Gene Symbol: rdh10a
Description: retinol dehydrogenase 10a
Alias: wu:fb92b11, zgc:158459, retinol dehydrogenase 10-A
Lupo G, Gestri G, O Brien M, Denton R, Chandraratna R, Ley S, et al
. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proc Natl Acad Sci U S A. 2011;108:8698-703 pubmed publisher
..Furthermore, the identification of two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. ..
Cardozo M, Sánchez Arrones L, Sandonìs A, Sánchez Camacho C, Gestri G, Wilson S, et al
. Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Nat Commun. 2014;5:4272 pubmed publisher
..This Ptc-independent function protects the retinal primordium from Hh activity, defines the stalk/retina boundary and thus the correct proximo-distal patterning of the eye. ..
Valdivia L, Lamb D, Horner W, Wierzbicki C, Tafessu A, Williams A, et al
. Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish. Development. 2016;143:1087-98 pubmed publisher
..Together, our results support a model in which dorsally expressed gdf6a limits RA pathway activity to control the transition from proliferation to differentiation in the growing eye. ..
Blum N, Begemann G. Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration. Development. 2012;139:107-16 pubmed publisher
D Aniello E, Rydeen A, Anderson J, Mandal A, Waxman J. Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. PLoS Genet. 2013;9:e1003689 pubmed publisher
..Our results support an intriguing novel mechanism by which depletion of RARs elicits a previously unrecognized positive feedback loop that can result in developmental defects due to teratogenic increases in embryonic RA...
Rydeen A, Voisin N, D Aniello E, Ravisankar P, Devignes C, Waxman J. Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling. Dev Biol. 2015;405:47-55 pubmed publisher
..Therefore, our results provide novel insights into the teratogenic mechanisms of RA signaling and the cellular mechanisms by which Cyp26a1 expression can shape a RA gradient. ..
D Aniello E, Ravisankar P, Waxman J. Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS ONE. 2015;10:e0138588 pubmed publisher
..Here, we report that zebrafish Rdh10a deficient embryos have defects consistent with loss of RA signaling, including anteriorization of the nervous ..
Brown J, Snir M, Noushmehr H, Kirby M, Hong S, Elkahloun A, et al
. Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Proc Natl Acad Sci U S A. 2008;105:12337-42 pubmed publisher
..This specific loss of sox17 establishes a new class of endoderm specification defect. ..