Gene Symbol: rab7
Description: RAB7, member RAS oncogene family
Alias: rab-7, zgc:64058, ras-related protein Rab-7a
Species: zebrafish
Products:     rab7

Top Publications

  1. Clark B, Winter M, Cohen A, Link B. Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. Dev Dyn. 2011;240:2452-65 pubmed publisher
    ..transgenic lines ubiquitously express EGFP fusions of Rab5c (early endosomes), Rab11a (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development...
  2. Roostalu U, Strahle U. In vivo imaging of molecular interactions at damaged sarcolemma. Dev Cell. 2012;22:515-29 pubmed publisher
    ..Thus, sarcolemmal repair relies on the ordered assembly of a protein-membrane scaffold. Moreover, we provide several lines of evidence that the membrane for sarcolemmal repair is derived from a specialized plasma membrane compartment. ..
  3. De Felice B, Copia L, Guida M. Gene expression profiling in zebrafish embryos exposed to diclofenac, an environmental toxicant. Mol Biol Rep. 2012;39:2119-28 pubmed publisher
    ..Our results, for the first time, provide an insight into some of the varied and novel molecular networks following zebrafish exposure to diclofenac polluted waters. ..
  4. Sonal -, Sidhaye J, Phatak M, Banerjee S, Mulay A, Deshpande O, et al. Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis. PLoS Genet. 2014;10:e1004614 pubmed publisher
    ..Our analyses unravel the importance of Myosin Vb dependent cell size regulation in epidermal homeostasis and demonstrate that the epidermis has the ability to maintain a dynamic balance between cell size and cell number. ..
  5. Hagemann A, Kurz J, Kauffeld S, Chen Q, Reeves P, Weber S, et al. In vivo analysis of formation and endocytosis of the Wnt/?-catenin signaling complex in zebrafish embryos. J Cell Sci. 2014;127:3970-82 pubmed publisher
    ..We conclude that Ap2?2-mediated endocytosis is important to maintain Wnt/?-catenin signaling in vertebrates. ..
  6. Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, et al. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017;3:17067 pubmed publisher
    ..Inside the cytosol, A. hydrophila avoids detection by suppressing NLRs, facilitating its survival and ensuing pathogenesis. ..
  7. George A, Hayden S, Stanton G, Brockerhoff S. Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors. Bioessays. 2016;38 Suppl 1:S119-35 pubmed publisher
    ..Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. ..
  8. Oltrabella F, Pietka G, Ramirez I, Mironov A, Starborg T, Drummond I, et al. The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule. PLoS Genet. 2015;11:e1005058 pubmed publisher
    ..Moreover, our results reveal PIP5K as a potential therapeutic target for Lowe syndrome and Dent-2 disease. ..
  9. Kressmann S, Campos C, Castanon I, Fürthauer M, González Gaitán M. Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord. Nat Cell Biol. 2015;17:333-9 pubmed publisher

More Information


  1. Rasmussen J, Sack G, Martin S, Sagasti A. Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris. J Neurosci. 2015;35:559-70 pubmed publisher
    ..Together, these results identify vertebrate epidermal cells as broad-specificity phagocytes that likely contribute to neural repair and wound healing. ..
  2. He Y, Liu D, Xi D, Yang L, Tan Y, Liu Q, et al. Isolation, sequence identification and expression profile of three novel genes Rab2A, Rab3A and Rab7A from Black-boned sheep (Ovis aries). Mol Biol (Mosk). 2010;44:20-7 pubmed
    ..And the Black-boned sheep Rab7A gene encodes a protein of 207 amino acids that contains the conserved putative Rab7 domain and has high homology with the Rab7A proteins of six other species--human (99%), dog (99%), Sumatran ..
  3. Ellis K, Bagwell J, Bagnat M. Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. J Cell Biol. 2013;200:667-79 pubmed publisher
    ..Thus, the vertebrate notochord plays important structural roles beyond early development...
  4. Fassier C, Hutt J, Scholpp S, Lumsden A, Giros B, Nothias F, et al. Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nat Neurosci. 2010;13:1380-7 pubmed publisher
  5. Ponomareva O, Holmen I, Sperry A, Eliceiri K, Halloran M. Calsyntenin-1 regulates axon branching and endosomal trafficking during sensory neuron development in vivo. J Neurosci. 2014;34:9235-48 pubmed publisher
    ..Our results suggest a model in which Clstn-1 patterns separate axonal compartments and define their ability to branch by directing trafficking of specific endosomes. ..
  6. George A, Hayden S, Holzhausen L, Ma E, Suzuki S, Brockerhoff S. Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments. PLoS ONE. 2014;9:e84394 pubmed publisher
    ..This last pathway also appears exacerbated by darkness. Taken altogether, these findings show that SynJ1 is required in cones for normal endolysosomal trafficking of synaptic proteins. ..
  7. Ponomareva O, Eliceiri K, Halloran M. Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development. Neural Dev. 2016;11:2 pubmed publisher
    ..Five missense mutations in the gene encoding Rab7 GTPase have been identified as causative in human CMT2b disease...
  8. George A, Hayden S, Stanton G, Brockerhoff S. Arf6 and the 5'phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors. Inside Cell. 2016;1:117-133 pubmed
    ..Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. ..