Gene Symbol: scn12aa
Description: sodium channel, voltage gated, type XII, alpha a
Alias: sodium channel, voltage gated, type XII, alpha a, scn5Laa, zmp:0000001002, zscn6
Novak A, Taylor A, Pineda R, Lasda E, Wright M, Ribera A. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Dev Dyn. 2006;235:1962-73 pubmed
..Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues. ..
Chopra S, Stroud D, Watanabe H, Bennett J, Burns C, Wells K, et al
. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res. 2010;106:1342-50 pubmed publisher
..Transcripts of the functionally-conserved Scn5a homologs scn5Laa and scn5Lab were detected in the gastrulating zebrafish embryo and subsequently in the embryonic myocardium...
Novak A, Jost M, Lu Y, Taylor A, Zakon H, Ribera A. Gene duplications and evolution of vertebrate voltage-gated sodium channels. J Mol Evol. 2006;63:208-21 pubmed publisher
..Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation...
Chetaille P, Preuss C, Burkhard S, CÃ´tÃ© J, Houde C, Castilloux J, et al
. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nat Genet. 2014;46:1245-9 pubmed publisher
..Our findings identify CAID syndrome as a novel generalized dysrhythmia, suggesting a new role for SGOL1 and the cohesin complex in mediating the integrity of human cardiac and gut rhythm. ..
Won Y, Ono F, Ikeda S. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE. 2012;7:e42602 pubmed publisher
..These findings provide the first comparison of zebrafish and rodent DRG neuron electrical properties and thus provide a basis for future studies. ..
Zhou J, Wang L, Zuo M, Wang X, Ahmed A, Chen Q, et al
. Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm. Sci Rep. 2016;6:21538 pubmed publisher
..5, gata4 and hand2 involved in cardiac morphogenesis. These data for the first time revealed a novel role that MOG1, a nucleocytoplasmic transport protein, plays in cardiac physiology and development. ..