Gene Symbol: rorca
Description: RAR-related orphan receptor C a
Alias: rorc, rorg, RAR-related orphan receptor C a, NR1F3-A, RAR-related orphan receptor G, RORgamma-A, RORgamma1, retinoid-related orphan receptor c
Species: zebrafish

Top Publications

  1. Escriva H, Safi R, Hanni C, Langlois M, Saumitou Laprade P, Stehelin D, et al. Ligand binding was acquired during evolution of nuclear receptors. Proc Natl Acad Sci U S A. 1997;94:6803-8 pubmed
    ..Strikingly, our results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution. ..
  2. Zhang H, Fei C, Wu H, Yang M, Liu Q, Wang Q, et al. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLoS ONE. 2013;8:e73871 pubmed publisher
    ..The transcriptome profiling with microarray revealed the Th17-like immune response to bath-vaccination with the live attenuated V. anguillarum in zebrafish. ..
  3. Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
    ..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
  4. Du L, Yang X, Yang L, Wang X, Zhang A, Zhou H. Molecular evidence for the involvement of ROR? and ROR? in immune response in teleost. Fish Shellfish Immunol. 2012;33:418-26 pubmed publisher
    ..These results not only contribute to elucidate the roles of ROR in fish immunity but also facilitate to further clarify the existence of Th17-like cells in fish. ..
  5. Ojanen M, Turpeinen H, Cordova Z, Hammarén M, Harjula S, Parikka M, et al. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
    ..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
  6. Chi H, Bøgwald J, Dalmo R, Zhang W, Hu Y. Th17 master transcription factors RORα and RORγ regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis. Dev Comp Immunol. 2016;55:169-78 pubmed publisher
    ..These results indicate that RORα and RORγ in teleost regulate the expression of IL-17 members in different manners. ..
  7. Zhao Y, Zhang K, Fent K. Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones. Environ Pollut. 2018;232:422-429 pubmed publisher
    ..Our results suggest that steroid hormones can modulate the circadian molecular network in zebrafish and provide novel insights into their mode of actions and potential environmental risks. ..
  8. Flores M, Hall C, Jury A, Crosier K, Crosier P. The zebrafish retinoid-related orphan receptor (ror) gene family. Gene Expr Patterns. 2007;7:535-43 pubmed
    ..In particular, RORA has been implicated in the regulation of inflammatory cytokine production, and RORC has been shown to be essential in the development of the T lymphocyte repertoire and of secondary lymphoid organs...
  9. Kakizawa T, Nishio S, Triqueneaux G, Bertrand S, Rambaud J, Laudet V. Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha. J Mol Endocrinol. 2007;38:555-68 pubmed
    ..Together, these data suggest that ZfP1 is orthologous to the mammalian P1 promoter, whereas zebrafish ZfP2 has no mammalian ortholog and does not function like ZfP1 to control Rev-erbalpha expression. ..

More Information


  1. Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher