rps11

Summary

Gene Symbol: rps11
Description: ribosomal protein S11
Alias: wu:fa91c09, wu:fb34b11, zgc:56293, 40S ribosomal protein S11
Species: zebrafish

Top Publications

  1. Roca F, Mulero I, López Muñoz A, Sepulcre M, Renshaw S, Meseguer J, et al. Evolution of the inflammatory response in vertebrates: fish TNF-alpha is a powerful activator of endothelial cells but hardly activates phagocytes. J Immunol. 2008;181:5071-81 pubmed
  2. de Oliveira S, Reyes Aldasoro C, Candel S, Renshaw S, Mulero V, Calado A. Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response. J Immunol. 2013;190:4349-59 pubmed publisher
    ..Moreover, we report that Cxcl8-l2 signaled through Cxcr2 for inducing neutrophil recruitment. Our study, therefore, confirms the zebrafish as an excellent in vivo model to shed light on the roles of CXCL8 in neutrophil biology. ..
  3. MacInnes A, Amsterdam A, Whittaker C, Hopkins N, Lees J. Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proc Natl Acad Sci U S A. 2008;105:10408-13 pubmed publisher
    ..Our results show that the appropriate amount of numerous ribosomal proteins is required for p53 protein production in vivo and that disruption of this regulation most likely contributes to tumorigenesis. ..
  4. Espín R, Roca F, Candel S, Sepulcre M, González Rosa J, Alcaraz Pérez F, et al. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2013;6:383-96 pubmed publisher
    ..We have identified an evolutionarily conserved apoptotic pathway involved in vascular homeostasis that provides new therapeutic targets for the control of inflammation- and tumor-driven angiogenesis. ..
  5. Meng F, Braasch I, Phillips J, Lin X, Titus T, Zhang C, et al. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol. 2013;30:1527-43 pubmed publisher
    ..These results show that the independent evolution of retinal degeneration in cavefish can occur by different developmental genetic mechanisms. ..
  6. Candel S, de Oliveira S, López Muñoz A, García Moreno D, Espin Palazon R, Tyrkalska S, et al. Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biol. 2014;12:e1001855 pubmed publisher
    ..These results reveal a crucial role for TNF?/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress and could establish new therapeutic targets for skin inflammatory disorders. ..
  7. Akerberg A, Henner A, Stewart S, Stankunas K. Histone demethylases Kdm6ba and Kdm6bb redundantly promote cardiomyocyte proliferation during zebrafish heart ventricle maturation. Dev Biol. 2017;426:84-96 pubmed publisher
    ..Our results indicate a restricted and likely locus-specific role for Kdm6b demethylases during heart ventricle maturation rather than initial cardiogenesis. ..
  8. Rosowski E, Deng Q, Keller N, Huttenlocher A. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol. 2016;197:4780-4790 pubmed
  9. Tyrkalska S, Candel S, Angosto D, Gómez Abellán V, Martín Sánchez F, García Moreno D, et al. Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins. Nat Commun. 2016;7:12077 pubmed publisher
    ..Our results point to GBPs as key inflammasome adaptors required for prostaglandin biosynthesis and bacterial clearance by neutrophils and suggest that transient activation of the inflammasome may be used to treat bacterial infections. ..

More Information

Publications18

  1. Espin Palazon R, Martínez López A, Roca F, López Muñoz A, Tyrkalska S, Candel S, et al. TNF? Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS Pathog. 2016;12:e1005699 pubmed publisher
    ..This mechanism of action provides new therapeutic targets for the treatment of SVCV-infected fish, and advances our understanding of the previously enigmatic deleterious role of TNF? in certain viral infections. ..
  2. Candel S, Sepulcre M, Espín Palazón R, Tyrkalska S, de Oliveira S, Meseguer J, et al. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Dev Comp Immunol. 2015;50:155-65 pubmed publisher
    ..These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity. ..
  3. Sawamiphak S, Kontarakis Z, Stainier D. Interferon gamma signaling positively regulates hematopoietic stem cell emergence. Dev Cell. 2014;31:640-53 pubmed publisher
    ..Together, our findings uncover a developmental role for an inflammatory cytokine and place its action downstream of Notch signaling and blood flow to control Stat3 activation and HSC emergence. ..
  4. van der Meulen T, Schipper H, Van Leeuwen J, Kranenbarg S. Effects of decreased muscle activity on developing axial musculature in nicb107 mutant zebrafish (Danio rerio). J Exp Biol. 2005;208:3675-87 pubmed
    ..In addition, skin stiffness is affected. In conclusion, the lack of muscle fibre activity did not prevent the basal muscle components developing but influenced further organisation and differentiation of these components. ..
  5. Galindo Villegas J, García Moreno D, de Oliveira S, Meseguer J, Mulero V. Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci U S A. 2012;109:E2605-14 pubmed
  6. Alcaraz Pérez F, García Castillo J, García Moreno D, López Muñoz A, Anchelin M, Angosto D, et al. A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun. 2014;5:3228 pubmed publisher
    ..The alteration in spi1 and gata1 levels occurs through stimulation of gcsf and mcsf. Our model of TR deficiency in the zebrafish illuminates the non-canonical roles of TR, and could establish therapeutic targets for DC. ..
  7. van der Meulen T, Schipper H, van den Boogaart J, Huising M, Kranenbarg S, Van Leeuwen J. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2006;291:R1040-8 pubmed
    ..In contrast, the heart muscle shifts to a faster phenotype but does not become more aerobic. This suggests that endurance training differentially affects heart and axial muscle. ..
  8. de Oliveira S, Boudinot P, Calado Ã, Mulero V. Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications. J Immunol. 2015;194:1523-33 pubmed publisher
  9. Svensson J, Mustafa A, Fick J, Schmitz M, Brunström B. Developmental exposure to progestins causes male bias and precocious puberty in zebrafish (Danio rerio). Aquat Toxicol. 2016;177:316-23 pubmed publisher
    ..Our results show that progestins can affect sexual development in fish and that the androgenic progestin levonorgestrel induces a male phenotype at concentrations similar to those detected in aquatic environments. ..