Gene Symbol: scn8aa
Description: sodium channel, voltage gated, type VIII, alpha subunit a
Alias: Nav1.6, scn8a, sodium channel, voltage gated, type VIII, alpha subunit a, sodium channel, voltage-gated, type VIII, alpha a, sodium channel, voltage-gated, type VIII, alpha polypeptide a, zscn4
Species: zebrafish

Top Publications

  1. Wright M, Ribera A. Brain-derived neurotrophic factor mediates non-cell-autonomous regulation of sensory neuron position and identity. J Neurosci. 2010;30:14513-21 pubmed publisher
    ..Overall, the results demonstrate that neurotrophins mediate non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons. ..
  2. Pineda R, Heiser R, Ribera A. Developmental, molecular, and genetic dissection of INa in vivo in embryonic zebrafish sensory neurons. J Neurophysiol. 2005;93:3582-93 pubmed
    ..Finally, analysis of macho mutants indicated that developmental upregulation of INa was absent in RB cells. These results indicate that MOs are a useful tool for the molecular dissection and analysis of ion channel function in vivo. ..
  3. Novak A, Taylor A, Pineda R, Lasda E, Wright M, Ribera A. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Dev Dyn. 2006;235:1962-73 pubmed
    ..Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues. ..
  4. Novak A, Jost M, Lu Y, Taylor A, Zakon H, Ribera A. Gene duplications and evolution of vertebrate voltage-gated sodium channels. J Mol Evol. 2006;63:208-21 pubmed publisher
    ..Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation...
  5. Pineda R, Svoboda K, Wright M, Taylor A, Novak A, Gamse J, et al. Knockdown of Nav1.6a Na+ channels affects zebrafish motoneuron development. Development. 2006;133:3827-36 pubmed
    ..Here, we focus on the zebrafish Na+ channel isotype, Nav1.6a, which is encoded by the scn8a gene...
  6. Wu S, Chen Y, Huang F, Chang C, Chang Y, Tsay H. Multiple regulatory elements mediating neuronal-specific expression of zebrafish sodium channel gene, scn8aa. Dev Dyn. 2008;237:2554-65 pubmed publisher
    Zebrafish scn8aa sodium channels mediate the majority of sodium conductance, which is essential for the embryonic locomotor activities...
  7. Chopra S, Stroud D, Watanabe H, Bennett J, Burns C, Wells K, et al. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res. 2010;106:1342-50 pubmed publisher
    ..These findings identify a novel and possibly nonelectrogenic role for cardiac sodium channels in heart development. ..
  8. Wright M, Mo W, Nicolson T, Ribera A. In vivo evidence for transdifferentiation of peripheral neurons. Development. 2010;137:3047-56 pubmed publisher
    ..However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa. Sodium channel knock-down promotes migration of differentiated sensory neurons away from the ganglia...
  9. Tsai C, Tseng J, Lin S, Chang C, Wu J, Horng J, et al. Primary structure and developmental expression of zebrafish sodium channel Na(v)1.6 during neurogenesis. DNA Cell Biol. 2001;20:249-55 pubmed
    ..6 plays an important role in tactile sensitivity. The abundance of zebrafish Na(v) 1.6 mRNA in the central and peripheral nervous systems increased markedly between 48 and 72 hpf, during the maturation of the nervous system. ..

More Information


  1. Moreno R, Ribera A. Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability. Neural Dev. 2014;9:19 pubmed publisher
  2. YONKERS M, Ribera A. Molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons. Neural Dev. 2009;4:20 pubmed publisher
    ..6a. Our in vivo analyses identify molecules required for T4's rapid regulation of voltage-gated sodium current. ..
  3. Low S, Zhou W, Choong I, Saint Amant L, Sprague S, Hirata H, et al. Na(v)1.6a is required for normal activation of motor circuits normally excited by tactile stimulation. Dev Neurobiol. 2010;70:508-22 pubmed publisher
    ..Genetic mapping identified the gene encoding Na(V)1.6a (scn8aa) as a potential candidate for nav...
  4. Lefebvre K, Tilton S, Bammler T, Beyer R, Srinouanprachan S, Stapleton P, et al. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicol Sci. 2009;107:65-77 pubmed publisher
    ..These data provide a basis for identifying pathways of DA-induced injury as well as biomarkers of asymptomatic and symptomatic DA exposure levels. ..
  5. Chen Y, Huang F, Cheng Y, Wu C, Yang C, Tsay H. Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities. J Biomed Sci. 2008;15:69-78 pubmed
    ..The movement impairments caused by MO1, MO2, and MO3 suggest that the function of Na(v)1.6 sodium channels is essential on the normal early embryonic locomotor activities. ..
  6. Fein A, Meadows L, Chen C, Slat E, Isom L. Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant. BMC Genomics. 2007;8:226 pubmed
    ..Both scn1ba splice forms modulate Na+ currents expressed by zebrafish scn8aa, resulting in shifts in channel gating mode, increased current amplitude, negative shifts in the voltage ..
  7. Lim A, Moussavi Nik S, Ebrahimie E, Lardelli M. Analysis of nicastrin gene phylogeny and expression in zebrafish. Dev Genes Evol. 2015;225:171-8 pubmed publisher
    ..Our observations are consistent with a role for Ncstn protein in Notch signaling within the proliferative ventricular zone of the developing central nervous system. ..
  8. Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
    ..These findings provide the first comparison of zebrafish and rodent DRG neuron electrical properties and thus provide a basis for future studies. ..
  9. Hsieh J, Ulrich B, Issa F, Wan J, Papazian D. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish. Front Neural Circuits. 2014;8:147 pubmed publisher