Gene Symbol: rpe65c
Description: retinal pigment epithelium-specific protein 65c
Alias: RPE56c, si:ch211-198n5.12, retinal Mueller cells isomerohydrolase, All-trans-retinyl ester 13-cis isomerohydrolase C, All-trans-retinylester 11-cis isomerohydrolase C, Retinal pigment epithelium-specific 65 kDa protein homolog C, meso-zeaxanthin isomerase
Species: zebrafish

Top Publications

  1. Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma J. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011;278:2913-26 pubmed publisher
    ..In the present study, we describe the identification and characterization of a novel isomerohydrolase, RPE65c, from the cone-dominant zebrafish retina...
  2. Takahashi Y, Moiseyev G, Nikolaeva O, Ma J. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012;51:4217-25 pubmed publisher
    ..We recently identified and characterized novel homologues of RPE65, RPE65c, and 13-cis-isomerohydrolase (13cIMH), which are expressed in the zebrafish inner retina and brain, respectively...
  3. Jiang C, Qin B, Liu G, Sun X, Shi H, Ding S, et al. MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway. Oncotarget. 2016;7:52340-52353 pubmed publisher
    ..MiR-184 promotes RPE differentiation via inhibiting the AKT2/mTOR signaling pathway. MiR-184 based supplementary therapeutics and mTOR blocker, like rapamycin, are prospective options for AMD treatment. ..
  4. Chen X, Sheng X, Zhuang W, Sun X, Liu G, Shi X, et al. GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity. Genet Med. 2017;19:945-954 pubmed publisher
    ..The diverse pathogenic modes of GUCA1A mutations may explain the phenotypic diversities.Genet Med advance online publication 26 January 2017. ..