Gene Symbol: rack1
Description: receptor for activated C kinase 1
Alias: gnb2l1, wu:fb80d08, wu:fk65d12, guanine nucleotide-binding protein subunit beta-2-like 1, RACK, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, receptor for activated protein kinase C, receptor of activated protein kinase C
Species: zebrafish
Products:     rack1

Top Publications

  1. Takezaki N, Figueroa F, Zaleska Rutczynska Z, Klein J. Molecular phylogeny of early vertebrates: monophyly of the agnathans as revealed by sequences of 35 genes. Mol Biol Evol. 2003;20:287-92 pubmed
    ..Our analyses also give a strong support for the separation of Chondrichthyes (cartilaginous fishes) before the divergence of Osteichthyes (bony fishes) from the other gnathostomes...
  2. Hamilton -, Wright -. Isolation of Complementary DNAs Coding for a Receptor for Activated C Kinase (RACK) from Zebrafish (Danio rerio) and Tilapia (Oreochromis niloticus): Constitutive Developmental and Tissue Expression. Mar Biotechnol (NY). 1999;1:279-285 pubmed
    We have cloned and sequenced complementary DNAs coding for a receptor for activated C kinase (RACK) from two species of teleost fishes, zebrafish (Danio rerio) and tilapia (Oreochromis niloticus)...
  3. Sharma M, Denovan Wright E, Boudreau M, Wright J. A cellular retinoic acid-binding protein from zebrafish (Danio rerio): cDNA sequence, phylogenetic analysis, mRNA expression, and gene linkage mapping. Gene. 2003;311:119-28 pubmed
    ..Based on phylogenetic analysis and the syntenic relationship to the CRABPII gene in human, the zebrafish cDNA clone appears to code for a type II CRABP. ..
  4. Sharma M, Denovan Wright E, Degrave A, Thisse C, Thisse B, Wright J. Sequence, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2004;138:391-8 pubmed
    ..Expression in YSL, liver or pancreas has not been previously reported for fish or mammalian I-FABP genes and may be related to specific physiological differences between fishes and mammals. ..
  5. de Pater E, Ciampricotti M, Priller F, Veerkamp J, Strate I, Smith K, et al. Bmp signaling exerts opposite effects on cardiac differentiation. Circ Res. 2012;110:578-87 pubmed publisher
    ..Bmp signaling exerts opposing effects on myocardial differentiation in the embryo by promoting as well as inhibiting cardiac growth. ..
  6. Liu Q, Basu N, Goetz G, Jiang N, Hutz R, Tonellato P, et al. Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology. 2013;22:740-51 pubmed publisher
    ..Our conclusion is that biomarker analysis for aquatic toxicant assessment using fish needs to be based on tissue-, sex- and species-specific consideration. ..
  7. Liu Q, Spitsbergen J, Cariou R, Huang C, Jiang N, Goetz G, et al. Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish. PLoS ONE. 2014;9:e100910 pubmed publisher
    ..These baseline toxicological effects provide evidence for the potential mechanisms of developmental dysfunctions induced by TCDD and vasa as a biomarker for ovarian developmental disruption. ..
  8. Horstick E, Jordan D, Bergeron S, Tabor K, Serpe M, Feldman B, et al. Increased functional protein expression using nucleotide sequence features enriched in highly expressed genes in zebrafish. Nucleic Acids Res. 2015;43:e48 pubmed publisher
    ..Rational gene design thus significantly boosts expression in zebrafish, and a similar approach will likely elevate expression in other animal models. ..
  9. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase. ..

More Information


  1. Mulligan T, Blaser H, Raz E, Farber S. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cell Signal. 2010;22:221-33 pubmed publisher
  2. Li S, Esterberg R, Lachance V, Ren D, Radde Gallwitz K, Chi F, et al. Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc Natl Acad Sci U S A. 2011;108:2264-9 pubmed publisher
    ..Here, we report the identification of Rack1 as an interacting protein of a vertebrate Vang protein, Vangl2...