Gene Symbol: scn4aa
Description: sodium channel, voltage-gated, type IV, alpha, a
Alias: Nav1.4a, Nav1.4a, sodium channel protein type 4 subunit alpha A, voltage-gated sodium channel Nav1.4a, voltage-gated sodium channel subunit alpha Nav1.4a, zscn3
Novak A, Taylor A, Pineda R, Lasda E, Wright M, Ribera A. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Dev Dyn. 2006;235:1962-73 pubmed
..Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues. ..
Chopra S, Stroud D, Watanabe H, Bennett J, Burns C, Wells K, et al
. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res. 2010;106:1342-50 pubmed publisher
..These findings identify a novel and possibly nonelectrogenic role for cardiac sodium channels in heart development. ..
Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
..These findings provide the first comparison of zebrafish and rodent DRG neuron electrical properties and thus provide a basis for future studies. ..
Venkatesh B, Lu S, Dandona N, See S, Brenner S, Soong T. Genetic basis of tetrodotoxin resistance in pufferfishes. Curr Biol. 2005;15:2069-72 pubmed
..4b is similar to that in the saxitoxin- and TTX-resistant Na+ channels of softshell clams . Besides helping to deter predators, TTX resistance enables pufferfishes to selectively feed on TTX-bearing organisms. ..
Novak A, Jost M, Lu Y, Taylor A, Zakon H, Ribera A. Gene duplications and evolution of vertebrate voltage-gated sodium channels. J Mol Evol. 2006;63:208-21 pubmed publisher
..Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation...
Patel N, Smith L, Faqeih E, Mohamed J, Gupta V, Alkuraya F. ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6). Hum Mol Genet. 2014;23:6584-93 pubmed publisher
..Our data assign a novel muscular developmental phenotype to ZBTB42 in vertebrates and establish a new LCCS6 type caused by ZBTB42 mutation. ..