Gene Symbol: scn5lab
Description: sodium channel, voltage gated, type V-like, alpha b
Alias: scn12ab, wu:fi13c05, zscn5a, sodium channel, voltage gated, type V-like, alpha b, cardiac voltage-gated sodium channel alpha subunit Nav1.5, sodium channel, voltage gated, type VIII, alpha b, sodium channel, voltage gated, type XII, alpha b, zscn7
Novak A, Taylor A, Pineda R, Lasda E, Wright M, Ribera A. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Dev Dyn. 2006;235:1962-73 pubmed
..Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues. ..
Novak A, Jost M, Lu Y, Taylor A, Zakon H, Ribera A. Gene duplications and evolution of vertebrate voltage-gated sodium channels. J Mol Evol. 2006;63:208-21 pubmed publisher
..Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation...
Chopra S, Stroud D, Watanabe H, Bennett J, Burns C, Wells K, et al
. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res. 2010;106:1342-50 pubmed publisher
..Transcripts of the functionally-conserved Scn5a homologs scn5Laa and scn5Lab were detected in the gastrulating zebrafish embryo and subsequently in the embryonic myocardium...
Chopra S, Watanabe H, Zhong T, Roden D. Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates. BMC Evol Biol. 2007;7:113 pubmed
..The evolutionary history of sodium channel beta subunits suggests that these genes may have played a key role in the diversification and specialization of electrical signaling in early vertebrates. ..
Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
..These findings provide the first comparison of zebrafish and rodent DRG neuron electrical properties and thus provide a basis for future studies. ..
Bennett J, Stroud D, Becker J, Roden D. Proliferation of embryonic cardiomyocytes in zebrafish requires the sodium channel scn5Lab. Genesis. 2013;51:562-74 pubmed publisher
..In zebrafish, morpholino knockdown of cardiac sodium channel orthologs scn5Laa and scn5Lab perturbs specification of precardiac mesoderm and inhibits growth of the embryonic heart...
Chetaille P, Preuss C, Burkhard S, CÃ´tÃ© J, Houde C, Castilloux J, et al
. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nat Genet. 2014;46:1245-9 pubmed publisher
..Our findings identify CAID syndrome as a novel generalized dysrhythmia, suggesting a new role for SGOL1 and the cohesin complex in mediating the integrity of human cardiac and gut rhythm. ..