sdc4

Summary

Gene Symbol: sdc4
Description: syndecan 4
Alias: sdc4l, wu:fc47g09, syndecan-4, ryudocan core protein, syn4, syndecan 4 like
Species: zebrafish

Top Publications

  1. Matthews H, Marchant L, Carmona Fontaine C, Kuriyama S, Larraín J, Holt M, et al. Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development. 2008;135:1771-80 pubmed publisher
    ..We show that the proteoglycan Syndecan-4 (Syn4) is expressed in the migrating neural crest of Xenopus and zebrafish embryos...
  2. Müller Deile J, Gellrich F, Schenk H, Schroder P, Nyström J, Lorenzen J, et al. Overexpression of TGF-? Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans. Cell Physiol Biochem. 2016;40:819-830 pubmed
    ..In contrast, knockdown of syndecan 3 and syndecan 4 had no effects on glomerular filtration barrier...
  3. Whiteford J, Couchman J. A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain. J Biol Chem. 2006;281:32156-63 pubmed
    ..We have shown that cell adhesion to the syndecan-4 ectodomain involves beta1 integrins in several cell types. ..
  4. Mercer S, Odelberg S, Simon H. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Dev Biol. 2013;382:457-69 pubmed publisher
    ..Thus, the engineering of nature-tested extracellular matrices may provide new strategic opportunities for the enhancement of regenerative responses in mammals...
  5. Luo N, Li H, Xiang B, Qiao L, He J, Ji Y, et al. Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis. Sci Rep. 2016;6:25300 pubmed publisher
    Syndecan-4 (Syn4), a single-pass transmembrane heparin sulphate proteoglycan (HSPG), plays significant role in the formation of focal adhesions and interacts with many growth factors to regulate cell migration and neural induction...
  6. Lambaerts K, Van Dyck S, Mortier E, Ivarsson Y, Degeest G, Luyten A, et al. Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish. J Cell Sci. 2012;125:1129-40 pubmed publisher
    ..This study identifies the importance of the syntenin-syndecan-PIP2-Arf6 complex for the progression of fish epiboly and establishes its key role in directional cell movements during early development. ..
  7. Holmborn K, Habicher J, Kasza Z, Eriksson A, Filipek Gorniok B, Gopal S, et al. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem. 2012;287:33905-16 pubmed
  8. Whiteford J, Ko S, Lee W, Couchman J. Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates. J Biol Chem. 2008;283:29322-30 pubmed publisher
    ..Therefore, the cell adhesion properties of syndecan-4 are consistent across the vertebrate spectrum and reflect an early acquisition of specialization after syndecan gene duplication events at the invertebrate/early chordate boundary. ..
  9. Venero Galanternik M, Lush M, Piotrowski T. Glypican4 modulates lateral line collective cell migration non cell-autonomously. Dev Biol. 2016;419:321-335 pubmed publisher
    ..Our results show that glypican4 has distinct functions in primordium cells and cells in the environment and that both of these functions are essential for collective cell migration. ..

More Information

Publications13

  1. Damm E, Clements W. Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nat Cell Biol. 2017;19:457-467 pubmed publisher
    ..Preventing association of the NC with the DA leads to loss of HSCs. Our results define NC as key cellular components of the HSC specification niche that can be profiled to identify unknown HSC specification signals. ..
  2. Lin C, He J, Zeng C, Loo M, Chang W, Zhang P, et al. microRNA-206 modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somites to maintain and stabilize the somite boundary formation of zebrafish embryos. Open Biol. 2017;7: pubmed publisher
    ..Collectively, we suggest that miR-206 mediates a novel pathway, the Rtn4a/Cxcr4a/Thbs3a axis, that allows boundary cells to undergo MET and form somite boundaries in the newly forming somites of zebrafish embryos. ..
  3. Hofmeister W, Devine C, Key B. Distinct expression patterns of syndecans in the embryonic zebrafish brain. Gene Expr Patterns. 2013;13:126-32 pubmed publisher
    ..These genes show differing expression patterns in the brain which provides putative insights into their functional specificity. ..
  4. Venero Galanternik M, Kramer K, Piotrowski T. Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Rep. 2015;: pubmed publisher
    ..The HSPGs themselves are regulated by the Wnt/β-catenin and Fgf pathways and thus are integral components of the regulatory network that coordinates collective cell migration with organ specification and morphogenesis. ..