Gene Symbol: rpe65a
Description: retinal pigment epithelium-specific protein 65a
Alias: RPE56a, rpepa, zgc:73213, retinoid isomerohydrolase, all-trans-retinylester 11-cis isomerohydrolase A, meso-zeaxanthin isomerase, retinal pigment epithelium 65a, retinal pigment epithelium-specific 65 kDa protein homolog A, retinal pigment epithelium-specific protein a
Species: zebrafish

Top Publications

  1. Schonthaler H, Lampert J, Isken A, Rinner O, Mader A, Gesemann M, et al. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007;26:1940-9 pubmed
    ..Thus, our study of zebrafish provides in vivo evidence for the existence of an RPE65-independent pathway for the regeneration of 11-cis-retinal for cone vision. ..
  2. Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma J. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 2011;278:973-87 pubmed publisher
    ..These results suggest that 13cIMH may play a key role in the generation of 13cRA, as well as in the modulation of neuronal functions in the brain. ..
  3. Takahashi Y, Moiseyev G, Nikolaeva O, Ma J. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012;51:4217-25 pubmed publisher
    ..These findings will contribute to the elucidation of molecular mechanisms underlying the isomerization reaction catalyzed by RPE65...
  4. Zhang L, Ma P, Collery R, Trowbridge S, Zhang M, Zhong W, et al. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. Mol Vis. 2014;20:56-72 pubmed
    ..In addition, several genes in this group are secreted signaling molecules. Thus, this observation further implicates that the smarca4 RPE might play a role in the retinal dystrophic phenotype in smarca4. ..
  5. Collery R, Volberding P, Bostrom J, Link B, Besharse J. Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages. Invest Ophthalmol Vis Sci. 2016;57:6805-6814 pubmed publisher
    ..These mutant zebrafish will be useful in studying the onset and progression of Mfrp-related nanophthalmia, the cues that initiate the recruitment of macrophages, and the mechanisms of Mfrp function. ..
  6. Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma J. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011;278:2913-26 pubmed publisher
    ..RPE65c shares 78% amino acid sequence identity with RPE-specific zebrafish RPE65a (orthologue of human RPE65) and retains all of the known key residues for the enzymatic activity of RPE65...
  7. Higdon C, Mitra R, Johnson S. Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS ONE. 2013;8:e67801 pubmed publisher
  8. Li Y, Li G, Görling B, Luy B, Du J, Yan J. Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle. PLoS Comput Biol. 2015;11:e1004086 pubmed publisher
    ..Our method is widely applicable to study the impact of circadian transcriptome on metabolism in complex organisms. ..
  9. Houbrechts A, Vergauwen L, Bagci E, Van Houcke J, Heijlen M, Kulemeka B, et al. Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Mol Cell Endocrinol. 2016;424:81-93 pubmed publisher
    ..These data demonstrate the importance of TH-activating and -inactivating Ds for correct zebrafish eye development, and point to D3b as a central player. ..

More Information


  1. Shi Y, Obert E, Rahman B, Rohrer B, Lobo G. The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish. Sci Rep. 2017;7:16207 pubmed publisher