Gene Symbol: reln
Description: reelin
Alias: reelin
Species: zebrafish

Top Publications

  1. Li A, Sun Y, Dou C, Chen J, Zhang J. Lysine-specific demethylase 1 expression in zebrafish during the early stages of neuronal development. Neural Regen Res. 2012;7:2719-26 pubmed publisher
    ..led to the loss of cells in the brain and to a dramatic downregulation of neural genes, including gad65, gad75, and reelin, but not hey1. These findings indicate an important role of Lsd1 during nervous system development in zebrafish.
  2. Mione M, Lele Z, Kwong C, Concha M, Clarke J. Expression of pcp4a in subpopulations of CNS neurons in zebrafish. J Comp Neurol. 2006;495:769-87 pubmed
    ..The analysis of pcp4a expression and localization in the zebrafish brain suggests that pcp4a may be a useful marker for sensory and some motor neuronal circuitries and for telencephalic areas processing sensory inputs. ..
  3. Foucher I, Mione M, Simeone A, Acampora D, Bally Cuif L, Houart C. Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development. 2006;133:1891-900 pubmed
    ..This maintenance is enough to allow cerebellar differentiation. ..
  4. Volkmann K, Rieger S, Babaryka A, Köster R. The zebrafish cerebellar rhombic lip is spatially patterned in producing granule cell populations of different functional compartments. Dev Biol. 2008;313:167-80 pubmed
    ..Thus, our findings offer an explanation for how specific functional cerebellar circuitries are laid down by spatio-temporal patterning of cerebellar germinal zones during early brain development. ..
  5. Anichtchik O, Diekmann H, Fleming A, Roach A, Goldsmith P, Rubinsztein D. Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci. 2008;28:8199-207 pubmed publisher
    ..This provides new insights into the biology of PINK1 and a possible therapeutic avenue for further investigation. ..
  6. Larson T, Gordon T, Lau H, Parichy D. Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Dev Biol. 2010;346:296-309 pubmed publisher
    ..This study identifies the puma mutant as a valuable model for studying microtubule-dependent events of myelination, as well as strategies for remyelination in the adult. ..
  7. Imai H, Oomiya Y, Kikkawa S, Shoji W, Hibi M, Terashima T, et al. Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period. Dev Growth Differ. 2012;54:253-63 pubmed publisher
    ..Because the Reelin signal plays important roles in the development of the laminar structures in mammalian brain, investigation of ..
  8. Kaslin J, Ganz J, Geffarth M, Grandel H, Hans S, Brand M. Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. J Neurosci. 2009;29:6142-53 pubmed publisher
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates. ..
  9. Elsen G, Choi L, Prince V, Ho R. The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol. 2009;335:78-92 pubmed publisher
    ..These functions may underlie the correlation between altered MET regulation and autism spectrum disorders. ..

More Information


  1. Peterson S, Zhang J, Weber G, Freeman J. Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations. Environ Health Perspect. 2011;119:615-21 pubmed publisher
    ..Moreover, we identified a number of novel targets for future exploration into their role in the genetic mechanisms underlying Pb-induced neurological alterations. ..
  2. Peterson S, Zhang J, Freeman J. Developmental reelin expression and time point-specific alterations from lead exposure in zebrafish. Neurotoxicol Teratol. 2013;38:53-60 pubmed publisher
    b>Reelin (RELN) is a large glycoprotein that plays critical roles during and after neuronal development...
  3. Tsai M, Lu Y, Liu Y, Lien H, Huang C, Wu J, et al. Modulation of p53 and met expression by Krüppel-like factor 8 regulates zebrafish cerebellar development. Dev Neurobiol. 2015;75:908-26 pubmed publisher
  4. Lin C, Taggart A, Lim K, Cygan K, Ferraris L, Creton R, et al. RNA structure replaces the need for U2AF2 in splicing. Genome Res. 2016;26:12-23 pubmed publisher
    ..While largely lost from land dwelling vertebrates, this class of introns is found in 10% of all zebrafish genes. ..
  5. Volkmann K, Chen Y, Harris M, Wullimann M, Köster R. The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. J Comp Neurol. 2010;518:2794-817 pubmed publisher
  6. Wirbisky S, Weber G, Sepúlveda M, Xiao C, Cannon J, Freeman J. Developmental origins of neurotransmitter and transcriptome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Toxicology. 2015;333:156-67 pubmed publisher
    ..These results provide support of the developmental origins of neurological alterations observed in adult female zebrafish exposed to atrazine during embryogenesis. ..