorin is a secreted Bmp antagonist predominantly expressed in developing neural tissues and that it plays multiple roles in the development of the zebrafish forebrain. ..
  7. Yu H, Moens C. Semaphorin signaling guides cranial neural crest cell migration in zebrafish. Dev Biol. 2005;280:373-85 pubmed
  8. Banerji R, Eble D, Iovine M, Skibbens R. Esco2 regulates cx43 expression during skeletal regeneration in the zebrafish fin. Dev Dyn. 2016;245:7-21 pubmed publisher
    ..These results conceptually link ODDD to cohesinopathies and provide evidence that ESCO2 may play a transcriptional role critical for human development. ..
  9. Kuan Y, Yu H, Moens C, Halpern M. Neuropilin asymmetry mediates a left-right difference in habenular connectivity. Development. 2007;134:857-65 pubmed
    ..Selective depletion of Sema3D, but not of other Sema family members, similarly disrupts innervation of the dorsal IPN...

More Information


  1. Sun X, Zhang R, Lin X, Xu X. Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6. Circ Res. 2008;102:831-9 pubmed publisher
    ..We propose that this function of wnt3a in r6 is partially mediated by crip2 expression in the premigratory cardiac NCCs, which subsequently affects cardiac function and PA patterning. ..
  2. Taku A, Marcaccio C, Ye W, Krause G, Raper J. Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target. Development. 2016;143:123-32 pubmed publisher
    ..In search of additional cues that guide these axons to the CZ, we found that Semaphorin 3D (Sema3D) is expressed in the anterior bulb and acts as a repellent that pushes them towards the CZ...
  3. Peukert D, Weber S, Lumsden A, Scholpp S. Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling. PLoS Biol. 2011;9:e1001218 pubmed publisher
    ..We therefore suggest that after initial neural tube patterning, neurogenesis within a brain compartment influences the integrity of the neuronal progenitor pool and border formation of a neuromeric compartment. ..
  4. Gallardo V, Liang J, Behra M, Elkahloun A, Villablanca E, Russo V, et al. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. BMC Dev Biol. 2010;10:120 pubmed publisher
  5. Govindan J, Iovine M. Hapln1a is required for connexin43-dependent growth and patterning in the regenerating fin skeleton. PLoS ONE. 2014;9:e88574 pubmed publisher
    ..Attempts to place hapln1a in our previously defined cx43-sema3d pathway suggest that hapln1a functions in a parallel genetic pathway...
  6. Paulus J, Halloran M. Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects. Dev Dyn. 2006;235:213-24 pubmed
    ..In contrast to CNS axons, most peripheral axons appear normal in bal mutants. Our results, thus, reveal important and diverse functions for laminin-alpha1 in guiding developing axons in vivo. ..
  7. Wolman M, Regnery A, Becker T, Becker C, Halloran M. Semaphorin3D regulates axon axon interactions by modulating levels of L1 cell adhesion molecule. J Neurosci. 2007;27:9653-63 pubmed
    ..Here we describe crosstalk between molecules that mediate these mechanisms. We show that Semaphorin3D (Sema3D), a classic repulsive molecule, promotes fasciculation by regulating L1 CAM levels and axon-axon interactions ..
  8. Sato M, Tsai H, Yost H. Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field. Dev Biol. 2006;298:12-21 pubmed
    ..b>Sema3D morphants have subsequent complex congenital heart defects, including hypertrophic cardiomyocytes, decreased ..
  9. Tanaka H, Nojima Y, Shoji W, Sato M, Nakayama R, Ohshima T, et al. Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons. Dev Dyn. 2011;240:9-22 pubmed publisher
    ..AMO)-mediated knockdown of dpysl3 inhibited the outgrowth of the peripheral axons of RB neurons, and semaphorin 3d (sema3d) AMO enhanced this effect...
  10. Hamm M, Kirchmaier B, Herzog W. Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1. J Cell Biol. 2016;215:415-430 pubmed
    ..Recently, SEMA3D gene disruptions were associated with cardiovascular defects in patients; however, the mechanisms of action were ..
  11. Liu Y, Berndt J, Su F, Tawarayama H, Shoji W, Kuwada J, et al. Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. J Neurosci. 2004;24:310-8 pubmed
    We examined the role of Sema3D, a semaphorin of previously unknown function, in guiding retinal ganglion cell (RGC) axons to the optic tectum in the developing zebrafish...
  12. Berndt J, Halloran M. Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain. Development. 2006;133:3983-92 pubmed
    ..Morpholino-mediated knockdown of Sema3d inhibits the proliferation of hindbrain neuroepithelial cells...
  13. Wolman M, Liu Y, Tawarayama H, Shoji W, Halloran M. Repulsion and attraction of axons by semaphorin3D are mediated by different neuropilins in vivo. J Neurosci. 2004;24:8428-35 pubmed
    ..We investigated the role of Semaphorin3D (Sema3D) in the formation of the early axon pathways in the zebrafish CNS...
  14. Samuel A, Rubinstein A, Azar T, Ben Moshe Livne Z, Kim S, Inbal A. Six3 regulates optic nerve development via multiple mechanisms. Sci Rep. 2016;6:20267 pubmed publisher
    ..Hence, the new zebrafish model for Six3 loss of function furthers our understanding of the mechanisms governing optic nerve development and Six3-mediated eye and forebrain malformations. ..
  15. Barresi M, Hutson L, Chien C, Karlstrom R. Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development. 2005;132:3643-56 pubmed
    ..glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 and sema3d, but that Hh does not appear to play a direct role in commissural and retinal axon guidance...
  16. Jiang Q, Arnold S, Heanue T, Kilambi K, Doan B, Kapoor A, et al. Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. Am J Hum Genet. 2015;96:581-96 pubmed publisher
    ..Analysis in Ret wild-type and Ret-null mice demonstrates specific expression of Sema3a, Sema3c, and Sema3d in the enteric nervous system (ENS)...
  17. Sakai J, Halloran M. Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish. Development. 2006;133:1035-44 pubmed
    ..Here we show that Sema3d, a secreted semaphorin expressed at the midline, guides the crossing of RGC axons in zebrafish...
  18. Jacobson S, BIRKHOLZ D, McNamara M, Bharate S, George K. Subacute developmental exposure of zebrafish to the organophosphate pesticide metabolite, chlorpyrifos-oxon, results in defects in Rohon-Beard sensory neuron development. Aquat Toxicol. 2010;100:101-11 pubmed publisher
  19. Jia Q, Zhang Q, Zhang Z, Wang Y, Zhang W, Zhou Y, et al. Transcriptome analysis of the zebrafish model of Diamond-Blackfan anemia from RPS19 deficiency via p53-dependent and -independent pathways. PLoS ONE. 2013;8:e71782 pubmed publisher
    ..The detection of potential pathogenic genes and pathways provides us a new paradigm for future research on DBA, which is a systematic and complex hereditary disease. ..
  20. Schlueter P, Royer T, Farah M, Laser B, Chan S, Steiner D, et al. Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors. FASEB J. 2006;20:1230-2 pubmed