ryr3

Summary

Gene Symbol: ryr3
Description: ryanodine receptor 3
Alias: si:ch211-189g6.1, ryanodine receptor 3, ryanodine receptor 3-like protein
Species: zebrafish

Top Publications

  1. Jurynec M, Xia R, Mackrill J, Gunther D, Crawford T, Flanigan K, et al. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci U S A. 2008;105:12485-90 pubmed publisher
  2. Darbandi S, Franck J. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:443-8 pubmed publisher
    ..Mammals possess three gene copies, RyR1, RyR2, and RyR3 that are expressed in a variety of tissue types...
  3. Hirata H, Watanabe T, Hatakeyama J, Sprague S, Saint Amant L, Nagashima A, et al. Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Development. 2007;134:2771-81 pubmed
    ..These findings suggest that zebrafish relatively relaxed mutants may be useful for understanding the development and physiology of MmD. ..
  4. Wu H, Brennan C, Ashworth R. Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development. BMC Res Notes. 2011;4:541 pubmed publisher
    ..RyRs are differentially expressed in slow (ryr1a), fast (ryr3) and both types (ryr1b) of developing skeletal muscle...
  5. Perni S, Marsden K, Escobar M, Hollingworth S, Baylor S, Franzini Armstrong C. Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle. J Gen Physiol. 2015;145:173-84 pubmed publisher
    ..A second isoform, RyR3, does not sustain EC coupling and differentiation in the absence of RyR1 and is expressed at highly variable levels...
  6. Francescatto L, Rothschild S, Myers A, Tombes R. The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry. Development. 2010;137:2753-62 pubmed publisher
    ..dependent on an intact KV, the PKD2 Ca(2+) channel and gamma1 CaMK-II; however, alphaKAP, beta2 CaMK-II and the RyR3 ryanodine receptor were also necessary for full CaMK-II activation...
  7. Dahlem T, Hoshijima K, Jurynec M, Gunther D, Starker C, Locke A, et al. Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome. PLoS Genet. 2012;8:e1002861 pubmed publisher
    ..In all, it takes about two weeks to create a target-specific TALEN and generate growing embryos that harbor an array of germ line mutations at a pre-specified locus. ..
  8. Holland E, Goldstone J, Pessah I, Whitehead A, Reid N, Karchner S, et al. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquat Toxicol. 2017;192:105-115 pubmed publisher
    ..FKBP1 genes displayed tissue and developmental stage-specific mRNA expression, and the previously uncharacterized RyR3, herein named RyR3b, and all FKBP1 genes were prominent in brain...
  9. Horstick E, Linsley J, Dowling J, Hauser M, McDonald K, Ashley Koch A, et al. Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nat Commun. 2013;4:1952 pubmed publisher
    ..Analysis of NAM stac3 in zebrafish shows that the NAM mutation decreases excitation-contraction coupling. These findings enhance our understanding of both excitation-contraction coupling and the pathology of myopathies. ..

More Information

Publications10

  1. Balci T, Prykhozhij S, Teh E, Da as S, McBride E, Liwski R, et al. A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. Br J Haematol. 2014;167:48-61 pubmed publisher
    ..This study represents the first zebrafish model of a mast cell disease with an aggressive adult phenotype and embryonic markers that could be exploited to screen for novel agents in SM. ..