Gene Symbol: scrib
Description: scribbled planar cell polarity protein
Alias: scrb1, scribble, scribble1, si:ch211-12p8.1, si:zc12p8.1, protein scribble homolog, landlocked, llk
Walsh G, Grant P, Morgan J, Moens C. Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration. Development. 2011;138:3033-42 pubmed publisher
..with components of the WAVE regulatory complex that controls cytoskeletal dynamics and with the polarity protein Scribble, respectively...
Wada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H, et al
. Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos. Development. 2005;132:2273-85 pubmed
..green fluorescent protein (GFP) in the cranial motor neurons, we isolated two novel mutants, designated landlocked (llk) and off-road (ord), which both show highly specific defects in the caudal migration of the nVII motor ..
Vervenne H, Crombez K, Lambaerts K, Carvalho L, Köppen M, Heisenberg C, et al
. Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Dev Biol. 2008;320:267-77 pubmed publisher
..A known interaction partner of LPP in human is the tumor suppressor protein SCRIB. Knocking down scrib expression during zebrafish embryonic development results in defects of convergence and ..
Skouloudaki K, Puetz M, Simons M, Courbard J, Boehlke C, Hartleben B, et al
. Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A. 2009;106:8579-84 pubmed publisher
..Knockdown of the PDZ domain containing the adaptor protein Scribble intensified the cyst-promoting phenotype of Fat1 depletion, suggesting that Fat1 and Scribble act in overlapping ..
Zigman M, Trinh L, Fraser S, Moens C. Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions. Curr Biol. 2011;21:79-86 pubmed publisher
..We find that Scribble is required for oriented cell division and that its function in this process is independent of canonical ..
Michaelis U, Chavakis E, Kruse C, Jungblut B, Kaluza D, Wandzioch K, et al
. The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res. 2013;112:924-34 pubmed publisher
..Screening of endothelial cells revealed high expression of the polarity protein Scribble (Scrib)...
Li X, Roszko I, Sepich D, Ni M, Hamm H, Marlow F, et al
. Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development. 2013;140:3028-39 pubmed publisher
..Our study reveals a role for Gpr125 in PCP-mediated processes and provides mechanistic insight into Wnt/PCP signaling. ..
Dauber A, Golzio C, Guenot C, Jodelka F, Kibaek M, Kjaergaard S, et al
. SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant. Am J Hum Genet. 2013;93:798-811 pubmed publisher
..3. Fine mapping localized a commonly deleted 78 kb region that contains three genes: SCRIB, NRBP2, and PUF60...
Sun S, Purdy A, Walsh G. Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neurosci. 2016;17:83 pubmed
..We extend our findings to reveal a role for the PCP gene scribble in the anterior guidance of CoPA axons...