Gene Symbol: rpe65b
Description: retinal pigment epithelium-specific protein 65b
Alias: RPE56b, rpepb, si:ch211-198n5.5, wu:fc74c09, zgc:110538, all-trans-retinyl ester 13-cis isomerohydrolase, 13cIMH, meso-zeaxanthin isomerase, retinal pigment epithelium 65b, retinal pigment epithelium-specific 65 kDa protein homolog B, retinal pigment epithelium-specific protein b
Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma J. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 2011;278:973-87 pubmed publisher
..The present study identified and characterized a novel enzyme in zebrafish brain, 13-cis isomerohydrolase (13cIMH) (EC 188.8.131.52), which exclusively generated 13-cis retinol and can be oxidized to 13cRA...
Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma J. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011;278:2913-26 pubmed publisher
..Identification of an alternative visual cycle will contribute to the understanding of the functional differences of rod and cone photoreceptors. ..
Takahashi Y, Moiseyev G, Nikolaeva O, Ma J. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012;51:4217-25 pubmed publisher
..We recently identified and characterized novel homologues of RPE65, RPE65c, and 13-cis-isomerohydrolase (13cIMH), which are expressed in the zebrafish inner retina and brain, respectively...
Jiang C, Qin B, Liu G, Sun X, Shi H, Ding S, et al
. MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway. Oncotarget. 2016;7:52340-52353 pubmed publisher
..MiR-184 promotes RPE differentiation via inhibiting the AKT2/mTOR signaling pathway. MiR-184 based supplementary therapeutics and mTOR blocker, like rapamycin, are prospective options for AMD treatment. ..
Chen X, Sheng X, Zhuang W, Sun X, Liu G, Shi X, et al
. GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity. Genet Med. 2017;19:945-954 pubmed publisher
..The diverse pathogenic modes of GUCA1A mutations may explain the phenotypic diversities.Genet Med advance online publication 26 January 2017. ..
Schonthaler H, Lampert J, Isken A, Rinner O, Mader A, Gesemann M, et al
. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007;26:1940-9 pubmed
..Thus, our study of zebrafish provides in vivo evidence for the existence of an RPE65-independent pathway for the regeneration of 11-cis-retinal for cone vision. ..