Gene Symbol: scn1laa
Description: sodium channel, voltage-gated, type I-like, alpha
Alias: Nav1.1, scn1a, unm_sa1674, zgc:158596, zgc:55600, zscn8, sodium channel, voltage-gated, type I, alpha, sodium channel, voltage-gated, type I-like, alpha, sodium channel, voltage-gated, type I, alpha subunit, voltage-gated sodium channel type I alpha subunit Nav1.1La
Species: zebrafish

Top Publications

  1. Chopra S, Stroud D, Watanabe H, Bennett J, Burns C, Wells K, et al. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res. 2010;106:1342-50 pubmed publisher
    ..These findings identify a novel and possibly nonelectrogenic role for cardiac sodium channels in heart development. ..
  2. Pineda R, Heiser R, Ribera A. Developmental, molecular, and genetic dissection of INa in vivo in embryonic zebrafish sensory neurons. J Neurophysiol. 2005;93:3582-93 pubmed
    ..Finally, analysis of macho mutants indicated that developmental upregulation of INa was absent in RB cells. These results indicate that MOs are a useful tool for the molecular dissection and analysis of ion channel function in vivo. ..
  3. Novak A, Taylor A, Pineda R, Lasda E, Wright M, Ribera A. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Dev Dyn. 2006;235:1962-73 pubmed
    ..Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues. ..
  4. Novak A, Jost M, Lu Y, Taylor A, Zakon H, Ribera A. Gene duplications and evolution of vertebrate voltage-gated sodium channels. J Mol Evol. 2006;63:208-21 pubmed publisher
    ..Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation...
  5. YONKERS M, Ribera A. Molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons. Neural Dev. 2009;4:20 pubmed publisher
    ..6a. Our in vivo analyses identify molecules required for T4's rapid regulation of voltage-gated sodium current. ..
  6. Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
    ..These findings provide the first comparison of zebrafish and rodent DRG neuron electrical properties and thus provide a basis for future studies. ..
  7. Griffin A, Hamling K, Knupp K, Hong S, Lee L, Baraban S. Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. Brain. 2017;140:669-683 pubmed publisher
    ..It is primarily caused by de novo mutations of the SCN1A gene encoding a neuronal voltage-activated sodium channel...
  8. Gau P, Curtright A, Condon L, Raible D, Dhaka A. An ancient neurotrophin receptor code; a single Runx/Cbf? complex determines somatosensory neuron fate specification in zebrafish. PLoS Genet. 2017;13:e1006884 pubmed publisher