Gene Symbol: rln3a
Description: relaxin 3a
Alias: RFLC2, rln3, rlx 3a, rlx3a, relaxin 3a, relaxin 3, relaxin family locus C type 2
Wilkinson T, Speed T, Tregear G, Bathgate R. Evolution of the relaxin-like peptide family. BMC Evol Biol. 2005;5:14 pubmed publisher
..We present a phylogeny describing the evolutionary history of the relaxin-like peptide family and show that positive selection has driven the evolution of the most recent members of the family...
Park J, Semyonov J, Chang C, Yi W, Warren W, Hsu S. Origin of INSL3-mediated testicular descent in therian mammals. Genome Res. 2008;18:974-85 pubmed publisher
..hormones, we show that derivation of INSL3-mediated testicular descent involved the duplication of an ancestral RLN3-like gene that encodes an indiscriminate ligand for LGR7 (RXFP1) and LGR8...
Donizetti A, Grossi M, Pariante P, D Aniello E, Izzo G, Minucci S, et al
. Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn. 2008;237:3864-9 pubmed publisher
..This pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish and rat brains, where only scattered cells express the gene in the periaqueductal gray. ..
Fiengo M, Donizetti A, del Gaudio R, Minucci S, Aniello F. Characterization, cDNA cloning and expression pattern of relaxin gene during embryogenesis of Danio rerio. Dev Growth Differ. 2012;54:579-87 pubmed publisher
..Rln B domain shows higher similarity when compared to zebrafish and human RLN3 B domain than human RLN1 and RLN2 B domain...
Donizetti A, Fiengo M, Iazzetti G, del Gaudio R, Di Giaimo R, Pariante P, et al
. Expression analysis of five zebrafish RXFP3 homologues reveals evolutionary conservation of gene expression pattern. J Exp Zool B Mol Dev Evol. 2015;324:22-9 pubmed publisher
Wilson B, Burnett D, Rappaport R, Parry L, Fletcher E. Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish. Comp Biochem Physiol A Mol Integr Physiol. 2009;153:69-74 pubmed publisher
..Relaxin-3 appeared to suppress the release of MIS production. This suggests that relaxin peptides may be involved with estradiol-dependant events in follicular development. ..
Donizetti A, Fiengo M, Minucci S, Aniello F. Duplicated zebrafish relaxin-3 gene shows a different expression pattern from that of the co-orthologue gene. Dev Growth Differ. 2009;51:715-22 pubmed publisher
..of the duplicated zebrafish rln3b gene and compare it to the previously analyszd spatial expression pattern of the rln3a gene...
Good Avila S, Yegorov S, Harron S, Bogerd J, Glen P, Ozon J, et al
. Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis. BMC Evol Biol. 2009;9:293 pubmed publisher
..Comparative syntenic mapping revealed that fish possess two paralogous copies of human RLN3, which we call rln3a and rln3b, an orthologue of human RLN2, rln, two paralogous copies of human INSL5, insl5a and insl5b, and an ..
Good S, Yegorov S, Martijn J, Franck J, Bogerd J. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Int J Evol Biol. 2012;2012:310278 pubmed
..Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals. ..