Gene Symbol: sec13
Description: SEC13 homolog, nuclear pore and COPII coat complex component
Alias: cb271, sb:cb271, sec13l1, wu:fa08f09, zgc:63980, protein SEC13 homolog, SEC13 homolog, nuclear pore and COPII coating complex component, SEC13-like 1
Townley A, Feng Y, Schmidt K, Carter D, Porter R, Verkade P, et al
. Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J Cell Sci. 2008;121:3025-34 pubmed publisher
..and recruits the Sec23-Sec24 complex (Sec23/24), which is the primary cargo-binding adaptor for the system, and Sec13-Sec31 (Sec13/31), which provides a structural outer layer for vesicle formation...
Townley A, Schmidt K, Hodgson L, Stephens D. Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion. J Cell Sci. 2012;125:673-84 pubmed publisher
..Here, we show that suppression of the outer layer COPII component, Sec13, in zebrafish embryos results in a disorganized gut epithelium...
Niu X, Gao C, Jan Lo L, Luo Y, Meng C, Hong J, et al
. Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish. Dev Biol. 2012;367:197-207 pubmed publisher
The Sec13-Sec31 heterotetramer serves as the outer coat in the COPII complex, which mediates protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus...
Hinaux H, Poulain J, Da Silva C, Noirot C, Jeffery W, Casane D, et al
. De novo sequencing of Astyanax mexicanus surface fish and Pachón cavefish transcriptomes reveals enrichment of mutations in cavefish putative eye genes. PLoS ONE. 2013;8:e53553 pubmed publisher
..Based on these sequence differences, we provide a list of 11 genes that are potential candidates for having a role in cavefish visual system degeneration...
Schmidt K, Cavodeassi F, Feng Y, Stephens D. Early stages of retinal development depend on Sec13 function. Biol Open. 2013;2:256-66 pubmed publisher
..The COPII coat consists of an inner layer, Sec23/24 and an outer shell, Sec13/31. We have shown previously that knock-down of Sec13 results in concomitant loss of Sec31...