Gene Symbol: ryr2b
Description: ryanodine receptor 2b (cardiac)
Alias: ryanodine receptor 2, LOW QUALITY PROTEIN: ryanodine receptor 2, ryanodine receptor 2b protein, ryr2
Hirata H, Watanabe T, Hatakeyama J, Sprague S, Saint Amant L, Nagashima A, et al
. Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Development. 2007;134:2771-81 pubmed
..These findings suggest that zebrafish relatively relaxed mutants may be useful for understanding the development and physiology of MmD. ..
Darbandi S, Franck J. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:443-8 pubmed publisher
..Mammals possess three gene copies, RyR1, RyR2, and RyR3 that are expressed in a variety of tissue types...
Wu H, Brennan C, Ashworth R. Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development. BMC Res Notes. 2011;4:541 pubmed publisher
..There are two ryr2 genes (ryr2a and ryr2b) which are expressed exclusively in developing CNS and cardiac tissue, respectively...
Holland E, Goldstone J, Pessah I, Whitehead A, Reid N, Karchner S, et al
. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquat Toxicol. 2017;192:105-115 pubmed publisher
..The outlined sequence differences between mammalian and teleost RyR and FKBP1 together with outlined population differences in SNV frequency may contribute to our understanding of NDL PCB neurotoxicity. ..
Hong Z, Zhang Y, Zuo Z, Zhu R, Gao Y. Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. J Biochem Mol Toxicol. 2015;29:254-60 pubmed publisher
..We found that DA exposure not only disrupted normal cardiac development but also altered the expression of some cardiac development correlated genes and calcium ion channels, such as Anf, Bnp, Atp2a2a, Atp2a2b, Ncx1h, Ryr2b, and Tbx5.
Orr N, Arnaout R, Gula L, Spears D, Leong Sit P, Li Q, et al
. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016;7:11303 pubmed publisher
..These findings describe the cause of a rare subtype of AF due to a primary, atrial-specific sarcomeric defect. ..
Dragojević J, Mihaljević I, Popovic M, Zaja R, Smital T. In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicol In Vitro. 2018;46:246-256 pubmed publisher
..24, and 20.41?M) with Oat2d. This study provides the first comprehensive data set on Oat2 in zebrafish and offers an important basis for more detailed molecular and (eco)toxicological characterizations of these transporters. ..
Palpant N, Hofsteen P, Pabon L, Reinecke H, Murry C. Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes. PLoS ONE. 2015;10:e0126259 pubmed publisher
..Tobacco cigarettes are more toxic than E-cigarettes and exhibit a broader spectrum of cardiac developmental defects. ..