Gene Symbol: rln3b
Description: relaxin 3b
Alias: rflc1, relaxin-3, relaxin family locus C type 1
Park J, Semyonov J, Chang C, Yi W, Warren W, Hsu S. Origin of INSL3-mediated testicular descent in therian mammals. Genome Res. 2008;18:974-85 pubmed publisher
Yegorov S, Good Avila S, Parry L, Wilson B. Relaxin family genes in humans and teleosts. Ann N Y Acad Sci. 2009;1160:42-4 pubmed publisher
..that teleosts harbor orthologs of the human INSL5, H2, H3, and INSL3 genes, so-named RLND/RLNE, RLNC, RLN3a/RLN3b, and RLNF in teleosts, respectively...
Donizetti A, Fiengo M, Minucci S, Aniello F. Duplicated zebrafish relaxin-3 gene shows a different expression pattern from that of the co-orthologue gene. Dev Growth Differ. 2009;51:715-22 pubmed publisher
..Here, we report the expression pattern of the duplicated zebrafish rln3b gene and compare it to the previously analyszd spatial expression pattern of the rln3a gene...
Good Avila S, Yegorov S, Harron S, Bogerd J, Glen P, Ozon J, et al
. Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis. BMC Evol Biol. 2009;9:293 pubmed publisher
..syntenic mapping revealed that fish possess two paralogous copies of human RLN3, which we call rln3a and rln3b, an orthologue of human RLN2, rln, two paralogous copies of human INSL5, insl5a and insl5b, and an orthologue of ..
Fiengo M, Donizetti A, del Gaudio R, Minucci S, Aniello F. Characterization, cDNA cloning and expression pattern of relaxin gene during embryogenesis of Danio rerio. Dev Growth Differ. 2012;54:579-87 pubmed publisher
..In addition, expression in the thyroid and pancreas region suggests a function as a paracrine and endocrine hormone. ..
Good S, Yegorov S, Martijn J, Franck J, Bogerd J. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Int J Evol Biol. 2012;2012:310278 pubmed
..Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals. ..