Gene Symbol: rxrba
Description: retinoid x receptor, beta a
Alias: NR2B2-A, RXR, RXRA, etID309733.19, rxrb, rxre, wu:fb93c09, retinoic acid receptor RXR-beta-A, fb93c09, nuclear receptor subfamily 2 group B member 2-A, retinoid X receptor beta-A, retinoid receptor-epsilon, retinoid x receptor, epsilon
Species: zebrafish

Top Publications

  1. Krasowski M, Yasuda K, Hagey L, Schuetz E. Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. Mol Endocrinol. 2005;19:1720-39 pubmed
    ..PXR specificity for bile salts has thus paralleled the increasing complexity of the bile salt synthetic pathway during vertebrate evolution, an unusual example of ligand-receptor coevolution in the nuclear hormone receptor superfamily. ..
  2. Kawakami Y, Raya A, Raya R, Rodriguez Esteban C, Izpisua Belmonte J. Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 2005;435:165-71 pubmed
  3. Lin S, Chiang M, Shih H, Chiang K, Cheng Y. Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Dev Genes Evol. 2017;227:219-230 pubmed publisher
    ..Our results suggest that foxo4, foxo6a, and foxo6b play important roles in the developing brain and retina and that the transcriptional levels of these genes are regulated by PI3-kinase signaling. ..
  4. Jones B, Ohno C, Allenby G, Boffa M, Levin A, Grippo J, et al. New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid. Mol Cell Biol. 1995;15:5226-34 pubmed
    ..Two additional RXR subtypes (delta and epsilon) isolated from zebra fish cDNA libraries are described here; although both subtypes ..
  5. Gauchat D, Escriva H, Miljkovic Licina M, Chera S, Langlois M, Begue A, et al. The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates. Dev Biol. 2004;275:104-23 pubmed
    ..bound onto the evolutionarily conserved DR1 and DR5 response elements, and repressed transactivation induced by RAR:RXR nuclear receptors in a dose-dependent manner when expressed in mammalian cells...
  6. Krasowski M, Yasuda K, Hagey L, Schuetz E. Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept. 2005;3:2 pubmed
    ..NR genes generally show strong sequence conservation and little evidence for positive selection. The main exceptions are PXR and CAR, genes that may have adapted to cross-species differences in toxic compound exposure. ..
  7. Alsop D, Matsumoto J, Brown S, Van der Kraak G. Retinoid requirements in the reproduction of zebrafish. Gen Comp Endocrinol. 2008;156:51-62 pubmed
    ..and metabolize the hormone retinoic acid (RA) (raldh2 and cyp26a, respectively), and RA receptors (raraa, rarga, rxrba, rxrbb, rxrga but not rxrab). Three new isoforms of rxrba were also observed in a variety of tissues...
  8. Kikuchi K, Holdway J, Major R, Blum N, Dahn R, Begemann G, et al. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev Cell. 2011;20:397-404 pubmed publisher
  9. Li J, Hu P, Li K, Zhao Q. Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter. Anat Rec (Hoboken). 2012;295:268-77 pubmed publisher
    ..Taken together, our results demonstrate that zebrafish cyp26a1 promoter contains a novel RARE that plays crucial roles in regulating cyp26a1 expression during early development of zebrafish. ..

More Information


  1. Oliveira E, Casado M, Raldua D, Soares A, Barata C, Pina B. Retinoic acid receptors' expression and function during zebrafish early development. J Steroid Biochem Mol Biol. 2013;138:143-51 pubmed publisher
    ..its binding to two types of nuclear receptors, the retinoic acid receptor (RAR), and the retinoid-X receptor (RXR), which preferentially binds to the 9-cis isomer...
  2. Escriva H, Safi R, Hanni C, Langlois M, Saumitou Laprade P, Stehelin D, et al. Ligand binding was acquired during evolution of nuclear receptors. Proc Natl Acad Sci U S A. 1997;94:6803-8 pubmed
    ..Strikingly, our results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution. ..
  3. Liu R, Denovan Wright E, Wright J. Structure, linkage mapping and expression of the heart-type fatty acid-binding protein gene (fabp3 ) from zebrafish (Danio rerio). Eur J Biochem. 2003;270:3223-34 pubmed
    ..Inspection of the 5' upstream sequence of the zebrafish fabp3 gene revealed a number of cis elements that may be involved in the expression of the zebrafish fabp3 gene in oocytes and liver. ..