rpl13

Summary

Gene Symbol: rpl13
Description: ribosomal protein L13
Alias: zgc:92272, 60S ribosomal protein L13
Species: zebrafish
Products:     rpl13

Top Publications

  1. Christen V, Faltermann S, Brun N, Kunz P, Fent K. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos. Sci Total Environ. 2017;586:1204-1218 pubmed publisher
    ..Barquat and BAC let to induction of ER stress and inflammation in vitro, and BAC and glutaraldehyde at non-toxic concentrations in vivo, while benzalkonium chloride induced expression of tnf-? only. ..
  2. Bower N, Vogrin A, Le Guen L, Chen H, Stacker S, Achen M, et al. Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development. Development. 2017;144:507-518 pubmed publisher
    ..These data demonstrate that, rather than being dispensable during development, Vegfd plays context-specific indispensable and also compensatory roles during both blood vessel angiogenesis and lymphangiogenesis. ..
  3. Oggier D, Lenard A, Kury M, Hoeger B, Affolter M, Fent K. Effects of the protein kinase inhibitor PKC412 on gene expression and link to physiological effects in zebrafish Danio rerio eleuthero-embryos. Toxicol Sci. 2011;119:104-15 pubmed publisher
    ..This study leads to the conclusion that PKC412-induced alterations of gene transcripts are partly paralleled by physiological effects at high, but not at low PKC412 concentrations expected to be of environmental relevance. ..
  4. Zucchi S, Oggier D, Fent K. Global gene expression profile induced by the UV-filter 2-ethyl-hexyl-4-trimethoxycinnamate (EHMC) in zebrafish (Danio rerio). Environ Pollut. 2011;159:3086-96 pubmed publisher
    ..The analysis showed tissue-specific gene profiles and revealed that EHMC slightly affects the transcription of genes involved in hormonal pathways including vtg1, esr1, esr2b, ar, cyp19b and hsd17?3. ..
  5. Wincent E, Kubota A, Timme Laragy A, Jönsson M, Hahn M, Stegeman J. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016;110-111:117-29 pubmed publisher
  6. Li Z, Zheng W, Wang Z, Zeng Z, Zhan H, Li C, et al. A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Dis Model Mech. 2013;6:414-23 pubmed publisher
    ..Thus, our zebrafish model demonstrated the conserved role of Myc in promoting hepatocarcinogenesis in all vertebrate species. ..
  7. Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
    ..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
  8. Blüthgen N, Meili N, Chew G, Odermatt A, Fent K. Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). Sci Total Environ. 2014;476-477:207-17 pubmed publisher
    ..Blood levels of 11-ketotestosterone were not altered. The transcriptomics data suggest that OC mainly affects transcription of genes related to developmental processes in the brain and liver as well as metabolic processes in the liver. ..
  9. Blüthgen N, Sumpter J, Odermatt A, Fent K. Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity. Aquat Toxicol. 2013;144-145:96-104 pubmed publisher
    ..Additionally, effects on reproduction and gonad histology described in the associated report (Blüthgen et al., 2013a) can only partly be explained by gene expression data presented here. ..

More Information

Publications20

  1. Rossier N, Chew G, Zhang K, Riva F, Fent K. Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo. Aquat Toxicol. 2016;174:109-22 pubmed publisher
    ..The receptor-based responses did not correspond well to the transcriptional responses in embryos which are much more complex due to the interplay between hormonal pathways, receptor crosstalk, and hormonal feedback loops. ..
  2. Faltermann S, Grundler V, Gademann K, Pernthaler J, Fent K. Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquat Toxicol. 2016;171:77-87 pubmed publisher
    ..This is probably due to action to specific organs such as liver and kidneys that could not be identified by whole-embryo sampling. ..
  3. Amsterdam A, Sadler K, Lai K, Farrington S, Bronson R, Lees J, et al. Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol. 2004;2:E139 pubmed
    ..Our findings suggest that many RP genes may act as haploinsufficient tumor suppressors in fish. Many RP genes might also be cancer genes in humans, where their role in tumorigenesis could easily have escaped detection up to now. ..
  4. Blüthgen N, Zucchi S, Fent K. Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2012;263:184-94 pubmed publisher
    ..Forthcoming studies should show whether this translates to additional physiological effects. ..
  5. Zucchi S, Castiglioni S, Fent K. Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations. Environ Sci Technol. 2012;46:5183-92 pubmed publisher
    ..NET and LNG modulated some transcripts mainly above 2 ng/L. The expressional chances occurring at environmental levels may translate to negative interference with differentiation of brain and gonads, and consequently reproduction. ..
  6. Brugman S, Liu K, Lindenbergh Kortleve D, Samsom J, Furuta G, Renshaw S, et al. Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota. Gastroenterology. 2009;137:1757-67.e1 pubmed publisher
    ..In zebrafish with oxazolone-induced enterocolitis, components of the intestinal microbiota affect the severity and composition of the intestinal infiltrate. ..
  7. Le Guen L, Karpanen T, Schulte D, Harris N, Koltowska K, Roukens G, et al. Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development. 2014;141:1239-49 pubmed publisher
    ..Taken together, these data identify Ccbe1 as a crucial component of the Vegfc/Vegfr3 pathway in the embryo. ..
  8. Christen V, Capelle M, Fent K. Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish. Toxicol Appl Pharmacol. 2013;272:519-28 pubmed publisher
    ..Our data demonstrate for the first time that AgNPs lead to induction of ER stress in zebrafish. The induction of ER stress can have several consequences including the activation of apoptotic and inflammatory pathways...
  9. Wincent E, Jönsson M, Bottai M, Lundstedt S, Dreij K. Aryl hydrocarbon receptor activation and developmental toxicity in zebrafish in response to soil extracts containing unsubstituted and oxygenated PAHs. Environ Sci Technol. 2015;49:3869-77 pubmed publisher
    ..In addition to Ahr activating potency, the profile of cytochrome P4501 inhibitors may also determine the toxic potency of the extracts. ..
  10. Hinaux H, Poulain J, Da Silva C, Noirot C, Jeffery W, Casane D, et al. De novo sequencing of Astyanax mexicanus surface fish and Pachón cavefish transcriptomes reveals enrichment of mutations in cavefish putative eye genes. PLoS ONE. 2013;8:e53553 pubmed publisher
    ..Based on these sequence differences, we provide a list of 11 genes that are potential candidates for having a role in cavefish visual system degeneration...
  11. Oggier D, Weisbrod C, Stoller A, Zenker A, Fent K. Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish Danio rerio. Environ Sci Technol. 2010;44:7685-91 pubmed publisher