Gene Symbol: rx2
Description: retinal homeobox gene 2
Alias: retinal homeobox protein Rx2
Species: zebrafish
Products:     rx2

Top Publications

  1. Loosli F, Staub W, Finger Baier K, Ober E, Verkade H, Wittbrodt J, et al. Loss of eyes in zebrafish caused by mutation of chokh/rx3. EMBO Rep. 2003;4:894-9 pubmed
    ..Thus, these mutations in orthologous genes allow us to study the evolution of vertebrate eye development at the molecular level. ..
  2. Rojas Muñoz A, Dahm R, NUSSLEIN VOLHARD C. chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis. Dev Biol. 2005;288:348-62 pubmed
    ..Though rx2 is also absent in chk, neither rx2 nor rx1 is required for RPE development...
  3. Stigloher C, Ninkovic J, Laplante M, Geling A, Tannhäuser B, Topp S, et al. Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3. Development. 2006;133:2925-35 pubmed
    ..These results suggest that the process segregating the telencephalic and eye fields is isolated from diencephalic patterning, and is mediated by Rx3. ..
  4. Nelson S, Frey R, Wardwell S, Stenkamp D. The developmental sequence of gene expression within the rod photoreceptor lineage in embryonic zebrafish. Dev Dyn. 2008;237:2903-17 pubmed publisher
  5. Chuang J, Mathers P, Raymond P. Expression of three Rx homeobox genes in embryonic and adult zebrafish. Mech Dev. 1999;84:195-8 pubmed
    ..This is the first transcription factor described that distinguishes between cone and rod photoreceptors. ..
  6. Kennedy B, Stearns G, Smyth V, Ramamurthy V, van Eeden F, Ankoudinova I, et al. Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Dev Biol. 2004;270:336-49 pubmed
    ..We find that expression of mab21l2, mab21l1 and rx2 are specifically absent in the eye field of chk embryos...
  7. Nelson S, Park L, Stenkamp D. Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish. Dev Biol. 2009;328:24-39 pubmed publisher
    ..a temporally-selective gene knockdown approach to identify endogenous functions for the zebrafish rx genes, rx1 and rx2. Depletion of rx1 over the period of eye organogenesis resulted in severely reduced proliferation of retinal ..
  8. Pezeron G, Lambert G, Dickmeis T, Strahle U, Rosa F, Mourrain P. Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. PLoS ONE. 2008;3:e1434 pubmed publisher
    ..This data suggests a new branch of Oep signaling that has implications for germ layer development, as well as for studies of Oep/Frl1/Cripto1 dysfunction, such as that found in tumors. ..
  9. Zou S, Kamei H, Modi Z, Duan C. Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development. PLoS ONE. 2009;4:e7026 pubmed publisher
    ..These results not only provide new insights into the functional conservation and divergence of the multiple igf genes but also reveal a novel role of IGF signaling in midline formation and notochord development in a vertebrate model...

More Information


  1. Zilinski C, Brownell I, Hashimoto R, Medina Martinez O, Swindell E, Jamrich M. Expression of FoxE4 and Rx visualizes the timing and dynamics of critical processes taking place during initial stages of vertebrate eye development. Dev Neurosci. 2004;26:294-307 pubmed
    ..In this paper we present a model of eye development based on the expression pattern of these two genes. ..
  2. Xu T, Zhao J, Yin D, Zhao Q, Dong B. High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 2015;16:23 pubmed publisher
    ..Body curvature arose from enhanced bone resorption because of the intensive up-regulation of related genes. We also proposed the larval retina as a novel potential target tissue for BDE47 exposure. ..
  3. McCollum C, Amin S, Pauerstein P, Lane M. A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3. Dev Biol. 2007;309:373-85 pubmed
    ..We propose that lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS. ..
  4. Tang X, Gao J, Jia X, Zhao W, Zhang Y, Pan W, et al. Bipotent progenitors as embryonic origin of retinal stem cells. J Cell Biol. 2017;216:1833-1847 pubmed publisher
  5. French C, Erickson T, Callander D, Berry K, Koss R, Hagey D, et al. Pbx homeodomain proteins pattern both the zebrafish retina and tectum. BMC Dev Biol. 2007;7:85 pubmed
    ..These data define a novel role for Pbx in patterning the vertebrate retina and tectum in a manner required for proper retinal ganglion cell axon outgrowth. ..
  6. Asaoka Y, Hata S, Namae M, Furutani Seiki M, Nishina H. The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE. 2014;9:e97365 pubmed publisher
    ..Our results suggest that Yap suppresses the differentiation of photoreceptor cells from retinal progenitor cells by repressing Rx1-mediated transactivation of photoreceptor cell genes during zebrafish retinogenesis. ..
  7. Di Donato V, De Santis F, Auer T, Testa N, Sánchez Iranzo H, Mercader N, et al. 2C-Cas9: a versatile tool for clonal analysis of gene function. Genome Res. 2016;26:681-92 pubmed publisher
    ..Our technique has the potential to be applied to diverse model organisms, enabling tissue-specific loss-of-function and phenotypic characterization of live and fixed tissues. ..
  8. Gongal P, Waskiewicz A. Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism. Hum Mol Genet. 2008;17:525-38 pubmed
    ..The consequences of abnormal RA levels for forebrain patterning are profound, and imply that in human patients with TGIF deficiencies, increased forebrain RA levels contribute to the development of HPE. ..
  9. Cavodeassi F, Carreira Barbosa F, Young R, Concha M, Allende M, Houart C, et al. Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron. 2005;47:43-56 pubmed
  10. Stenkamp D, Frey R, Mallory D, Shupe E. Embryonic retinal gene expression in sonic-you mutant zebrafish. Dev Dyn. 2002;225:344-50 pubmed
    ..We also find that Hh signaling is important for retinal cell proliferation and retinal cell survival; together, these functions provide an explanation for progressive microphthalmia in the syu-/- mutant. ..
  11. Kamei H, Ding Y, Kajimura S, Wells M, CHIANG P, Duan C. Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Development. 2011;138:777-86 pubmed publisher
    ..These results suggest that the evolutionarily conserved IGF signaling pathway coordinates growth and temporal development in zebrafish embryos in response to oxygen availability. ..
  12. Gonzalez Nunez V, Nocco V, Budd A. Characterization of drCol 15a1b: a novel component of the stem cell niche in the zebrafish retina. Stem Cells. 2010;28:1399-411 pubmed publisher
  13. Yin J, Morrissey M, Shine L, Kennedy C, Higgins D, Kennedy B. Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis. BMC Genomics. 2014;15:825 pubmed publisher
  14. Perkins B, Nicholas C, Baye L, Link B, Dowling J. dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina. Dev Dyn. 2005;233:680-94 pubmed
    ..Taken together, our studies suggest a role for the dazed gene in rod and Muller cell development and overall retinal cell survival and maintenance. ..