Gene Symbol: rxraa
Description: retinoid X receptor, alpha a
Alias: RXRalpha-B, retinoic acid receptor RXR-alpha-A, NR2B1-B, nuclear receptor subfamily 2 group B member 1-A, retinoid X receptor alpha-A
Kikuchi K, Holdway J, Major R, Blum N, Dahn R, Begemann G, et al
. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev Cell. 2011;20:397-404 pubmed publisher
Ding Y, Liu W, Deng Y, Jomok B, Yang J, Huang W, et al
. Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Circ Res. 2013;112:606-17 pubmed publisher
..The generation of a zebrafish insertional cardiac mutant collection shall facilitate the annotation of a vertebrate cardiac genome, as well as enable heart-based adult screens. ..
Oliveira E, Casado M, Raldua D, Soares A, Barata C, Pina B. Retinoic acid receptors' expression and function during zebrafish early development. J Steroid Biochem Mol Biol. 2013;138:143-51 pubmed publisher
..We conclude that zebrafish embryos are particularly sensitive to potential disruptors of the RAR/RXR regulatory system. ..
Potok M, Nix D, Parnell T, Cairns B. Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell. 2013;153:759-72 pubmed publisher
..Thus, zebrafish achieve a totipotent chromatin state at ZGA through paternal genome competency and maternal genome DNAme reprogramming. ..
Zeng J, Yan J, Wang T, Mosbrook Davis D, Dolan K, Christensen R, et al
. Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Nucleic Acids Res. 2008;36:e8 pubmed
..Our yeast screening strategy, combined with bioinformatics approaches, will allow both detailed and high-throughput characterization of transcription factors, scalable to the analysis of all putative DNA-binding proteins. ..
Li J, Hu P, Li K, Zhao Q. Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter. Anat Rec (Hoboken). 2012;295:268-77 pubmed publisher
..Taken together, our results demonstrate that zebrafish cyp26a1 promoter contains a novel RARE that plays crucial roles in regulating cyp26a1 expression during early development of zebrafish. ..
Lyssimachou A, Santos J, AndrÃ© A, Soares J, Lima D, GuimarÃ£es L, et al
. The Mammalian "Obesogen" Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish. PLoS ONE. 2015;10:e0143911 pubmed publisher
Cunha V, Rodrigues P, Santos M, Moradas Ferreira P, Ferreira M. Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquat Toxicol. 2016;178:182-9 pubmed publisher
..e., abcb4, abcc1, abcc2, abcg2, cyp1a, cyp3a65, gst, sod, cat, ahr, pxr, ppar?, ppar?, ppar?, rxraa, rxrab, rxrbb, rxrga, rxrgb, raraa, rarab, rarga evaluated...
Ding Y, Long P, Bos J, Shih Y, Ma X, Sundsbak R, et al
. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight. 2016;1: pubmed
..Together, our findings establish a mutagenesis screening strategy that is scalable for systematic identification of genetic modifiers of CM, feasible to suggest therapeutic targets, and expandable to other major human diseases. ..