Gene Symbol: ryr1b
Description: ryanodine receptor 1b (skeletal)
Alias: im:7137738, si:dkey-250i19.1, ryanodine receptor 1, relatively relaxed, ryanodine receptor 1b (fast muscle)
Species: zebrafish

Top Publications

  1. Darbandi S, Franck J. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:443-8 pubmed publisher
    ..Teleost fish express RyR1a and RyR1b genes that are expressed in slow twitch skeletal muscle and fast twitch skeletal muscles respectively...
  2. Naganawa Y, Hirata H. Developmental transition of touch response from slow muscle-mediated coilings to fast muscle-mediated burst swimming in zebrafish. Dev Biol. 2011;355:194-204 pubmed publisher
    ..This is the first direct demonstration that slow and fast muscles have distinct physiologically relevant contribution in early motor development at different stages. ..
  3. Hirata H, Watanabe T, Hatakeyama J, Sprague S, Saint Amant L, Nagashima A, et al. Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Development. 2007;134:2771-81 pubmed
    Wild-type zebrafish embryos swim away in response to tactile stimulation. By contrast, relatively relaxed mutants swim slowly due to weak contractions of trunk muscles...
  4. Wu H, Brennan C, Ashworth R. Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development. BMC Res Notes. 2011;4:541 pubmed publisher
    ..RyRs are differentially expressed in slow (ryr1a), fast (ryr3) and both types (ryr1b) of developing skeletal muscle...
  5. Dahlem T, Hoshijima K, Jurynec M, Gunther D, Starker C, Locke A, et al. Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome. PLoS Genet. 2012;8:e1002861 pubmed publisher
    ..In all, it takes about two weeks to create a target-specific TALEN and generate growing embryos that harbor an array of germ line mutations at a pre-specified locus. ..
  6. Seebacher F, Walter I. Differences in locomotor performance between individuals: importance of parvalbumin, calcium handling and metabolism. J Exp Biol. 2012;215:663-70 pubmed publisher
    ..We provide mechanistic explanations of why locomotor performance differs between individuals, which is important for understanding ecological and sporting success, disease and the evolutionary processes underlying selection. ..
  7. Dowling J, Arbogast S, Hur J, Nelson D, McEvoy A, Waugh T, et al. Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy. Brain. 2012;135:1115-27 pubmed publisher
    ..discover novel pathogenic mechanisms, we analysed two complementary models of RYR1-related myopathies, the relatively relaxed zebrafish and cultured myotubes from patients with RYR1-related myopathies...
  8. Horstick E, Linsley J, Dowling J, Hauser M, McDonald K, Ashley Koch A, et al. Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nat Commun. 2013;4:1952 pubmed publisher
    ..Analysis of NAM stac3 in zebrafish shows that the NAM mutation decreases excitation-contraction coupling. These findings enhance our understanding of both excitation-contraction coupling and the pathology of myopathies. ..
  9. Todd P, Ackall F, Hur J, Sharma K, Paulson H, Dowling J. Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1. Dis Model Mech. 2014;7:143-55 pubmed publisher

More Information


  1. Perni S, Marsden K, Escobar M, Hollingworth S, Baylor S, Franzini Armstrong C. Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle. J Gen Physiol. 2015;145:173-84 pubmed publisher
    ..This paper provides important evidence that RyR3 is the main constituent of the PJF and is the main contributor to the SR Ca(2+) flux underlying Ca(2+) sparks detected in fully differentiated frog and fish fibers. ..
  2. Linsley J, Hsu I, Groom L, Yarotskyy V, Lavorato M, Horstick E, et al. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proc Natl Acad Sci U S A. 2017;114:E228-E236 pubmed publisher
    ..dihydropyridine receptors (DHPRs) in transverse tubule membrane and Ca2+ release channel ryanodine receptor 1 (RyR1) in the sarcoplasmic reticulum (SR)...
  3. Holland E, Goldstone J, Pessah I, Whitehead A, Reid N, Karchner S, et al. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquat Toxicol. 2017;192:105-115 pubmed publisher
    ..The outlined sequence differences between mammalian and teleost RyR and FKBP1 together with outlined population differences in SNV frequency may contribute to our understanding of NDL PCB neurotoxicity. ..
  4. Hirata H, Wen H, Kawakami Y, Naganawa Y, Ogino K, Yamada K, et al. Connexin 39.9 protein is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish. J Biol Chem. 2012;287:1080-9 pubmed publisher
    ..9 facilitates the spreading of neuronal inputs, which is irregular during motor development, beyond the muscle cells and that gap junctions play an essential role in the efficient recruitment of slow muscle fibers. ..
  5. Paavola J, Schliffke S, Rossetti S, Kuo I, Yuan S, Sun Z, et al. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J Mol Cell Cardiol. 2013;58:199-208 pubmed publisher
    ..In human subjects we found an association between ADPKD and IDCM and suggest that PKD mutations contribute to the development of heart failure. ..
  6. Little A, Seebacher F. Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio). J Exp Biol. 2013;216:3514-21 pubmed publisher
    ..We suggest that the role of TH in modulating SERCA1 expression during cold exposure may have predisposed it to regulate endothermic thermogenesis. ..
  7. Nair N, Gerger C, Hatef A, Weber L, Unniappan S. Ultrasonography reveals in vivo dose-dependent inhibition of end systolic and diastolic volumes, heart rate and cardiac output by nesfatin-1 in zebrafish. Gen Comp Endocrinol. 2016;234:142-50 pubmed publisher
    ..encoding the calcium-handling pump, SERCA2a, while it had no effects on the expression of calcium handling protein RyR1b encoding mRNA...