Gene Symbol: sdc2
Description: syndecan 2
Alias: cb440, zgc:103676, syndecan-2
Chen E, Hermanson S, Ekker S. Syndecan-2 is essential for angiogenic sprouting during zebrafish development. Blood. 2004;103:1710-9 pubmed
..Syndecan-2 as a novel angiogenic factor is a potential candidate for use in the development of angiogenesis-based therapies. ..
Lambaerts K, Van Dyck S, Mortier E, Ivarsson Y, Degeest G, Luyten A, et al
. Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish. J Cell Sci. 2012;125:1129-40 pubmed publisher
..This study identifies the importance of the syntenin-syndecan-PIP2-Arf6 complex for the progression of fish epiboly and establishes its key role in directional cell movements during early development. ..
Arrington C, Yost H. Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development. 2009;136:3143-52 pubmed publisher
..The mechanisms that regulate this process are poorly understood. Here we show that the proteoglycan syndecan 2 (Sdc2) expressed in the extra-embryonic yolk syncytial layer (YSL) acts locally at the YSL-embryo interface to ..
Holmborn K, Habicher J, Kasza Z, Eriksson A, Filipek Gorniok B, Gopal S, et al
. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem. 2012;287:33905-16 pubmed
Hofmeister W, Devine C, Key B. Distinct expression patterns of syndecans in the embryonic zebrafish brain. Gene Expr Patterns. 2013;13:126-32 pubmed publisher
..These genes show differing expression patterns in the brain which provides putative insights into their functional specificity. ..
Yokoi H, Yan Y, Miller M, Bremiller R, Catchen J, Johnson E, et al
. Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Dev Biol. 2009;329:1-15 pubmed publisher
..These roles in eye development were previously unrecognized and reinforce the multiple functions that Sox9 plays in vertebrate development. ..
Arrington C, Peterson A, Yost H. Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry. Development. 2013;140:4102-9 pubmed publisher
..Using lineage-targeted knockdowns, we found that the transmembrane HSPG Syndecan 2 (Sdc2) regulates LR patterning through cell-autonomous functions in the zebrafish ciliated organ of asymmetry, ..
Luo N, Li H, Xiang B, Qiao L, He J, Ji Y, et al
. Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis. Sci Rep. 2016;6:25300 pubmed publisher
..Collectively, these data indicate that Syn4 suppresses the cellular proliferation during neurogenesis and is crucial for the formation of CaP axons during zebrafish embryogenesis. ..
Müller Deile J, Gellrich F, Schenk H, Schroder P, Nyström J, Lorenzen J, et al
. Overexpression of TGF-? Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans. Cell Physiol Biochem. 2016;40:819-830 pubmed
..Podocyte-derived miR-143 is a mediator for paracrine and autocrine cross talk between podocytes and glomerular endothelial cells and can alter expression of glomerular glycocalyx proteins. ..