Gene Symbol: ryr2a
Description: ryanodine receptor 2a (cardiac)
Alias: ryr2, ryanodine receptor 2, ryanodine receptor 2a (cardiac), ryanodine receptor 2 (cardiac), zmp:0000001097
Hirata H, Watanabe T, Hatakeyama J, Sprague S, Saint Amant L, Nagashima A, et al
. Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Development. 2007;134:2771-81 pubmed
..These findings suggest that zebrafish relatively relaxed mutants may be useful for understanding the development and physiology of MmD. ..
Darbandi S, Franck J. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:443-8 pubmed publisher
..Mammals possess three gene copies, RyR1, RyR2, and RyR3 that are expressed in a variety of tissue types...
Wu M, Zuo Z, Li B, Huang L, Chen M, Wang C. Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos. Ecotoxicology. 2013;22:1200-7 pubmed publisher
..5 are two factors regulating ventricle conduction. The mRNA expression of RyR2 and Atp2a2b (SERCA2a) was up-regulated in the exposure group, which may be one of reasons to affect the normal ..
Wilson K, Baily J, Tucker C, Matrone G, Vass S, Moran C, et al
. Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Mol Cell Endocrinol. 2015;414:120-31 pubmed publisher
..07Â Î¼g/mg vs controls 0.63Â Â±Â 0.06Â Î¼g/mg, pÂ =Â 0.0007), had increased vmhc and gr mRNA levels. Perturbations in GR activity during embryonic development results in short and long-term alterations in the heart. ..
Holland E, Goldstone J, Pessah I, Whitehead A, Reid N, Karchner S, et al
. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquat Toxicol. 2017;192:105-115 pubmed publisher
..The outlined sequence differences between mammalian and teleost RyR and FKBP1 together with outlined population differences in SNV frequency may contribute to our understanding of NDL PCB neurotoxicity. ..
Wu H, Brennan C, Ashworth R. Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development. BMC Res Notes. 2011;4:541 pubmed publisher
..There are two ryr2 genes (ryr2a and ryr2b) which are expressed exclusively in developing CNS and cardiac tissue, respectively...