rfx2

Summary

Gene Symbol: rfx2
Description: regulatory factor X, 2 (influences HLA class II expression)
Alias: cb133, sb:cb133, sb:cb7, wu:fd20b11, zfx2, zgc:91808, DNA-binding protein RFX2, cb7, regulatory factor X 2
Species: zebrafish

Top Publications

  1. Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. BMC Genomics. 2010;11:548 pubmed publisher
  2. Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. BMC Genomics. 2010;11:553 pubmed publisher
    ..This organ forms a conduit for zinc uptake whilst exhibiting conservation of zinc trafficking components...
  3. Neugebauer J, Amack J, Peterson A, Bisgrove B, Yost H. FGF signalling during embryo development regulates cilia length in diverse epithelia. Nature. 2009;458:651-4 pubmed publisher
    ..Abrogation of Fgfr1 signalling downregulates expression of two ciliogenic transcription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polaris), indicating that FGF signalling mediates ..
  4. Verleyen D, Luyten F, Tylzanowski P. Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicle. PLoS ONE. 2014;9:e110484 pubmed publisher
    ..Further, we found that Gpr22 does not act upstream of the two cilia master regulators, Foxj1a and Rfx2. To conclude, our study characterized a novel player in the field of ciliogenesis.
  5. Lu H, Toh M, Narasimhan V, Thamilselvam S, Choksi S, Roy S. A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Dev Biol. 2015;397:225-36 pubmed publisher
    ..Taken together, our findings identify Arl13b as an important effector of ciliary membrane biogenesis and ciliary length regulation, and provide insights into possible mechanisms of dysfunction of the protein in Joubert syndrome. ..
  6. Tavares B, Jacinto R, Sampaio P, Pestana S, Pinto A, Vaz A, et al. Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer. elife. 2017;6: pubmed publisher
    ..This disrupts the normal fluid flow intensity and pattern, with consequent impact on dand5 expression pattern and left-right (L-R) axis establishment. ..
  7. Ma M, Jiang Y. Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct. PLoS Genet. 2007;3:e18 pubmed
    ..While the former is characterized by at least 15 apically localized cilia and expresses centrin2 and rfx2, the latter is characterized by a single primary cilium and sodium pumps...
  8. Liu Y, Pathak N, Kramer Zucker A, Drummond I. Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development. 2007;134:1111-22 pubmed
    ..Jagged 2/Notch signaling modulates the number of multiciliated versus transporting epithelial cells in the pronephros by way of a genetic pathway involving repression of rfx2, a key transcriptional regulator of the ciliogenesis program.
  9. Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, et al. Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development. 2010;137:203-12 pubmed publisher
    ..By contrast, beta cells, whose number is only slightly reduced, were no longer clustered in a compact islet. These data unveil Rfx6 as a novel regulator of islet cell development. ..

More Information

Publications16

  1. Bisgrove B, Makova S, Yost H, Brueckner M. RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Dev Biol. 2012;363:166-78 pubmed publisher
    ..In this study we find that the winged helix transcription factor Rfx2 is expressed in motile cilia in mouse and zebrafish embryos...
  2. Jaffe K, Grimes D, Schottenfeld Roames J, Werner M, Ku T, Kim S, et al. c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Rep. 2016;14:1841-9 pubmed publisher
    ..Kur also makes interactions with other PCP components, including Disheveled. This supports a model wherein Kur plays a dual role in cilia motility and polarization. ..
  3. Yu X, Ng C, Habacher H, Roy S. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat Genet. 2008;40:1445-53 pubmed publisher
    ..Our findings identify a dedicated master regulatory role for Foxj1 in the transcriptional program that controls the production of motile cilia. ..
  4. Hellman N, Liu Y, Merkel E, Austin C, Le Corre S, Beier D, et al. The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A. 2010;107:18499-504 pubmed publisher
  5. Neugebauer J, Cadwallader A, Amack J, Bisgrove B, Yost H. Differential roles for 3-OSTs in the regulation of cilia length and motility. Development. 2013;140:3892-902 pubmed publisher
    ..in the fibroblast growth factor pathway to control cilia length via the ciliogenic transcription factors FoxJ1a and Rfx2. By contrast, a second 3-OST family member, 3-OST-6, does not regulate cilia length, but regulates cilia motility ..
  6. Arrington C, Peterson A, Yost H. Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry. Development. 2013;140:4102-9 pubmed publisher
    ..Through an Fgf2-independent pathway, Sdc2 and Tbx16 also control KV ciliogenesis. Our results uncover a novel Sdc2-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis...
  7. Liu J, Merkle F, Gandhi A, Gagnon J, Woods I, Chiu C, et al. Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development. 2015;142:1113-24 pubmed publisher
    ..Our results elucidate an evolutionarily conserved role for Lhx9 in Hcrt neuron specification that improves our understanding of Hcrt neuron development. ..